Research Summary

Selected Publications

• 1. Takeda H, Matsuzawa Y, Takeuchi M, Takahashi M, Nizhida K, Harayama T, Todoroki Y, Shimizu K, Sakamoto N, Oka T, Maekawa M, Chung MH, Kurizaki Y, Kiuchi S, Kvasnička A, Takeda U, Uchino H, Hasegawa M, Miyamoto J, Tanabe K, Takeda S, Mori T, Tanaka T, Yoshino T, Saito K, Okamoto M, Takahashi H, Arita M, Tsugawa H.
  "MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities."
  Nature Communications in press
• 2. Tsugawa H, Ishihara T, Ogasa K, Iwanami S, Hori A, Takahashi M, Yamada Y, Satoh-Takayama N, Ohno H, Minoda A, Arita M."
  "A lipidome landscape of aging in mice.
  Nature Aging 4, 709-726 (2024)
• 3. Kuroha S, Katada Y, Isobe Y, Uchino H, Shishikura K, Nirasawa T, Tsubota K, Negishi K, Kurihara T, Arita M.
  "Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice."
  FASEB Journal 37, e23151 (2023)
• 4. Iino Y, Naganuma T, Arita M.
  "Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1."
  Journal of Lipid Research 64, 100329 (2023)
• 5. Aoki H, Isobe Y, Yoshida M, Kang JX, Maekawa M, Arita M.
  "Enzymatically-epoxidized docosahexaenoic acid, 19,20-EpDPE, suppresses hepatic crown-like structure formation and nonalcoholic steatohepatitis fibrosis through GPR120."
  Biochim Biophys Acta Mol Cell Biol Lipids 1868, 159275 (2023)
• 6. Uchino H, Tsugawa H, Takahashi H, Arita M.
  "Computational mass spectrometry accelerates C=C position-resolved untargeted lipidomics using oxygen attachment dissociation."
  Communications Chemistry 5, 162 (2022)
• 7. Yoshida M, Ishihara T, Isobe Y, Arita M.
  "Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis."
  FASEB Journal 36, e22648 (2022)
• 8. Miyata J, Yokokura Y, Moro K, Arai H, Fukunaga K, Arita M.
  "12/15-Lipoxygenase regulates IL-33-induced eosinophilic airway inflammation in mice."
  Frontiers in Immunology 12, 687192 (2021)
• 9. Yasuda S, Okahashi N, Tsugawa H, Ogata Y, Ikeda K, Suda W, Arai H, Hattori M, Arita M.
  "Elucidation of gut microbiota-associated lipids using LC-MS/MS and 16S rRNA sequence analyses."
  iScience 23, 101841 (2020)
• 10. Tsugawa H, Ikeda K, Takahashi M, Satoh A, Mori Y, Uchino H, Okahashi N, Yamada Y, Tada I, Bonini P, Higashi Y, Okazaki Y, Zhou Z, Zhu Z, Koelmel J, Cajka T, Fiehn O, Saito K, Arita M, Arita M.
  "A lipidome atlas in MS-DIAL 4."
  Nature Biotechnology 38, 1159-1163 (2020)

Recent Research Results

• 

  Jun. 5, 2024
  Cracking the aging code: Insights into lipid changes

• 

  Jun. 19, 2020
  Advancing lipidomics: researchers establish atlas of lipids in living organisms

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