RIKEN Center for Biosystems Dynamics Research Laboratory for Chemical Biology
Team Leader: Takamitsu Hosoya (Ph.D.)
Research Summary

In order to achieve the promotion of human live science and drug discovery, it is necessary to develop new methods and tools realized by the innovative chemistries. Through the researches under collaboration with a number of scientists of different disciplines, we are looking to face with significant challenges including development of useful PET probes for in vivo imaging of target molecules, novel strategies for efficient PET probe synthesis, chemical tools and methods that facilitate chemical biology researches, and development of efficient synthetic methods of valuable compounds.
Main Research Fields
- Chemistry
Related Research Fields
- Medicine, Dentistry & Pharmacy
Keywords
- Engineering
- Biology & Biochemistry
- Pharmacology & Toxicology
- Clinical Medicine
- Neuroscience & Behavior
Selected Publications
- 1.Sumida, Y., Sumida, T., Hosoya, T.:
"Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides"
Synthesis, 49 (16), 3582–3589 (2017). - 2.Niwa, T., Ochiai, H., Isoda, M., Hosoya, T.:
"Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters"
Chem. Lett. 46 (9), 1315–1318 (2017). - 3.Niwa, T., Ochiai, H., Hosoya, T.:
"Copper-Catalyzed ipso-Borylation of Fluoroarenes"
ACS Catal. 7(7), 4535-4541 (2017). - 4.Ochiai, H., Uetake, Y., Niwa, T., Hosoya, T.:
"Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carbocyclic Acids"
Angew. Chem., Int. Ed. 56(9), 2482-2486 (2017). - 5.Ochiai, H., Niwa, T., Hosoya, T.:
"Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N-Dimethylformamide"
Org. Lett. 18(23), 5982-5985 (2016). - 6.Sumida, Y., Sumida, T., Hashizume, D., Hosoya, T.:
"Preparation of Aryne-Nickel Complexes from ortho-Borylaryl Triflates"
Org. Lett. 18(21), 5600-5603 (2016). - 7.Uetake, Y., Niwa, T., Hosoya, T.:
"Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-F Bond Cleavage"
Org. Lett. 18(11), 2758-2761 (2016) - 8.Niwa, T., Ochiai, H., Watanabe, Y., Hosoya, T.:
"Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalization"
J. Am. Chem. Soc. 137(45), 14313-14318 (2015). - 9.Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X. L., Watanabe, Y., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., Watanabe, Y.:
"[11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain."
J. Nucl. Med. 55(5), 852-857 (2014). - 10.Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., Hosoya, T.:
"Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain."
Bioorg. Med. Chem. 19(4), 1464-1470 (2011).
Recent Research Results
Aug. 30, 2019
Doubling down on boron to make complex organic molecules
Related Links
Lab Members
Principal investigator
- Takamitsu Hosoya
- Team Leader
Core members
- Zhouen Zhang
- Research Scientist
- Kenji Watanabe
- Research Scientist
- Tetsuya Hori
- Senior Research Scientist
- Daichi Nakamura
- Postdoctoral Researcher
- Junpei Tsuda
- Temporary Staffing
- Tadashi Takimoto
- Temporary Staffing
- Takashi Niwa
- Visiting Scientist
- Yuto Sumida
- Visiting Scientist
- Isao Kii
- Visiting Scientist
- Yuta Uetake
- Visiting Scientist
- Yoko Nagatomo
- Assistant
- Kimiko Utsumi
- Assistant
Contact Information
6-7-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047, Japan
Email: takamitsu.hosoya [at] riken.jp