RIKEN BioResource Research Center (BRC®) iPSC-based Drug Discovery and Development Team
Team Leader: Haruhisa Inoue (M.D., Ph.D.)
Research Summary

At BRC®, disease-specific iPS cells established from patients with various diseases are provided as bioresources. The disease-specific iPS cells are used for drug discovery and development.
Three missions of the team are as follows.
- iPS cells of BRC® to develop infrastructure technology for drug discovery and development
- Innovating the technology that will open an avenue for practical and general uses
- Bridging disease-specific iPS cells and academia / industry in the field of translational research
Main Research Fields
- Medicine, Dentistry & Pharmacy
Related Research Fields
- Biology
Keywords
- Disease modeling
- Drug discovery and development
- Disease-specific iPS cells
Selected Publications
- 1.
Otsuka Y, Imamura K, Oishi A, Asakawa K, Kondo T, Nakai R, Suga M, Inoue I, Sagara Y, Tsukita K, Teranaka K, Nishimura Y, Watanabe A, Umeyama K, Okushima N, Mitani K, Nagashima H, Kawakami K, Muguruma K, Tsujikawa A and Inoue H.:
"Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction"
JCI Insight (2024) - 2.
Nonaka H, Kondo T, Suga M, Yamanaka R, Sagara Y, Tsukita K, Mitsutomi N, Homma K, Saito R, Miyoshi F, Ohzeki H, Okuyama M, Inoue H.:
"Induced pluripotent stem cell-based assays recapture multiple properties of human astrocytes"
Journal of Cellular and Molecular Medicine (2024) - 3.
Suzuki H, Egawa N, Imamura K, Kondo T, Enami T, Tsukita K, Suga M, Yada Y, Shibukawa R, Takahashi R, Inoue H.:
"Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation."
Molecular Brain (2024) - 4.
Suong D, Imamura K, Kato Y, Inoue H.:
"Design of neural organoids engineered by mechanical forces."
IBRO Neuroscience Reports (2024) - 5.
Kondo T, Inoue I, Umeyama K, Watanabe M, Matsunari H, Uchikura A, Nakano K, Tsukita K, Imamura K, Nagashima H, Inoue H.:
"A Transgenic Pig Model With Human Mutant SOD1 Exhibits the Early Pathology of Amyotrophic Lateral Sclerosis."
Laboratory Investigation (2023) - 6.
Kondo T, Yada Y, Ikeuchi T, Inoue H.:
"CDiP technology for reverse engineering of sporadic Alzheimer's disease."
Journal of Human Genetic(2022) - 7.
Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Yada Y, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Tsujikawa A, Inoue H.:
"One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors"
iScience (2022) - 8.
Kondo T, Hara N, Koyama S, Yada Y, Tsukita K, Nagahashi A, Ikeuchi T, Ishii K, Asada T, Arai T, Yamada R, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Alzheimer's Disease Neuroimaging Initiative (ADNI), Inoue H.:
"Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer's disease patients"
Nature Aging (2022) - 9.
Suong D, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, Inoue H.:
"Induction of inverted morphology in brain organoids by vertical-mixing bioreactors"
Communication Biology, DOI: 10.1038/s42003-021-02719-5 (2021) - 10.
Yada Y, Suga M, Shibukawa R, Sagara Y, Okanishi Y, Enami T, Tsukita K, Kondo T, Imamura K, Sugihara G, Murai T, Inoue H.:
"Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins"
Stem Cell Research, 55: 102504, DOI: 10.1016/j.scr.2021.102504 (2021)
Publications
- Haruhisa Inoue, Yukio Nakamura (Editors):
"Medical Applications of iPS Cells - Inovation in Medical Sciences" Springer, (2019)
Related Links
- Dec. 3, 2024 BRC News Release: ”Striosome circuitry stimulation inhibits striatal dopamine release and locomotion”
- Interview with staff working in 12 laboratories (FY2024) "Supporting Drug discovery and development Research Using Disease-specific iPS cells"
- YouTube rikenchannel "〜Ecosystem for drug discovery and development〜"
- Bioresource Frontier Programs|Bioresource Research Center
- iPSC-based Drug Discovery and Development Team
- CiRA | Center for iPS Cell Research and Application, Kyoto University
Lab Members
Principal investigator
- Haruhisa Inoue
- Team Leader
Core members
- Mika Suga
- Research & Development Scientist
- Risako Nakai
- Postdoctoral Researcher
- Ran Shibukawa
- Technical Staff II
- Yukako Sagara
- Technical Staff II
- Takeshi Niki
- Technical Staff II
- Yaya Taketsuna
- Technical Staff II
Contact Information
Laboratory Wing 7F, Keihanna Plaza (Keihanna Science City)
1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan
Email: Inoue-brc@ml.riken.jp