RIKEN Center for Biosystems Dynamics Research Laboratory for AI Biology

Team Director: Haruka Ozaki (Ph.D.)

Japanese Page

Research Summary

Through AI biology, we aim to create an environment in life sciences research where AI and robotics are a commonplace part of everyday work. By developing, implementing, and validating these technologies in real life settings for life science research, we seek to demonstrate a range of new possibilities achievable only through non-human approaches like AI and robotics. Furthermore, we aspire to establish new theories and academic disciplines with these findings.

Main Research Fields

Complex Systems

Related Research Fields

Informatics
Biological Sciences
Biology
Life, health and medical informatics-related
System genome science-related

Keywords

AI Biology
Laboratory Automation
Research Automation
Informatics for cell

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. *Matsuzawa R, Kawahara D, Kashima M, et al.
"tomoseqr: A Bioconductor package for spatial reconstruction and visualization of 3D gene expression patterns based on RNA tomography."
PLOS ONE 20(1), e0311296 (2025) doi: 10.1371/journal.pone.0311296
2. *Nakata S, Iwasaki K, Funato H, et al.
"Neuronal subtype-specific transcriptomic changes in the cerebral neocortex associated with sleep pressure."
Neuroscience Research 207, 13-25 (2024) doi: 10.1016/j.neures.2024.03.004
3. *Tahara S, Tsuchiya T, Matsumoto H, Ozaki H.
"Transcription factor-binding k-mer analysis clarifies the cell type dependency of binding specificities and cis-regulatory SNPs in humans."
BMC Genomics 24(1), 597 (2023) doi: 10.1186/s12864-023-09692-9
4. Arai Y, Takahashi K, Horinouchi T, et al.
"SAGAS: Simulated annealing and greedy algorithm scheduler for laboratory automation."
SLAS Technology 28(4), 264-277 (2023) doi: 10.1016/j.slast.2023.03.001
5. *Tsuchiya T, Hori H, Ozaki H.
"CCPLS reveals cell-type-specific spatial dependence of transcriptomes in single cells."
Bioinformatics 38(21), 4868-4877 (2022) doi: 10.1093/bioinformatics/btac599
6. Itoh TD, Horinouchi T, Uchida H, et al.
"Optimal Scheduling for Laboratory Automation of Life Science Experiments with Time Constraints."
SLAS Technology 26(6), 650-659 (2021) doi: 10.1177/24726303211021790
7. *Minoshima F, Ozaki H, Odaka H, Tateno H.
"Integrated analysis of glycan and RNA in single cells."
iScience 24(8), 102882 (2021) doi: 10.1016/j.isci.2021.102882
8. Ozaki H, Hayashi T, Umeda M, Nikaido I.
"Millefy: visualizing cell-to-cell heterogeneity in read coverage of single-cell RNA sequencing datasets."
BMC Genomics 21(1), 177 (2020) doi: 10.1186/s12864-020-6542-z

Lab Members

Principal investigator

Haruka Ozaki: Team Director

Core members

Miwa Elharar: Assistant

Contact Information

Integrated Innovation Building
6-7-1 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Email: ai-biology@ml.riken.jp