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RIKEN BioResource Research Center (BRC®) Mouse Phenotype Analysis Division

Director: Masaru Tamura (Ph.D.)

Research Summary

Masaru  Tamura(Ph.D.)

The Mouse Phenotype Analysis Division develops a systematic and comprehensive phenotyping platform consisting of more than 700 test items, based on the knowledge of pathogenesis of human diseases. Using this system, we perform more comprehensive and profound phenotyping of mouse mutants, which are and will be deposited to RIKEN BRC. We also develop Standard Operating Procedures (SOPs) of mouse phenotyping and exchange this information with attending the IMPC (International Mouse Phenotyping Consortium) projects for analyzing international public knockout mouse resources, and thereby we will contribute to international efforts for standardization of mouse phenotype data.

Main Research Fields

  • Biology

Related Research Fields

  • Bioresource
  • Disease model mouse
  • Experimental animal technology

Keywords

  • Mouse phenotype analysis
  • Behavioral analysis
  • Functional gene analysis
  • Development of phenotyping technology

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Watanabe C. Shibuya H. Ichiyama Y. Okamura E. Tsukiyama-Fujii S. Tsukiyama T. MatsumotoS. Matsushita J. Azami T. Kubota Y. Ohji M. Sugiyama F. Takahashi S. Mizuno S. Tamura M. Mizutani K. and Ema M.:
    "Essential roles of Exocyst complex component 3-like 2 on cardiovascular development in mice."
    Life 12, 1730 (2022).
  • 2. Birling MC. Yoshiki A. Adams D. Ayabe S. Beaudet AL. Bottomley J. Bradley A. Brown SDM. Bürger A. Bushell W. Chiani F. Christou S. Codner GF. DeMayo FJ. Dickinson ME. Doe B. Donahue LR. Fray MD. Gambadoro A. Gertsenstein M. Gomez-Segura A. Goodwin LO. Heaney JD. Hérault Y. Hrabé de Angelis M. Justice MJ. King RE. Kühn R. Lee H. Lee YJ. Lloyd KCK. Lorenzo I. Mallon AM. McKerlie C. Meehan TF. Nutter LMJ. Oh GT. Pavlovic G. Ramirez-Solis R. Rosen B. Ryder EJ. Santos LA. Schick J. Seavitt JR. Seong JK. Skarnes WC. Steel K. Tamura M. Tocchini-Valentini GP. Wang CKL. Wardle-jones H. Wattenhofer-donze M. Wells S. Willis BJ. Wood JA. Wurst W. The International Mouse Phenotyping Consortium. Teboul L. and Murray SA.:
    "A resource of targeted mutant mouse lines for 5,061 genes."
    Nature Genetics 53, 416–419 (2021).
  • 3. Matsumura K. Seiriki K. Okada S. Nagase M. Ayabe S. Yamada I. Furuse T. Shibuya H. Yasuda Y. Yamamori H. Fujimoto M. Nagayasu K. Yamamoto K. Kitagawa K. Miura H. Gotoda-Nishimura N. Igarashi H. Hayashida M. Baba M. Kondo M. Hasebe S. Ueshima K. Kasai A. Ago Y. Hayata-Takano A. Shintani N. Iguchi T. Sato M. Yamaguchi M. Tamura M. Wakana S. Yoshiki A. Watabe A. Okano H. Takuma K. Hashimoto R. Hashimoto H. and Nakazawa T.:
    "Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes."
    Nature Communications 11, 859 (2020)
  • 4. Haselimashhadi H. Mason J. Munoz-Fuentes V. Lopez-Gomez F. Babalola K. Acar E. Kuma V. White J. Flenniken A. King R. Straiton E. Seavitt JR. Gaspero A. Garza A. Christiansen A. Hsu CW. Reynolds C. Lanza D. Lorenzo I. Green J. Gallegos J. Bohat R. Samaco R. Veeraragavan S. Kim JK. Miller G. Fuchs H. Garrett L. Becker L. Kang YK. Clary D. Soo Y.,Tamura M. Tanaka N. Kyoung DS. Bezginov A. Bou About G. Champy MF. Vasseur L. Leblanc S. Meziane H. Selloum M. Reilly P. Spielmann N. Maier H. Gailus-Durner V. Sorg T. Masuya H. Obata Y. Heaney J. Dickinson M. Wurst W. Tocchini-Valentini G. Lloyd KCK. McKerlie C. Seong JK. Hérault Y. Hrabé de Angelis M. Brown S. Smedley D. Flicek P. Mallon AM. Parkinson H. and Meehan T.:
    "Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data."
    Bioinformatics, btz744 (2019).
  • 5. Kishimoto K. Tamura M. Nishita M. Minami Y. Yamaoka A. Abe T. Shigeta M. and Morimoto M.:
    "Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus."
    Nature Communications 9, 2816 (2018).
  • 6. Meehan, TF. et al. and The International Mouse Phenotyping Consortium (IMPC).:
    "Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium."
    Nature Genetics 49, 1231-1238 (2017).
  • 7. Dickinson ME. Flenniken AM. Ji X. Teboul L. Wong MD. White JK. Meehan TF. Weninger WJ. Westerberg H. Adissu H. Baker CN. Bower L. Brown JM. Caddle LB. Chiani F. Clary D. Cleak J. Daly MJ. Denegre JM. Doe B. Edie SM. Fuchs H. Gailus-Durner V. Galli A. Gambadaro A. Gallegos J. Guo S. Horner NR. Hsu Cw. Johnson SJ. Kalaga S. Keith LC. Lanoue L. Lawson TN. Lek M. Mark M. Marschall S. Mason J. McElwee ML. Newbigging S. Nutter LMJ. Peterson KA. Ramirez-Solis R. Rowland DJ. Ryder E. Samocha KE. Seavitt JR. Selloum M. Szoke-Kovacs Z. Tamura M. Trainor AG. Tudose I. Wakana S. Warren J. Wendling O. West DB. Wong L. Yoshiki A. The International Mouse Phenotyping Consortium, MacArthur DG. Tocchini-Valentini GP. Gao X. Flicek P. Justice M. Parkinson HE. Moore M. Wells S. Braun RE. Svenson K. Hrabé de Angelis M. Herault Y. Mohun T. Mallon AM. Henkelman RM. Brown SD. Adams D. Lloyd KCK. McKerlie C. Beaudet AL. Bucan M. and Murray SA.:
    "High-throughput discovery of novel developmental phenotypes."
    Nature 537, 508-514 (2016).
  • 8. Tamura M. and Shiroishi T.:
    "GSDM family genes meet autophagy."
    Biochemical Journal 469, e5-e7 (2015).
  • 9. Tamura M. Amano T. and Shiroishi T.:
    "The Hand2 gene dosage effect in developmental defects and human congenital disorders."
    Current Topics in Developmental Biology110, 129-152 (2014).
  • 10. *Tamura M. Hosoya M. Fujita M. Iida T. Amano T. Maeno A. Kataoka T. Otsuka T. Tanaka S, Tomizawa S. and Shiroishi T.:
    "Over-dosage of Hand2 causes limb and heart defects in human chromosomal disorder, partial trisomy distal 4q."
    Human Molecular Genetics 22, 2471-2481 (2013).

Recent Research Results

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Lab Members

Principal investigator

Masaru Tamura
Director

Core members

Tamio Furuse
Senior Scientist
Hirotoshi Shibuya
Research & Development Scientist
Ikuo Miura
Technical Scientist
Ikuko Yamada
Technical Scientist
Ryo Kominami
Research Consultant
Tomoko Kushida
Technical Staff II
Kyoko Ikeda
Technical Staff II
Ai Ozaki
Technical Staff II
Akiko Shinogi
Technical Staff II
Yasuyo Kozawa
Technical Staff II
Mao Ozaki
Technical Staff II
Shundan Jin
Technical Staff II
Tomona Oikawa
Technical Staff II

Contact Information

3-1-1 Koyadai
Tsukuba, Ibaraki
305-0074 Japan
Email: masaru.tamura [at] riken.jp

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