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RIKEN BioResource Research Center iPSC-based Drug Discovery and Development Team

Team Leader: Haruhisa Inoue (M.D., Ph.D.)

Research Summary

Haruhisa  Inoue(M.D., Ph.D.)

At RIKEN BRC, disease-specific iPS cells established from patients with various diseases are provided as bioresources. The disease-specific iPS cells are used for drug discovery and development.

Three missions of the team are as follows.

  • Using iPS cells of RIKEN BRC to develop infrastructure technology for drug discovery and development
  • Innovating the technology that will open an avenue for practical and general uses
  • Bridging disease-specific iPS cells and academia / industry in the field of translational research

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology

Keywords

  • Disease modeling
  • Drug discovery and development
  • Disease-specific iPS cells

Selected Publications

  • 1. Katagami Y, Kondo T, Suga M, Yada Y, Imamura K, Shibukawa R, Sagara Y, Okanishi Y, Tsukita K, Hirayama K, Era T, Inoue H.:
    "Generation of a human induced pluripotent stem cell line, BRCi009-A, derived from a patient with glycogen storage disease type 1a"
    Stem Cell Research, DOI: 10.1016/j.scr.2020.102095, (2020)
  • 2. Suzuki H, Egawa N, Kondo T, Imamura K, Enami T, Tsukita K, Suga M, Shibukawa R, Okanishi Y, Uchiyama T, Inoue H.:
    "Generation of a human induced pluripotent stem cell line derived from a Parkinson’s disease patient carrying SNCA duplication"
    Stem Cell Research, 45, doi.10.1016/j.scr.2020.101828, (2020)
  • 3. Kamata K, Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Yasukawa T, Usui H, Muguruma K, Tsujikawa A, Inoue H.:
    "Generation of a human induced pluripotent stem cell line, BRCi005-A, derived from a Best disease patient with BEST1 mutations"
    Stem Cell Research, 45, doi:10.1016/j.scr.2020.101782, (2020)
  • 4. Kamata K, Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Yasukawa T, Usui H, Muguruma K, Tsujikawa A, Inoue H.:
    "Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration"
    Stem Cell Research, 45, doi.10.1016/j.scr.2020.101787, (2020)
  • 5. Yamamoto Y, Kojima K, Taura D, Sone M, Washida K, Egawa N, Kondo T, Minakawa E, Tsukita K, Enami T, Tomimoto H, Mizuno T, Kalaria N R, Inagaki N, Takahashi R, Shiba Harada M, Ihara M, Inoue H.:
    "Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease"
    Mol Brain, 13(1):38, doi:10.1186/s13041-020-00573-w, (2020)
  • 6. Egawa N, Chung KK, Takahashi R, Lo EH, Arai K, Inoue H.:
    "Brief review: Can modulating DNA methylation state help the clinical application of oligodendrocyte precursor cells as a source of stem cell therapy?"
    Brain Research, DOI: 10.1016/j.brainres. 2019.146386, (2019)
  • 7. Suga M, Kondo T, Inoue H.:
    "Modeling neurological disorders with human pluripotent stem cell-dervied astrocytes."
    International Journal of Molecular Sciences, doi: org/10.3390/ijms20163862, (2019)
  • 8. Yasumoto T, Takamura Y, Tsuji M, Watanabe-Nakayama T, Imamura K, Inoue H, Nakamura S, Inoue T, Kimura A, Yano S, Nishijo H, Kiuchi Y, David B. Teplow, and Ono K.:
    "High molecular weight amyloid b1-42 oligomers induce neurotoxicity via plasma membrane damage."
    THE FASEB JOURNAL, doi: 10.1096/fj.201900604R (2019)
  • 9. Sekine S, Kaneko M, Tanaka M, Ninomiya Y, Kurita H, Inden M, Yamada M, Hayashi Y, Inuzuka T, Mitsui J, Ishiura H, Iwata A, Fujigasaki H, Tamaki H, Tamaki R, Kito S, Taguchi Y, Tanaka K, Atsuta N, Sobue G, Kondo T, Inoue H, Tsuji S, Hozumi I.:
    "Functional evaluation of PDGFB-variants in idiopathic basal ganglia calcification, using patient-derived iPS cells."
    Scientific Reports doi: 10.1038/s41598-019-42115-y, (2019)
  • 10. Suga M, Kondo T, Imamura K, Shibukawa R, Okanishia Y, Sagara Y, Tsukita K, Enami T, Furujo M, Saijo K, Nakamura Y, Osawa M, Saito MK, Yamanaka S, Inoue H.:
    "Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I. “
    Stem Cell Research, 101406, doi:10.1016/j.scr.2019.101406, (2019)

Publications

  • Haruhisa Inoue, Yukio Nakamura (Editors):
    "Medical Applications of iPS Cells - Inovation in Medical Sciences" Springer, (2019)

Related Links

Lab Members

Principal investigator

Haruhisa Inoue
Team Leader

Core members

Mika Suga
Research & Development Scientist
Yuichiro Yada
Postdoctoral Researcher
Ran Shibukawa
Technical Staff II
Yukako Sagara
Technical Staff II
Yasue Okanishi
Technical Staff II

Contact Information

Laboratory Wing 7F, Keihanna Plaza (Keihanna Science City)
1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan
Email: Inoue-brc [at] ml.riken.jp

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