Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Saito, Y., Sugiura, Y., Sakaguchi, A., Sada, T., Nishiyama, C., Maeda, R., Kaneko, M., Kiyonari,H. and Kimura, W.:
  "Postnatal xanthine metabolism regulates cardiac regeneration in mammals."
  Redox Biol. 79: 103442 (2025)
• 2. *Xiao, F., Nguyen, N., Wang, P., Li, S., Thet, S., Kimura, W., Luo, X., Lam, N., ElHelaly, W. Singh, R., Hsu, C., Ladha, F., Kanchwala, M., Hill, J., Menendez-Montes, I., Cardoso, A., Helena Pereira, A., Xing, C., Hajjar, R., Sadayappan, S., Hinson, J., and Sadek H. A.:
  "Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis."
  Circulation Sep 3;150(10):791-805(2024)
• 3. Kawakami, S., Yoshitane, H., Morimura, T., Kimura, W. and Fukada, Y.:
  "Diurnal shift of mouse activity by the deficiency of an ageing-related gene Lmna."
  J. Biochem.171, 509-518 (2022)
• 4. Nishiyama C, Saito Y, Sakaguchi A, Kaneko M, Kiyonari H, Xu Y, Arima Y, Uosaki H, Kimura W.:
  "Prolonged Myocardial Regenerative Capacity in Neonatal Opossum"
  Circulation 146, 125-139 (2022)
• 5. Iwasa, N., Matsui, T. K., Iguchi, N., Kinugawa, K., Morikawa, N., Sakaguchi, Y. M., Shiota, T., Kobashigawa, S., Nakanishi, M., Matsubayashi, M., Eura, N., Kiriyama, T., Izumi, T., Saito, K., Kataoka, H., Saito, Y., Kimura, W., Nishimura, Y., Mori, E., Sugie, K.:
  "Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation."
  Front. Cell Neurosci. 15, 605030 (2021)
• 6. Sakaguchi, A., Kawasaki, M., Saito, Y., Murata, K., Masumoto, H. and Kimura, W.:
  "Benzyl isothiocyanate induces cardiomyocyte proliferation and heart regeneration."
  bioRxiv 09.08.459197(2021)
• 7. *Nakada, Y., Canseco, D. C., Thet S., Abdisalaam S., Asaithaymby A., Santos C. X., Shah A., Zhang, H., Faber, J. E., Kinter M. T., Szweda, L. I., Xing, C., Deberardinis, R., Oz O., Lu Z., Zhang C. C., #Kimura, W. and #Sadek, H. A.;
  "Hypoxia induces heart regeneration in adult mice"
  Nature 541, 222-227 (2017)
• 8.*Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C. C. and Sadek, H. A.:
  "Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart"
  Nature 523, 226-230 (2015)
• 9. *Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby. A., Mammen, P. P. and Sadek, H. A.:
  "Human ventricular unloading induces cardiomyocyte proliferation"
  J. Am. Coll. Cardiol. 65, 892-900 (2015)
• 10. *Puente, B. N., *Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M., Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. and Sadek, H. A.:
  "The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response"
  Cell 157, 565-579 (2014)

Recent Research Results

• 

  Aug. 25, 2022
  Harnessing the heart regeneration ability of marsupials

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