RIKEN BioResource Research Center (BRC®) iPSC-based Drug Discovery and Development Team
Team Leader: Haruhisa Inoue (M.D., Ph.D.)
Research Summary

At BRC®, disease-specific iPS cells established from patients with various diseases are provided as bioresources. The disease-specific iPS cells are used for drug discovery and development.
Three missions of the team are as follows.
- iPS cells of BRC® to develop infrastructure technology for drug discovery and development
- Innovating the technology that will open an avenue for practical and general uses
- Bridging disease-specific iPS cells and academia / industry in the field of translational research
Main Research Fields
- Medicine, Dentistry & Pharmacy
Related Research Fields
- Biology
Keywords
- Disease modeling
- Drug discovery and development
- Disease-specific iPS cells
Selected Publications
- 1.
Kondo T, Yada Y, Ikeuchi T, Inoue H:
"CDiP technology for reverse engineering of sporadic Alzheimer’s disease."
l of Human Genetic(2022) - 2.
Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Yada Y, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Tsujikawa A, Inoue H:
"One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors"
iScience (2022) - 3.
Kondo T, Hara N, Koyama S, Yada Y, Tsukita K, Nagahashi A, Ikeuchi T, Ishii K, Asada T, Arai T, Yamada R, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Inoue H:
"Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients"
Nature Aging (2022) - 4.
Suong D, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, Inoue H:
"Induction of inverted morphology in brain organoids by vertical-mixing bioreactors"
Communication Biology, DOI: 10.1038/s42003-021-02719-5 (2021) - 5.
Ghee Wan Tan, Kondo T, Imamura K, Suga M, Enami T, Nagahashi A, Tsukita K, Inoue I, Kawaguchi J, Shu T, Inoue H;
"Simple derivation of skeletal muscle from human pluripotent stem cells using temperature-sensitive Sendai virus vector"
Journal of Cellular and Molecular Medicine, DOI: 10.1111/jcmm.16899 (2021) - 6.
Yada Y, Suga M, Shibukawa R, Sagara Y, Okanishi Y, Enami T, Tsukita K, Kondo T, Imamura K, Sugihara G, Murai T, Inoue H
"Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins"
Stem Cell Research, 55: 102504, DOI: 10.1016/j.scr.2021.102504 (2021) - 7.
Yada Y, Kondo T, Suga M, Tsukita K, Enami T, Shibukawa R, Sagara Y, Okanishi Y, Imamura K, Kihara T, Inoue H;
"Human induced pluripotent stem cells generated from a patient with idiopathic basal ganglia calcification"
Stem Cell Research,53;102274, DOI: 10.1016/j.scr.2021.102274 (2021) - 8.
Imamura K, Sakurai Y, Enami T, Shibukawa R, Nishi Y, Ohta A, Shu T, Kawaguchi J, Okada S, Hoenen T, Yasuda J, Inoue H:
"iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility"
FEBS open bio, DOI: 10.1002/2211-5463.13153, (2021) - 9.
Imamura K, Yada Y, Izumi Y, Morita M, Kawata A, Arisato T, Nagahashi A, Enami T, Tsukita K, Kawakami H, Nakagawa M, Takahashi R, Inoue H:
"Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells"
Annals of Neurology, 89(6):1226-1233, DOI:10.1002/ana.26047, (2021) - 10.
Suzuki H, Egawa N, Kondo T, Imamura K, Enami T, Tsukita K, Suga M, Shibukawa R, Okanishi Y, Uchiyama T, Inoue H:
"Generation of a human induced pluripotent stem cell line derived from a Parkinson’s disease patient carrying SNCA duplication"
Stem Cell Research, 45, doi.10.1016/j.scr.2020.101828, (2020)
Publications
- Haruhisa Inoue, Yukio Nakamura (Editors):
"Medical Applications of iPS Cells - Inovation in Medical Sciences" Springer, (2019)
Related Links
Lab Members
Principal investigator
- Haruhisa Inoue
- Team Leader
Core members
- Mika Suga
- Research & Development Scientist
- Risako Nakai
- Postdoctoral Researcher
- Ran Shibukawa
- Technical Staff II
- Yukako Sagara
- Technical Staff II
- Takeshi Niki
- Technical Staff II
Contact Information
Laboratory Wing 7F, Keihanna Plaza (Keihanna Science City)
1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan
Email: Inoue-brc [at] ml.riken.jp