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RIKEN Center for Biosystems Dynamics Research Laboratory for Chemical Biology

Team Leader: Takamitsu Hosoya (Ph.D.)

Research Summary

Takamitsu  Hosoya(Ph.D.)

In order to achieve the promotion of human live science and drug discovery, it is necessary to develop new methods and tools realized by the innovative chemistries. Through the researches under collaboration with a number of scientists of different disciplines, we are looking to face with significant challenges including development of useful PET probes for in vivo imaging of target molecules, novel strategies for efficient PET probe synthesis, chemical tools and methods that facilitate chemical biology researches, and development of efficient synthetic methods of valuable compounds.

Main Research Fields

  • Chemistry

Related Research Fields

  • Medicine, Dentistry & Pharmacy


  • Engineering
  • Biology & Biochemistry
  • Pharmacology & Toxicology
  • Clinical Medicine
  • Neuroscience & Behavior

Selected Publications

  • 1.Sumida, Y., Sumida, T., Hosoya, T.:
    "Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides"
    Synthesis, 49 (16), 3582–3589 (2017).
  • 2.Niwa, T., Ochiai, H., Isoda, M., Hosoya, T.:
    "Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters"
    Chem. Lett. 46 (9), 1315–1318 (2017).
  • 3.Niwa, T., Ochiai, H., Hosoya, T.:
    "Copper-Catalyzed ipso-Borylation of Fluoroarenes"
    ACS Catal. 7(7), 4535-4541 (2017).
  • 4.Ochiai, H., Uetake, Y., Niwa, T., Hosoya, T.:
    "Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carbocyclic Acids"
    Angew. Chem., Int. Ed. 56(9), 2482-2486 (2017).
  • 5.Ochiai, H., Niwa, T., Hosoya, T.:
    "Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N-Dimethylformamide"
    Org. Lett. 18(23), 5982-5985 (2016).
  • 6.Sumida, Y., Sumida, T., Hashizume, D., Hosoya, T.:
    "Preparation of Aryne-Nickel Complexes from ortho-Borylaryl Triflates"
    Org. Lett. 18(21), 5600-5603 (2016).
  • 7.Uetake, Y., Niwa, T., Hosoya, T.:
    "Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-F Bond Cleavage"
    Org. Lett. 18(11), 2758-2761 (2016)
  • 8.Niwa, T., Ochiai, H., Watanabe, Y., Hosoya, T.:
    "Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalization"
    J. Am. Chem. Soc. 137(45), 14313-14318 (2015).
  • 9.Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X. L., Watanabe, Y., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., Watanabe, Y.:
    "[11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain."
    J. Nucl. Med. 55(5), 852-857 (2014).
  • 10.Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., Hosoya, T.:
    "Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain."
    Bioorg. Med. Chem. 19(4), 1464-1470 (2011).

Recent Research Results

Related Links

Lab Members

Principal investigator

Takamitsu Hosoya
Team Leader

Core members

Zhouen Zhang
Research Scientist
Kenji Watanabe
Research Scientist
Tetsuya Hori
Senior Research Scientist
Daichi Nakamura
Postdoctoral Researcher
Junpei Tsuda
Temporary Staffing
Tadashi Takimoto
Temporary Staffing
Takashi Niwa
Visiting Scientist
Yuto Sumida
Visiting Scientist
Isao Kii
Visiting Scientist
Yuta Uetake
Visiting Scientist
Yoko Nagatomo
Kimiko Utsumi

Contact Information

6-7-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047, Japan
Email: takamitsu.hosoya [at] riken.jp