RIKEN Center for Advanced Intelligence Project AI Medical Engineering Team

Team Director: Ryuji Hamamoto (Ph.D.)

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Research Summary

Our team is collaborating with medical institutions, primarily the National Cancer Center, to analyze large-scale medical data using the latest AI technology. Our goal is to elucidate disease mechanisms and apply our findings to the development of new diagnostic methods and drug discovery. We are promoting research with a particular focus on the clinical application (social implementation) of our findings, and to date, we have obtained pharmaceutical approval and certification under the Pharmaceutical and Medical Devices Act for multiple research findings, which have been applied in clinical practice.

Research Subjects:

Elucidation of the molecular mechanism of cancer and other diseases based on large-scale medical data analysis
Development and clinical application of AI-enabled programmable medical devices
Analysis of omics data using AI and its application to drug discovery

Main Research Fields

Medicine, Dentistry & Pharmacy

Related Research Fields

Informatics
Complex Systems
Biological Sciences

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. Asada, K., Kaneko, S., Takasawa, K., Shiraishi, K., Shinkai, N., Shimada, Y., Takahashi, S., Machino, H., Kobayashi, K., Bolatkan, A., Komatsu, M., Yamada, M., Miyake, M., Watanabe, H., Tateishi, A., Mizuno, T., Okubo, Y., Mukai, M., Yoshida, T., Yoshida, Y., Horinouchi, H., Watanabe, S.I., Ohe, Y., Yatabe, Y., Kohno, T., Hamamoto, R.:
"Multi-omics and clustering analyses reveal the mechanisms underlying unmet needs for patients with lung adenocarcinoma and identify potential therapeutic targets"
Molecular Cancer 23, 182 (2024)
2. Kaneko, S., Takasawa, K., Asada, K., Shiraishi, K., Ikawa, N., Machino, H., Shinkai, N., Matsuda, M., Masuda, M., Adachi, S., Takahashi, S., Kobayashi, K., Kouno, N., Bolatkan, A., Komatsu, M., Yamada, M., Miyake, M., Watanabe, H., Tateishi, A., Mizuno, T., Okubo, Y., Mukai, M., Yoshida, T., Yoshida, Y., Horinouchi, H., Watanabe, S.I., Ohe, Y., Yatabe, Y., Saloura, V., Kohno, T., Hamamoto, R.:
"Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations"
Molecular Cancer 23, 126 (2024)
3. Mochizuki, A., Shiraishi, K., Honda, T., Higashiyama, R.I., Sunami, K., Matsuda, M., Shimada, Y., Miyazaki, Y., Yoshida, Y., Watanabe, S.I., Yatabe, Y., Hamamoto, R., Kohno, T.:
"Passive smoking-induced mutagenesis as a promoter of lung carcinogenesis"
Journal of Thoracic Oncology 19, 984-994 (2024)
4. Kobayashi, K., Gu, L., Hataya, R., Mizuno, T., Miyake, M., Watanabe, H., Takahashi, M., Takamizawa, Y., Yoshida, Y., Nakamura, S., Kouno, N., Bolatkan, A., Kurose, Y., Harada, T., Hamamoto, R.:
"Sketch-based semantic retrieval of medical images"
Medical Image Analysis 92, 103060 (2024)
5. Igarashi, T., Mazevet, M., Yasuhara, T., Yano, K., Mochizuki, A., Nishino, M., Yoshida, T., Yoshida, Y., Takamatsu, N., Yoshimi, A., Shiraishi, K., Horinouchi, H., Kohno, T., Hamamoto, R., Adachi, J., Zou, L., Shiotani, B.:
"An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress"
Nature Communications 14, 4991 (2023)
6. Kobayashi, K., Hataya, R., Kurose, Y., Miyake, M., Takahashi, M., Nakagawa, A., Harada, T., Hamamoto, R.:
"Decomposing normal and abnormal features of medical images for content-based image retrieval of glioma imaging"
Medical Image Analysis 74, 102227 (2021)
7. Matsuno, Y., Atsumi, Y., Shimizu, A., Katayama, K., Fujimori, H., Hyodo, M., Minakawa, Y., Nakatsu, Y., Kaneko, S., Hamamoto, R., Shimamura, T., Miyano, S., Tsuzuki, T., Hanaoka, F., Yoshioka, K.I.:
"Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro"
Nature Communications 10, 3925 (2019)
8. *Hamamoto, R., Saloura, V., Nakamura, Y.:
"Critical roles of non-histone protein lysine methylation in human tumorigenesis"
Nature Reviews Cancer 15, 110-124 (2015)
9. *Sone, K., Piao, L., Nakakido, M., Ueda, K., Jenuwein, T., Nakamura, Y., Hamamoto, R.:
"Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair"
Nature Communications 10, 3925 (2019)
10. *Cho, H.S., Shimazu, T., Toyokawa, G., Daigo, Y., Maehara, Y., Hayami, S., Ito, A., Masuda, K., Ikawa, N., Field, H.I., Tsuchiya, E., Ohnuma, S., Ponder, B.A.J., Yoshida M., Nakamura, Y., Hamamoto, R.:
"Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of aurora kinase B"
Nature Communications 3, 1072 (2012)