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RIKEN Center for Biosystems Dynamics Research Laboratory for Chemical Biology

Team Leader: Takamitsu Hosoya (Ph.D.)

Research Summary

Takamitsu  Hosoya(Ph.D.)

In order to achieve the promotion of human live science and drug discovery, it is necessary to develop new methods and tools realized by the innovative chemistries. Through the researches under collaboration with a number of scientists of different disciplines, we are looking to face with significant challenges including development of useful PET probes for in vivo imaging of target molecules, novel strategies for efficient PET probe synthesis, chemical tools and methods that facilitate chemical biology researches, and development of efficient synthetic methods of valuable compounds.

Main Research Fields

  • Chemistry

Related Research Fields

  • Medicine, Dentistry & Pharmacy

Keywords

  • Engineering
  • Biology & Biochemistry
  • Pharmacology & Toxicology
  • Clinical Medicine
  • Neuroscience & Behavior

Selected Publications

  • 1.Sumida, Y., Sumida, T., Hosoya, T.:
    "Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides"
    Synthesis, 49 (16), 3582–3589 (2017).
  • 2.Niwa, T., Ochiai, H., Isoda, M., Hosoya, T.:
    "Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters"
    Chem. Lett. 46 (9), 1315–1318 (2017).
  • 3.Niwa, T., Ochiai, H., Hosoya, T.:
    "Copper-Catalyzed ipso-Borylation of Fluoroarenes"
    ACS Catal. 7(7), 4535-4541 (2017).
  • 4.Ochiai, H., Uetake, Y., Niwa, T., Hosoya, T.:
    "Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carbocyclic Acids"
    Angew. Chem., Int. Ed. 56(9), 2482-2486 (2017).
  • 5.Ochiai, H., Niwa, T., Hosoya, T.:
    "Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N-Dimethylformamide"
    Org. Lett. 18(23), 5982-5985 (2016).
  • 6.Sumida, Y., Sumida, T., Hashizume, D., Hosoya, T.:
    "Preparation of Aryne-Nickel Complexes from ortho-Borylaryl Triflates"
    Org. Lett. 18(21), 5600-5603 (2016).
  • 7.Uetake, Y., Niwa, T., Hosoya, T.:
    "Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-F Bond Cleavage"
    Org. Lett. 18(11), 2758-2761 (2016)
  • 8.Niwa, T., Ochiai, H., Watanabe, Y., Hosoya, T.:
    "Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalization"
    J. Am. Chem. Soc. 137(45), 14313-14318 (2015).
  • 9.Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X. L., Watanabe, Y., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., Watanabe, Y.:
    "[11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain."
    J. Nucl. Med. 55(5), 852-857 (2014).
  • 10.Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., Hosoya, T.:
    "Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain."
    Bioorg. Med. Chem. 19(4), 1464-1470 (2011).

Recent Research Results

Related Links

Lab Members

Principal investigator

Takamitsu Hosoya
Team Leader

Core members

Kenji Watanabe
Research Scientist
Daichi Nakamura
Postdoctoral Researcher
Emi Hayashinaka
Expert Technician
Wakiko Arakaki
Technical Staff I
Yasuhiro Wada
Temporary Employee
Kayo Onoe
Temporary Employee
Maya Mitsuno
Administrative Part-time Worker II
Kunpei Kawakatsu
Junior Research Associate
Junpei Tsuda
Temporary Staffing
Tadashi Takimoto
Temporary Staffing
Yasuyoshi Watanabe
Senior Visiting Scientist
Yosky Kataoka
Senior Visiting Scientist
Hisashi Doi
Senior Visiting Scientist
Yi Long Cui
Senior Visiting Scientist
Kei Mizuno
Senior Visiting Scientist
Mitsuyo Maeda
Senior Visiting Scientist
Takashi Niwa
Visiting Scientist
Yuto Sumida
Visiting Scientist
Isao Kii
Visiting Scientist
Yuta Uetake
Visiting Scientist
Zhouen Zhang
Visiting Scientist
Hidefumi Mukai
Visiting Scientist
Kayo Takahashi
Visiting Scientist
Hiroshi Mizuma
Visiting Scientist
Kota Mori
Visiting Scientist
Shota Warashina
Visiting Scientist
Shoko Nomura
Visiting Scientist
Tsuyoshi Tahara
Visiting Scientist
Yasuhisa Tamura
Visiting Scientist
Masanori Yamato
Visiting Scientist
Toshiyuki Goto
Visiting Scientist
Di Hu
Visiting Scientist
Yuzuru Sato
Visiting Scientist
Hiroyuki Neyama
Visiting Scientist
Shino Owada
Visiting Technician
Sally Danno
Visiting Technician
Kumi Tsutsumi
Visiting Technician
Chie Ueta
Visiting Technician
Asami Eguchi
Visiting Technician
Mayako Okamoto
Visiting Technician
Yoko Nagatomo
Assistant

Contact Information

6-7-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047, Japan
Email: takamitsu.hosoya [at] riken.jp

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