1. Home
  2. Research
  3. Centers & Labs
  4. RIKEN Center for Biosystems Dynamics Research

RIKEN Center for Biosystems Dynamics Research Laboratory for Heart Regeneration

Team Leader: Wataru Kimura (Ph.D.)

Research Summary

Wataru  Kimura(Ph.D.)

Heart disease is the number one killer of humankind mainly because the heart does not have regenerative capabilities. Our previous study indicated that oxidative stress is the main inducer of cell cycle arrest in postnatal mammalian heart muscle cells, cardiomyocytes. Our research interest is focused on why postnatal mammalian cardiomyocytes do not proliferate after injury- and age-related myocardial damage, and whether it is possible to re-awaken endogenous regenerative capacity. We utilize molecular and cellular tools and mouse genetics to understand the role of oxidative metabolism in cardiomyocyte cell cycle regulation throughout the life cycle of mammals.

Main Research Fields

  • Biology

Related Research Fields

  • Medicine, Dentistry & Pharmacy


  • myocardial regeneration
  • oxidative stress
  • DNA damage
  • cell cycle

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Nishiyama C, Saito Y, Sakaguchi A, Kaneko M, Kiyonari H, Xu Y, Arima Y, Uosaki H, Kimura W.:
    "Prolonged Myocardial Regenerative Capacity in Neonatal Opossum"
    Circulation 146, 125-139 (2022)
  • 2. Saito, Y. and Kimura, W.:
    "Roles of phase separation for cellular redox maintenance",
    Front. Genet. 12, 691946 (2021)
  • 3. Sakaguchi, A. and Kimura, W.:
    "Metabolic regulation of cardiac regeneration: oles of hypoxia, energy homeostasis, and mitochondrial dynamics",
    Curr. Opin. Genet. Dev. 70, 54-60 (2021)
  • 4. Sakaguchi, A., Nishiyama C. and Kimura, W.:
    "Cardiac Regeneration as an Environmental Adaptation."
    Biochim. Biophys.Acta Mol. Cell Res. 1867(4):118623 (2020)
  • 5.*Nakada, Y., Canseco, D. C., Thet S., Abdisalaam S., Asaithaymby A., Santos C. X., Shah A., Zhang, H., Faber, J. E., Kinter M. T., Szweda, L. I., Xing, C., Deberardinis, R., Oz O., Lu Z., Zhang C. C., #Kimura, W. and #Sadek, H. A.;
    "Hypoxia induces heart regeneration in adult mice"
    Nature 541, 222-227 (2017)
  • 6.*Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C. C. and Sadek, H. A.:
    "Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart"
    Nature 523, 226-230 (2015)
  • 7. *Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby. A., Mammen, P. P. and Sadek, H. A.:
    "Human ventricular unloading induces cardiomyocyte proliferation"
    J. Am. Coll. Cardiol. 65, 892-900 (2015)
  • 8. *Puente, B. N., *Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M., Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. and Sadek, H. A.:
    "The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response"
    Cell 157, 565-579 (2014)

Recent Research Results

Related Links

Lab Members

Principal investigator

Wataru Kimura
Team Leader

Core members

Akane Sakaguchi
Research Scientist
Yuichi Saito
Special Postdoctoral Researcher
Nobutoshi Ota
Research Scientist
Chihiro Nishiyama
Technical Staff I
Miwa Kawasaki
Technical Staff I
Tai Sada
Junior Research Associate
Taketo Fukuhara
Student Trainee

Contact Information

4F, RIKEN BDR Developmental Biology Bldg.A,
2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan
Email: wataru.kimura [at] riken.jp