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RIKEN Center for Biosystems Dynamics Research Laboratory for Neural Stem Cell Research

Team Director: Ryoichiro Kageyama (M.D., Ph.D.)

Research Summary

Ryoichiro Kageyama (M.D., Ph.D.)

We are analyzing the regulatory mechanism of proliferation and differentiation of neural stem cells (NSCs). Embryonic NSCs proliferate intensively and give rise to various types of neurons and glial cells, thereby forming complex brain structures, whereas adult NSCs lose such proliferation and differentiation competencies and therefore cannot regenerate diseased or damaged brain tissues. We aim to elucidate the genetic-level differences between embryonic and adult NSCs and establish the technical basis for brain tissue regeneration.

Main Research Fields

  • Biological Sciences

Related Research Fields

  • Biology
  • Medicine, Dentistry & Pharmacy
  • Neuroscience
  • Developmental biology

Keywords

  • Neural stem cell
  • Neural regeneration
  • Adult neurogenesis

Selected Publications

  • 1. Isomura A, Kageyama R.
    "Progress in understanding the vertebrate segmentation clock"
    Nature Reviews Genetics (2025) doi: 10.1038/s41576-025-00813-6
  • 2. Shimojo H, Masaki T, Kageyama R.
    "The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells."
    Developmental Cell 59(15), 1913-1923 (2024) doi: 10.1016/j.devcel.2024.04.019
  • 3. Maeda Y, Isomura A, Masaki T, Kageyama R.
    "Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21."
    Cell Reports 42(5), 112520 (2023) doi: 10.1016/j.celrep.2023.112520
  • 4. Kageyama R.
    "In retrospect: 25 years of the segmentation clock gene"
    Nature 611, 671-673 (2022) doi: 10.1038/d41586-022-03562-2
  • 5. Kaise T, Fukui M, Sueda R, et al.
    "Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity"
    Genes and Development 36, 23-37 (2022) doi: 10.1101/gad.349000.121
  • 6. Matsuda M, Hayashi H, Garcia-Ojalvo J, et al.
    "Species-specific segmentation clock periods are due to differential biochemical reaction speeds."
    Science 369(6510), 1450-1455 (2020) doi: 10.1126/science.aba7668
  • 7. Yoshioka-Kobayashi K, Matsumiya M, Niino Y, et al.
    "Coupling delay controls synchronized oscillation in the segmentation clock."
    Nature 580(7801), 119-123 (2020) doi: 10.1038/s41586-019-1882-z
  • 8. Diaz-Cuadros M, Wagner DE, Budjan C, et al.
    "In vitro characterization of the human segmentation clock."
    Nature 580(7801), 113-118 (2020) doi: 10.1038/s41586-019-1885-9
  • 9. Sueda R, Imayoshi I, Harima Y, Kageyama R.
    "High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain."
    Genes & Development 33(9-10), 511-523 (2019) doi: 10.1101/gad.323196.118
  • 10. Kawaguchi K, Kageyama R, Sano M.
    "Topological defects control collective dynamics in neural progenitor cell cultures."
    Nature 545(7654), 327-331 (2017) doi: 10.1038/nature22321

Recent Research Results

Lab Members

Principal investigator

Ryoichiro Kageyama
Team Director

Contact Information

2-2-3 Minatojima-minamimachi,
Chuo-ku, Kobe, Hyogo 650-0047
Email: ryoichiro.kageyama@riken.jp

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