Research Summary

Selected Publications

• 1. Tanaka, M., Yokoyama, T., Saito, H., Nishimoto, M., Tsuda, K., Sotta, N., Shigematsu, H., Shirouzu, M., Iwasaki, S., Ito, T. and Fujiwara, T.:
  “Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1”
  Nature Chemical Biology 20, 605-614 (2024) doi: 10.1038/s41589-023-01513-0
• 2. Kashiwagi, K., Shichino, Y., Osaki, T., Sakamoto, A., Nishimoto, M., Takahashi, M., Mito, M., Weber, F., Ikeuchi, Y., Iwasaki, S., Ito, T.:
  "eIF2B-capturing viral protein NSs suppresses the integrated stress response"
  Nature Communications 12, 7102 (2021) doi: 10.1038/s41467-021-27337-x
• 3. Zyryanova, AF., Kashiwagi, K., Rato, C., Harding, HP., Crespillo-Casado, A., Perera, LA., Sakamoto, A., Nishimoto, M., Yonemochi, M., Shirouzu, M., Ito, T., Ron, D.:
  "ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B"
  Molecular Cell 81, 88-103 (2021) doi: 10.1016/j.molcel.2020.10.031
• 4. Yokoyama, T., Machida, K., Iwasaki, W., Shigeta, T., Nishimoto, M., Takahashi, M., Sakamoto, A., Yonemochi, M., Harada, Y., Shigematsu, H., Shirouzu, M., Tadakuma, H., Imataka, H., Ito, T.:
  "HCV IRES Captures an Actively Translating 80S Ribosome"
  Molecular Cell 74, 1205-1214 (2019) doi: 10.1016/j.molcel.2019.04.022
• 5. Kashiwagi, K., Yokoyama, T., Nishimoto, M., Takahashi, M., Sakamoto, A., Yonemochi, M., Shirouzu, M., Ito, T.:
  "Structural basis for eIF2B inhibition in integrated stress response"
  Science 364, 495-499 (2019) doi: 10.1126/science.aaw4104
• 6. Iwasaki, S., Iwasaki, W., Takahashi, M., Sakamoto, A., Watanabe, C., Shichino, Y., Floor, S.N., Fujiwara, K., Mito, M., Dodo, K., Sodeoka, M., Imataka, H., Honma, T., Fukuzawa, K., Ito, T., Ingolia, N.T.:
  "The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA"
  Molecular Cell 73, 738-748 (2018) doi: 10.1016/j.molcel.2018.11.026
• 7. Kashiwagi, K., Takahashi, M., Nishimoto, M., Hiyama, T.B., Higo, T., Umehara, T., Sakamoto, K., Ito, T. and Yokoyama, S.:
  "Crystal structure of eukaryotic translation initiation factor 2B"
  Nature 531, 122-125 (2016) doi: 10.1038/nature16991
• 8. Ito, T., Masuda, I., Yoshida, K., Goto-Ito, S., Sekine, S., Suh, S.W., Hou, Y.-M. and Yokoyama, S.:
  "Structural Basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD"
  Proc Natl Acad Sci U S A. 112, E4197-E4205 (2015) doi: 10.1073/pnas.1422981112
• 9. Ito, T., Yokoyama, S.:
  "Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions"
  Nature 467, 612-616 (2010) doi: 10.1038/nature09411
• 10. Goto-Ito, S., Ito, T., Kuratani, M., Bessho, Y., Yokoyama, S.:
  "Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation"
  Nature Structural & Molecular Biology 16, 1109-1115 (2009) doi: 10.1038/nsmb.1653

Recent Research Results

• 

  Mar. 17, 2022
  A viral inhibitor of cellular stress response shows therapeutic potential

• 

  Aug. 9, 2019
  How phosphorylation of eIF2 reduces protein synthesis

• 

  Mar. 8, 2019
  Natural plant defense could lead to new personalized cancer therapy

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