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RIKEN Center for Advanced Intelligence Project Statistical Genetics Team

Team Leader: Gen Tamiya (Ph.D.)

Research Summary

Gen  Tamiya(Ph.D.)

Using AI-based methods in statistical genetics, we analyze Big Data consisting of a wide variety of information such as genomic variations, lifestyle and health status together with an enormous medical literature in order to identify causal factors for complex common diseases. We aim to enable genomic risk prediction for complex common diseases and then to realize personalized and preventive medicine. Chiefly we investigate Big Data from large-scale prospective genomic cohorts such as the Tohoku Medical Megabank organization.

Main Research Fields

  • Molecular Biology & Genetics

Related Research Fields

  • Clinical Medicine
  • Agricultural Sciences
  • Computer Science
  • Mathematics

Research Subjects

  • Statistical genetics of prospective genomic cohort

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Ueki, M., and Tamiya, G.:
    "Smooth-threshold multivariate genetic prediction with unbiased model selection"
    Genet Epidemiol 40(3): 233-43 (2016)
  • 2.*Kuriyama, S., Yaegashi, N., et al. (Tamiya, G.; 11th in 58 authors):
    "The Tohoku Medical Megabank Project: Design and Mission"
    J Epidemiol 26(9): 493–511 (2016)
  • 3.*Tamiya, G., Makino, S., Hayashi, M., Abe, A., Numakura, C., Ueki, M., Tanaka, A., Ito, C., Toshimori, K., Ogawa, N., Terashima, T., Maegawa, H., Yanagisawa, D., Tooyama, I., Tada, M., Onodera, O., and Hayasaka, K.:
    “A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease“
    Am J Hum Genet 95(3):294-300 (2014)
  • 4.*Yamagata University Genomic Cohort Consortium.:
    "Pleiotropic Effect of Common Variants at ABO Glycosyltranferase Locus in 9q32 on Plasma Levels of Pancreatic Lipase and Angiotensin Converting Enzyme"
    PLoS ONE 9(2):e55903 (2014)
  • 5.*Ueki, M., and Tamiya, G.:
    "Ultrahigh-dimensional variable selection method for whole-genome gene-gene interaction analysis"
    BMC Bioinformatics 13(1):72 (2012)
  • 6.*Ueta, M., Tamiya, G., Tokunaga, K., Sotozono, C., Ueki, M., Sawai, H., Inatomi, T., Matsuoka, T., Akira, S., Narumiya, S., Tashiro, K., Kinoshita, S.:
    “Epistatic interaction between TLR3 and PTGER3 genes”
    J Allergy Clin Immunol 129(5):1413-1416 (2012)
  • 7.*Tamiya, G.:
    "Transcriptional dysregulation: a cause of dystonia?"
    Lancet Neurol 8(5):416-8 (2009)
  • 8.*Makino, S., Kaji, R., Ando, S., Tomizawa, M., Yasuno, K., Goto, S., Matsumoto, S., Tabuena, D., Maranon, E., Dantes, M., Lee, LV., Ogasawara, K., Tooyama, I., Akatsu, H., Nishimura, M., Tamiya, G.:
    "Reduced Neuron-specific Expression of the TAF1 Gene Is Associated with X-linked Dystonia-Parkinsonism"
    Am J Hum Genet 80(3):393-406 (2007)
  • 9.*Katoh, T., Mano, S., Ikuta, T., Munkhbat, B., Tounai, K., Ando, H., Munkhtuvshin, N., Imanishi, T., Inoko, H., Tamiya, G.:
    "Genetic isolates in East Asia: a study of linkage disequilibrium in the X chromosome"
    Am J Hum Genet 71(2):395-400 (2002)
  • 10.*The MHC sequencing consortium.:
    "Complete sequence and gene map of a human major histocompatibility complex"
    Nature 401(6756):921-3 (1999)

Related Links

Lab Members

Principal investigator

Gen Tamiya
Team Leader

Core members

Motomichi Matsuzaki
Research Scientist
Rieko Sakurai
Postdoctoral Researcher
Kenji Yano
Postdoctoral Researcher


Position Deadline
Seeking a Research Scientist or Postdoctral Researcher (W20027) Open until filled

Contact Information

Email: gen.tamiya [at] riken.jp