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RIKEN BioResource Research Center iPSC-based Drug Discovery and Development Team

Team Leader: Haruhisa Inoue (M.D., Ph.D.)

Research Summary

Haruhisa  Inoue(M.D., Ph.D.)

At RIKEN BRC, disease-specific iPS cells established from patients with various diseases are provided as bioresources. The disease-specific iPS cells are used for drug discovery and development.

Three missions of the team are as follows.

  • Using iPS cells of RIKEN BRC to develop infrastructure technology for drug discovery and development
  • Innovating the technology that will open an avenue for practical and general uses
  • Bridging disease-specific iPS cells and academia / industry in the field of translational research

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology

Keywords

  • Disease modeling
  • Drug discovery and development
  • Disease-specific iPS cells

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. *Suong D, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, Inoue H.:
    "Induction of inverted morphology in brain organoids by vertical-mixing bioreactors"
    Communication Biology, DOI: 10.1038/s42003-021-02719-5 (2021)
  • 2. *Ghee Wan Tan, Kondo T, Imamura K, Suga M, Enami T, Nagahashi A, Tsukita K, Inoue I, Kawaguchi J, Shu T, Inoue H.:
    "Simple derivation of skeletal muscle from human pluripotent stem cells using temperature-sensitive Sendai virus vector"
    Journal of Cellular and Molecular Medicine, DOI: 10.1111/jcmm.16899 (2021)
  • 3. Yada Y, Suga M, Shibukawa R, Sagara Y, Okanishi Y, Enami T, Tsukita K, Kondo T, Imamura K, Sugihara G, Murai T, Inoue H.:
    "Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins"
    Stem Cell Research, 55: 102504, DOI: 10.1016/j.scr.2021.102504 (2021)
  • 4. Yada Y, Kondo T, Suga M, Tsukita K, Enami T, Shibukawa R, Sagara Y, Okanishi Y, Imamura K, Kihara T, Inoue H.:
    "Human induced pluripotent stem cells generated from a patient with idiopathic basal ganglia calcification"
    Stem Cell Research,53;102274, DOI: 10.1016/j.scr.2021.102274 (2021)
  • 5. Imamura K, Sakurai Y, Enami T, Shibukawa R, Nishi Y, Ohta A, Shu T, Kawaguchi J, Okada S, Hoenen T, Yasuda J, Inoue H.:
    "iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility"
    FEBS open bio, DOI: 10.1002/2211-5463.13153, (2021)
  • 6. Imamura K, Yada Y, Izumi Y, Morita M, Kawata A, Arisato T, Nagahashi A, Enami T, Tsukita K, Kawakami H, Nakagawa M, Takahashi R, Inoue H.:
    "Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells"
    Annals of Neurology, 89(6):1226-1233, DOI:10.1002/ana.26047, (2021)
  • 7. Suzuki H, Egawa N, Kondo T, Imamura K, Enami T, Tsukita K, Suga M, Shibukawa R, Okanishi Y, Uchiyama T, Inoue H.:
    "Generation of a human induced pluripotent stem cell line derived from a Parkinson’s disease patient carrying SNCA duplication"
    Stem Cell Research, 45, doi.10.1016/j.scr.2020.101828, (2020)
  • 8. Kamata K, Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Yasukawa T, Usui H, Muguruma K, Tsujikawa A, Inoue H.:
    "Generation of a human induced pluripotent stem cell line, BRCi005-A, derived from a Best disease patient with BEST1 mutations"
    Stem Cell Research, 45, doi:10.1016/j.scr.2020.101782, (2020)
  • 9. Kamata K, Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Yasukawa T, Usui H, Muguruma K, Tsujikawa A, Inoue H.:
    "Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration"
    Stem Cell Research, 45, doi.10.1016/j.scr.2020.101787, (2020)
  • 10. Suga M, Kondo T, Inoue H.:
    "Modeling neurological disorders with human pluripotent stem cell-dervied astrocytes."
    International Journal of Molecular Sciences, doi: org/10.3390/ijms20163862, (2019)

Publications

  • Haruhisa Inoue, Yukio Nakamura (Editors):
    "Medical Applications of iPS Cells - Inovation in Medical Sciences" Springer, (2019)

Related Links

Lab Members

Principal investigator

Haruhisa Inoue
Team Leader

Core members

Mika Suga
Research & Development Scientist
Ran Shibukawa
Technical Staff II
Yukako Sagara
Technical Staff II
Hidefumi Suzuki
Junior Research Associate

Contact Information

Laboratory Wing 7F, Keihanna Plaza (Keihanna Science City)
1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan
Email: Inoue-brc [at] ml.riken.jp

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