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RIKEN Center for Biosystems Dynamics Research Laboratory for Nutritional Biology

Team Leader: Fumiaki Obata (Ph.D.)

Research Summary

Fumiaki Obata (Ph.D.)

The organismal healthspan is significantly influenced by the quality and quantity of the diet, but our understanding of the detailed molecular mechanisms remains limited. In our laboratory, we study the physiological functions of various nutrients during each life stage, including development, growth, reproduction, and aging. We aim to elucidate the adaptive mechanisms in response to nutritional imbalances, whether transient or chronic, and their impact on molecular mechanisms related to metabolic physiology, tissue homeostasis, feeding behavior, stress response, reproductive capacity, and overall lifespan.

Main Research Fields

  • Biology

Related Research Fields

  • Agricultural Sciences
  • Biological Sciences
  • Medicine, Dentistry & Pharmacy
  • Environmental physiology
  • Developmental biology
  • Biological pharmacy


  • Nutrition
  • Lifespan
  • Gut microbiota
  • Metabolism
  • Innate Immunity

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Kosakamoto H, Miura M, Obata F.
    "Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila."
    Development 151(1), dev202372 (2024) doi: 10.1242/dev.202372
  • 2. Kosakamoto H, Obata F, Kuraishi J, et al.
    "Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila."
    Nature Communications 14(1), 7832 (2023) doi: 10.1038/s41467-023-43550-2
  • 3. Onuma T, Yamauchi T, Kosakamoto H, et al.
    "Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan."
    PLOS Genetics 19(4), e1010709 (2023) doi: 10.1371/journal.pgen.1010709
  • 4. Kosakamoto H, Okamoto N, Aikawa H, et al.
    "Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila."
    Nature Metabolism 4(7), 944-959 (2022) doi: 10.1038/s42255-022-00608-7
  • 5. *Yamauchi T, Oi A, Kosakamoto H, et al.
    "Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila."
    iScience 23, 101477 (2020) doi: 10.1016/j.isci.2020.101477
  • 6. *Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
    "Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila."
    Cell Reports 32(3), 107938 (2020) doi: 10.1016/j.celrep.2020.107938
  • 7. *Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
    "Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine."
    Developmental Cell 44(6), 741-751 (2018) doi: 10.1016/j.devcel.2018.02.017
  • 8. *Obata F, Fons CO, Gould AP.
    "Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila."
    Nature Communications 9(1), 975 (2018) doi: 10.1038/s41467-018-03070-w

Recent Research Results

Related Links

Lab Members

Principal investigator

Fumiaki Obata
Team Leader

Core members

Chisako Sakuma
Research Scientist
Hina Kosakamoto
Special Postdoctoral Researcher
Ayano Oi
Student Trainee
Yusuke Kato
Junior Research Associate
Yuka Fujita
Student Trainee
Souto Kitazawa
Student Trainee
Rina Okada
Technical Staff I
Ayako Matoba
Technical Staff I
Okiko Habara
Research Part-time Worker I
Mari Shoji

Contact Information

Developmental Biology Buildings A N705
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047
Tel: +81-(0)7-8306-3368
Email: fumiaki.obata [at] riken.jp