研究概要

主要論文

「*」は、理研外のみでの成果です。

• 1. Taro Onuma ,Toshitaka Yamauchi ,Hina Kosakamoto, Hibiki Kadoguchi, Takayuki Kuraishi, Takumi Murakami, Hiroshi Mori, Masayuki Miura, Fumiaki Obata.:
  "Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan"
  PLOS Genetics 19(4): e1010709. (2023)
• 2. Hina Kosakamoto, Naoki Okamoto, Hide Aikawa, Yuki Sugiura, Makoto Suematsu, Ryusuke Niwa, Masayuki Miura, Fumiaki Obata.:
  "Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila."
  Nature metabolism 4, 944–959 (2022)
• 3. *Yamauchi T, Oi A, Kosakamoto H, Akuzawa-Tokita Y, Murakami T, Mori H, Miura M and Obata F.:
  "Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila."
  iScience 23, 101477, 2020
• 4. *Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, Nishimura K, Soga T, Murakami T, Mori H, Yamamoto K, Miyazaki R, Koto A, Miura M, Obata F.:
  "Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila."
  Cell Reports 32, 107938, 2020
• 5. *Obata F, Tsuda-Sakurai K, Yamazaki T, Nishio R, Nishimura K, Kimura M, Funakoshi M, Miura M.:
  "Nutritional control of stem cell division through S-adenosylmethionine in Drosophila intestine."
  Developmental Cell 44, 741-751, 2018
• 6. *Obata F, Fons CO, Gould AP.:
  "Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila."
  Nature Communications 9, 975, 2018

研究成果（プレスリリース）

• 

  2023年4月19日
  酵素発現領域を染め分ける高感度ラマンプローブの開発

• 

  2022年7月26日
  タンパク質欠乏をしのぐ栄養適応の新機構

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