Research Summary

Selected Publications

• 1. Kulathunga, K., Wakimoto, A., Hiraishi, Y., Yadav, MK., Gentleman, K., Warabi, E., Sakasai, T., Miwa, Y., Mizuno, S., Takahashi, S., Hamada, M.:
  "Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility."
  SCIENTIFIC REPORTS 11:21827 doi: 10.1038/s41598-021-00501-5 (2021).
• 2. Mizuno-Iijima, S., Ayabe, S., Kato, K., Matoba, S., Ikeda, Y., Dinh, TTH., Le, HT., Suzuki, H., Nakashima, K., Hasegawa, Y., Hamada, Y., Tanimoto, Y., Daitoku, Y., Iki, N., Ishida, M., Ibrahim, EAE., Nakashiba, T., Hamada, M., Murata, K., Miwa, Y., Okada-Iwabu, M., Iwabu, M., Yagami, K., Ogura, A., Obata, Y., Takahashi, S., Mizuno, S., Yoshiki, A., Sugiyama, F.:
  "Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes."
  Methods S1046-2023(19)30328-7 doi:10.1016/j.ymeth.2020.04.007 (2020).
• 3. Ayabe, S., Nakashima, K., Yoshiki, A.:
  "Off- and on-target effects of genome editing in mouse embryos."
  J Reprod Dev 65 1-5 (2019).
• 4. Kurihara, C., Nakade, K., Pan, J., Huang, J., Wasylyk, B., Obata, Y.:
  "An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes"
  Biotechnol Rep Vol.12 26-32 (2016).
• 5. Kohara, K., Pignatelli, M., Rivest, AJ., Jung, HY., Kitamura, T., Suh, J., Frank, D., Kajikawa, K., Mise, N., Obata, Y., Wickersham, IR., Tonegawa, S.:
  "Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits."
  Nat Neurosci Vol. 17 269-279 (2014).
• 6. Hasegawa, N., Abei, M., Yokoyama, K., Fukuda, K., Seo, E., Kawashima, R., Nakano, Y., Yamada, T., Nakade, K., Hamada, H., Obata, Y., and Hyodo, I.:
  "Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters."
  Int. J. Cancer, 133, 1479-1488 (2013).
• 7. Inagawa, K., Miyamoto, K., Yamakawa, H., Muraoka, N., Sadahiro, T., Umei, T., Wada, R., Katsumata, Y., Kaneda, R., Nakade, K., Kurihara, C., Obata, Y., Miyake, K., Fukuda, K., and Ieda, M.:
  "Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5."
  Circ. Res., 111, 1147-1156 (2012).
• 8. Masuya, H., Makita, Y., Kobayashi, N., Nishikata, K., Yoshida, Y., Mochizuki, Y., Doi, K., Takatsuki, T., Waki, K., Tanaka, N., Ishii, M., Matsushima, A., Takahashi, S., Hijikata, A., Kozaki, K., Furuichi, T., Kawaji, H., Wakana, S., Nakamura, Y., Yoshiki, A., Murata, T., Fukami, K., Sujatha, M. S., Ohara, O., Hayashizaki, Y., Obata, Y., Toyoda, T.:
  "The RIKEN integrated database of mammals."
  Nuc. Acids Res., 39, D861-D870 (2011).
• 9. Pan, J., Nakade, K., Huang, Y-C., Zhu, Z-W., Masuzaki, S., Hasegawa, H., Murata, T., Yoshiki, A., Yamaguchi, N., Lee, C-H., Yang, W-C., Tsai, E-M., Obata, Y., and Yokoyama, K.:
  "Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2."
  Oncogene, 29, 6245-6256 (2010).
• 10. Nakade, K., Pan, J., Yamasaki, T., Murata, T., Wasylyk, B. and Yokoyama, K.:
  "JDP2 (Jun dimerization protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescence."
  J. Biol. Chem., 284, 10808-10817 (2009).

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