RIKEN Center for Biosystems Dynamics Research Laboratory for Nutritional Biology
Team Leader: Fumiaki Obata (Ph.D.)
Research Summary
The organismal healthspan is significantly influenced by the quality and quantity of the diet, but our understanding of the detailed molecular mechanisms remains limited. In our laboratory, we study the physiological functions of various nutrients during each life stage, including development, growth, reproduction, and aging. We aim to elucidate the adaptive mechanisms in response to nutritional imbalances, whether transient or chronic, and their impact on molecular mechanisms related to metabolic physiology, tissue homeostasis, feeding behavior, stress response, reproductive capacity, and overall lifespan.
Main Research Fields
- Biology
Related Research Fields
- Agricultural Sciences
- Biological Sciences
- Medicine, Dentistry & Pharmacy
- Environmental physiology
- Developmental biology
- Biological pharmacy
Keywords
- Nutrition
- Lifespan
- Gut microbiota
- Metabolism
- Innate Immunity
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Kosakamoto H, Miura M, Obata F.
"Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila."
Development 151(1), dev202372 (2024) doi: 10.1242/dev.202372 - 2.
Kosakamoto H, Obata F, Kuraishi J, et al.
"Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila."
Nature Communications 14(1), 7832 (2023) doi: 10.1038/s41467-023-43550-2 - 3.
Onuma T, Yamauchi T, Kosakamoto H, et al.
"Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan."
PLOS Genetics 19(4), e1010709 (2023) doi: 10.1371/journal.pgen.1010709 - 4.
Kosakamoto H, Okamoto N, Aikawa H, et al.
"Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila."
Nature Metabolism 4(7), 944-959 (2022) doi: 10.1038/s42255-022-00608-7 - 5.
*Yamauchi T, Oi A, Kosakamoto H, et al.
"Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila."
iScience 23, 101477 (2020) doi: 10.1016/j.isci.2020.101477 - 6.
*Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
"Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila."
Cell Reports 32(3), 107938 (2020) doi: 10.1016/j.celrep.2020.107938 - 7.
*Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
"Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine."
Developmental Cell 44(6), 741-751 (2018) doi: 10.1016/j.devcel.2018.02.017 - 8.
*Obata F, Fons CO, Gould AP.
"Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila."
Nature Communications 9(1), 975 (2018) doi: 10.1038/s41467-018-03070-w
Recent Research Results
-
Mar. 26, 2024
Flies fed restricted diet in early adulthood live longer
Related Links
Lab Members
Principal investigator
- Fumiaki Obata
- Team Leader
Core members
- Chisako Sakuma
- Research Scientist
- Hina Kosakamoto
- Special Postdoctoral Researcher
- Ayano Oi
- Student Trainee
- Yusuke Kato
- Junior Research Associate
- Yuka Fujita
- Student Trainee
- Souto Kitazawa
- Student Trainee
- Rina Okada
- Technical Staff I
- Ayako Matoba
- Technical Staff I
- Okiko Habara
- Research Part-time Worker I
- Mari Shoji
- Assistant
Contact Information
Developmental Biology Buildings A N705
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047
Tel: +81-(0)7-8306-3368
Email: fumiaki.obata [at] riken.jp