RIKEN Center for Advanced Intelligence Project Computational Brain Dynamics Team
Team Director: Okito Yamashita (Ph.D.)
Research Summary

Mental disorder is becoming one of the most serious problems in our society. We are developing big data analysis and dynamics modeling methods of human brain imaging data such as fMRI, MEG, EEG and NIRS in order to realize novel imaging-based diagnosis and therapy.
Research Subjects:
- human brain imaging
- brain dynamics model
- mental disorder
Main Research Fields
- Neuroscience & Behavior
Related Research Fields
- Computer Science
- Mathematics
Selected Publications
- 1.
Itahashi, T., Yamashita, A., Takahara, Y., Yahata, N., Aoki, Y. Y., Fujino, J., …, Yamashita O. & Hashimoto, R. I.:
"Generalizable and transportable resting-state neural signatures characterized by functional networks, neurotransmitters, and clinical symptoms in autism."
Molecular Psychiatry, 1-13. (2024) - 2.
Tanaka, S. C., Kasai, K., Okamoto, Y., Koike, S., Hayashi, T., Yamashita, A., Yamashita O. … & Hanakawa, T.:
"The status of MRI databases across the world focused on psychiatric and neurological disorders."
Psychiatry and Clinical Neurosciences, 78(10):563-57. (2024) - 3.
Fukuma, R., Majima, K., Kawahara, Y., Yamashita, O., Shiraishi, Y., Kishima, H., & Yanagisawa, T.:
"Fast, accurate, and interpretable decoding of electrocorticographic signals using dynamic mode decomposition."
Communications Biology, 7(1), 595. (2024) - 4.
Endo, H., Ikeda, S., Harada, K., Yamagata, H., Matsubara, T., Matsuo, K., … & Yamashita, O.:
"Manifold alteration between major depressive disorder and healthy control subjects using dynamic mode decomposition in resting-state fMRI data."
Frontiers in Psychiatry, 15, 1288808. (2024) - 5.
Ajioka, T, Nakai, N, Yamashita, O, Takumi, T.:
"End-to-end deep learning approach to mouse behavior classification from cortex-wide calcium imaging."
PLoS Comput Biol 20(3): e1011074. (2024) - 6.
Takeda, Y., Gomi, T., Umebayashi, R., Tomita, S., Suzuki, K., Hiroe, N., … & Yamashita, O.:
"Sensor array design of optically pumped magnetometers for accurately estimating source currents."
NeuroImage, 277, 120257. (2023) - 7.
Bai, W., Yamashita, O., & Yoshimoto, J.:
"Learning task-agnostic and interpretable subsequence-based representation of time series and its applications in fMRI analysis."
Neural Networks, 163, 327-340. (2023) - 8.
Nakai, N., Sato, M., Yamashita, O., Sekine, Y., Fu, X., Nakai, J., … & Takumi, T.:
"Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism."
Cell Reports. (2023) - 9.
Hyvärinen, A., Khemakhem, I., Morioka, H.:
"Nonlinear Independent Component Analysis for Principled Disentanglement in Unsupervised Deep Learning."
Patterns, Vol. 4, Issue 10, 100844, (2023) - 10.
Morioka, H., Hyvärinen, A.:
"Causal Representation Learning Made Identifiable by Grouping of Observational Variables."
The 41st International Conference on Machine Learning (ICML2024),(2024)
Related Links
Lab Members
Principal investigator
- Okito Yamashita
- Team Director
Core members
- Yusuke Takeda
- Research Scientist
- Yuanhao Li
- Postdoctoral Researcher
- Aapo Johannes Hyvaerinen
- Senior Visiting Scientist
- Shigeyuki Ikeda
- Visiting Scientist
- Victor Lopez Madrona
- Visiting Researcher
- Masato Uehara
- Research Part-time Worker I
Contact Information
2-2-2 Hikaridai,
Seika-cho, Souraku-gun, Kyoto
Email: okito.yamashita@riken.jp