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RIKEN BioResource Research Center (BRC®) iPSC-based Drug Discovery and Development Team

Team Leader: Haruhisa Inoue (M.D., Ph.D.)

Research Summary

Haruhisa  Inoue(M.D., Ph.D.)

At BRC®, disease-specific iPS cells established from patients with various diseases are provided as bioresources. The disease-specific iPS cells are used for drug discovery and development.

Three missions of the team are as follows.

  • iPS cells of BRC® to develop infrastructure technology for drug discovery and development
  • Innovating the technology that will open an avenue for practical and general uses
  • Bridging disease-specific iPS cells and academia / industry in the field of translational research

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology


  • Disease modeling
  • Drug discovery and development
  • Disease-specific iPS cells

Selected Publications

  • 1. Kondo T, Yada Y, Ikeuchi T, Inoue H:
    "CDiP technology for reverse engineering of sporadic Alzheimer’s disease."
    l of Human Genetic(2022)
  • 2. Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Yada Y, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Tsujikawa A, Inoue H:
    "One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors"
    iScience (2022)
  • 3. Kondo T, Hara N, Koyama S, Yada Y, Tsukita K, Nagahashi A, Ikeuchi T, Ishii K, Asada T, Arai T, Yamada R, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Inoue H:
    "Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients"
    Nature Aging (2022)
  • 4. Suong D, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, Inoue H:
    "Induction of inverted morphology in brain organoids by vertical-mixing bioreactors"
    Communication Biology, DOI: 10.1038/s42003-021-02719-5 (2021)
  • 5. Ghee Wan Tan, Kondo T, Imamura K, Suga M, Enami T, Nagahashi A, Tsukita K, Inoue I, Kawaguchi J, Shu T, Inoue H;
    "Simple derivation of skeletal muscle from human pluripotent stem cells using temperature-sensitive Sendai virus vector"
    Journal of Cellular and Molecular Medicine, DOI: 10.1111/jcmm.16899 (2021)
  • 6. Yada Y, Suga M, Shibukawa R, Sagara Y, Okanishi Y, Enami T, Tsukita K, Kondo T, Imamura K, Sugihara G, Murai T, Inoue H
    "Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins"
    Stem Cell Research, 55: 102504, DOI: 10.1016/j.scr.2021.102504 (2021)
  • 7. Yada Y, Kondo T, Suga M, Tsukita K, Enami T, Shibukawa R, Sagara Y, Okanishi Y, Imamura K, Kihara T, Inoue H;
    "Human induced pluripotent stem cells generated from a patient with idiopathic basal ganglia calcification"
    Stem Cell Research,53;102274, DOI: 10.1016/j.scr.2021.102274 (2021)
  • 8. Imamura K, Sakurai Y, Enami T, Shibukawa R, Nishi Y, Ohta A, Shu T, Kawaguchi J, Okada S, Hoenen T, Yasuda J, Inoue H:
    "iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility"
    FEBS open bio, DOI: 10.1002/2211-5463.13153, (2021)
  • 9. Imamura K, Yada Y, Izumi Y, Morita M, Kawata A, Arisato T, Nagahashi A, Enami T, Tsukita K, Kawakami H, Nakagawa M, Takahashi R, Inoue H:
    "Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells"
    Annals of Neurology, 89(6):1226-1233, DOI:10.1002/ana.26047, (2021)
  • 10. Suzuki H, Egawa N, Kondo T, Imamura K, Enami T, Tsukita K, Suga M, Shibukawa R, Okanishi Y, Uchiyama T, Inoue H:
    "Generation of a human induced pluripotent stem cell line derived from a Parkinson’s disease patient carrying SNCA duplication"
    Stem Cell Research, 45, doi.10.1016/j.scr.2020.101828, (2020)


  • Haruhisa Inoue, Yukio Nakamura (Editors):
    "Medical Applications of iPS Cells - Inovation in Medical Sciences" Springer, (2019)

Related Links

Lab Members

Principal investigator

Haruhisa Inoue
Team Leader

Core members

Mika Suga
Research & Development Scientist
Risako Nakai
Postdoctoral Researcher
Ran Shibukawa
Technical Staff II
Yukako Sagara
Technical Staff II
Takeshi Niki
Technical Staff II

Contact Information

Laboratory Wing 7F, Keihanna Plaza (Keihanna Science City)
1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan
Email: Inoue-brc [at] ml.riken.jp