Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Kosakamoto H, Sakuma C, Okada R, et al.
  "Context-dependent impact of the dietary non-essential amino acid tyrosine on Drosophila physiology and longevity."
  Science Advances 10(35), eadn7167 (2024) doi: 10.1126/sciadv.adn7167
• 2. Sakuma C, Iwamoto T, Masuda K, et al.
  "Fibrinopeptide A-induced blood-feeding arrest in the yellow fever mosquito Aedes aegypti".
  Cell Reports (2024) doi: 10.1016/j.celrep.2024.114354
• 3. Kosakamoto H, Miura M, Obata F.
  "Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila."
  Development 151(1), dev202372 (2024) doi: 10.1242/dev.202372
• 4. Kosakamoto H, Obata F, Kuraishi J, et al.
  "Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila."
  Nature Communications 14(1), 7832 (2023) doi: 10.1038/s41467-023-43550-2
• 5. Onuma T, Yamauchi T, Kosakamoto H, et al.
  "Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan."
  PLOS Genetics 19(4), e1010709 (2023) doi: 10.1371/journal.pgen.1010709
• 6. Kosakamoto H, Okamoto N, Aikawa H, et al.
  "Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila."
  Nature Metabolism 4(7), 944-959 (2022) doi: 10.1038/s42255-022-00608-7
• 7. *Yamauchi T, Oi A, Kosakamoto H, et al.
  "Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila."
  iScience 23, 101477 (2020) doi: 10.1016/j.isci.2020.101477
• 8. *Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
  "Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila."
  Cell Reports 32(3), 107938 (2020) doi: 10.1016/j.celrep.2020.107938
• 9. *Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
  "Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine."
  Developmental Cell 44(6), 741-751 (2018) doi: 10.1016/j.devcel.2018.02.017
• 10. *Obata F, Fons CO, Gould AP.
  "Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila."
  Nature Communications 9(1), 975 (2018) doi: 10.1038/s41467-018-03070-w

Recent Research Results

• 

  Dec. 12, 2024
  Limiting intake of a non-essential amino acid brings surprising benefits to flies

• 

  Mar. 26, 2024
  Flies fed restricted diet in early adulthood live longer

• 

  Jul. 28, 2023
  How a gut microbe causes flies to live fast and die young

• 

  Oct. 17, 2022
  ‘Non-essential’ building block proves vital to a healthy protein diet

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