Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Nishiyama C, Saito Y, Sakaguchi A, Kaneko M, Kiyonari H, Xu Y, Arima Y, Uosaki H, Kimura W.:
  "Prolonged Myocardial Regenerative Capacity in Neonatal Opossum"
  Circulation 146, 125-139 (2022)
• 2. Saito, Y. and Kimura, W.:
  "Roles of phase separation for cellular redox maintenance",
  Front. Genet. 12, 691946 (2021)
• 3. Sakaguchi, A. and Kimura, W.:
  "Metabolic regulation of cardiac regeneration: oles of hypoxia, energy homeostasis, and mitochondrial dynamics",
  Curr. Opin. Genet. Dev. 70, 54-60 (2021)
• 4. Sakaguchi, A., Nishiyama C. and Kimura, W.:
  "Cardiac Regeneration as an Environmental Adaptation."
  Biochim. Biophys.Acta Mol. Cell Res. 1867(4):118623 (2020)
• 5.*Nakada, Y., Canseco, D. C., Thet S., Abdisalaam S., Asaithaymby A., Santos C. X., Shah A., Zhang, H., Faber, J. E., Kinter M. T., Szweda, L. I., Xing, C., Deberardinis, R., Oz O., Lu Z., Zhang C. C., #Kimura, W. and #Sadek, H. A.;
  "Hypoxia induces heart regeneration in adult mice"
  Nature 541, 222-227 (2017)
• 6.*Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C. C. and Sadek, H. A.:
  "Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart"
  Nature 523, 226-230 (2015)
• 7. *Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby. A., Mammen, P. P. and Sadek, H. A.:
  "Human ventricular unloading induces cardiomyocyte proliferation"
  J. Am. Coll. Cardiol. 65, 892-900 (2015)
• 8. *Puente, B. N., *Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M., Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. and Sadek, H. A.:
  "The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response"
  Cell 157, 565-579 (2014)

Recent Research Results

• 

  Aug. 25, 2022
  Harnessing the heart regeneration ability of marsupials

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