RIKEN ECL Research Team / RIKEN ECL Research Unit Chrono-Developmental Biology RIKEN ECL Research Team
RIKEN ECL Team Leader: Masayuki Oginuma (Ph.D.)
Research Summary
Organisms possess a remarkable "blueprint of time." Embryonic development, from fertilization to the processes of body formation, follows a precise schedule regulated by a clock mechanism encoded in the genes. However, the specific underlying molecular mechanism remains largely unknown. The turquoise killfish, N. furzeri, which inhabit the ephemeral ponds in Africa, can suspend their embryonic development and enter a state of diapause for extended periods. Our lab aims to clarify the mechanisms of diapause, a highly evolved developmental clock-stopping phenomenon, reveal the complete picture of the "blueprint of time," and apply our findings to other organisms.
Main Research Fields
- Biology
Related Research Fields
- Biological Sciences
- Medicine, Dentistry & Pharmacy
- Developmental biology
Keywords
- Embryonic development
- Diapause
- Clock
- metabolism
- Time
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
*Oginuma M, Nishida M, Ohmura-Adachi T, et al.
"Rapid reverse genetics systems for N. furzeri, a suitable model organism to study vertebrate aging"
Scientific Reports, 12. 11628 (2022) - 2.
*Oginuma M, Harima Y, Tarazona OA, et al.
"Intracellular pH controls Wnt signaling downstream of glycolysis in the vertebrate embryo."
Nature, 584: 98-101 (2020) - 3.
*Zhao W, Oginuma M, Ajima R, et al.
"Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis."
Elife, 15, 33068 (2018) - 4.
*Oginuma M, Moncuquet P, Xiong F, et al.
"Gradient of Glycolytic Activity Coordinates FGF and Wnt Signaling during Elongation of the Body Axis in Amniote Embryos"
Developmental Cell 40, 342-353 (2017) - 5.
*Chal J, Oginuma M, Z Al Tanoury, et al.
"Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy".
Nature Biotechnol 33, 962-969 (2015) - 6.
*Oginuma M, Takahashi Y, S Kitajima, et al.
"The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite."
Development 137,1515-22 (2010) - 7.
*Oginuma M, Niwa Y, Chapman D, Saga Y.:
"Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis."
Development, 135,2555-62 (2008) - 8.
*Oginuma M, Hirata T, Saga Y.:
"Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM- specific Mesp1/Mesp2-null mouse using BAC-based rescue technology."
Mechanisms of Development, 125, 432-40 (2008)
Related Links
Lab Members
Principal investigator
- Masayuki Oginuma
- RIKEN ECL Team Leader
Contact Information
Developmental Biology Buildings (DB Buildings) 7th floor
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047
Email: masayuki.oginuma [at] riken.jp