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RIKEN Center for Biosystems Dynamics Research Laboratory for Nutritional Biology

Team Leader: Fumiaki Obata (Ph.D.)

Research Summary

Fumiaki Obata (Ph.D.)

Our healthspan is influenced by the dietary environment. Diet contributes to metabolic and physiological homeostasis by altering nutritional balance and gut microbiota, yet the molecular mechanisms are not fully understood. Our laboratory studies the functions of each nutrient and gut bacterial species that are dynamically altered in response to various dietary conditions. We also aim to elucidate the mechanisms by which early-life diet impacts lifelong health. Our goal is to reveal evolutionarily conserved "dietological" mechanisms that govern organismal homeostasis and healthspan.

Main Research Fields

  • Biology

Related Research Fields

  • Agricultural Sciences
  • Biological Sciences
  • Medicine, Dentistry & Pharmacy
  • Environmental physiology
  • Developmental biology
  • Biological pharmacy


  • Nutrition
  • Lifespan
  • Gut microbiota
  • Metabolism
  • Innate Immunity

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. *Yamauchi T, Oi A, Kosakamoto H, Akuzawa-Tokita Y, Murakami T, Mori H, Miura M and Obata F.:
    "Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila."
    iScience 23, 101477, 2020
  • 2. *Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, Nishimura K, Soga T, Murakami T, Mori H, Yamamoto K, Miyazaki R, Koto A, Miura M, Obata F.:
    "Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila."
    Cell Reports 32, 107938, 2020
  • 3. *Obata F, Tsuda-Sakurai K, Yamazaki T, Nishio R, Nishimura K, Kimura M, Funakoshi M, Miura M.:
    "Nutritional control of stem cell division through S-adenosylmethionine in Drosophila intestine."
    Developmental Cell 44, 741-751, 2018
  • 4. *Obata F, Fons CO, Gould AP.:
    "Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila."
    Nature Communications 9, 975, 2018
  • 5. *Obata F, Miura M.:
    "Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan."
    Nature Communications 6, 8332, 2015
  • 6. *Obata F, Tanaka S, Kashio S, Tsujimura H, Sato R, Miura M.:
    "Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor."
    BMC Biology 13, 48, 2015
  • 7. *Obata F, Kuranaga E, Tomioka K, Ming M, Takeishi A, Chen CH, Soga T, Miura M.:
    "Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis."
    Cell Reports 7, 821-833, 2014

Related Links

Lab Members

Principal investigator

Fumiaki Obata
Team Leader

Contact Information

Developmental Biology Buildings A N706
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047
Tel: +81-(0)7-8306-3368
Email: fumiaki.obata [at] riken.jp