1. Home
  2. Research
  3. Centers & Labs
  4. RIKEN Baton Zone Program

RIKEN Baton Zone Program Cell and Gene Therapy in Ophthalmology Laboratory

Team Leader: Seiji Hori (Ph.D.)
Deputy Team Leader: Hiroshi Kiyonari (Ph.D.)

Research Summary

Team Leader: Seiji Hori Deputy Team Leader: Hiroshi Kiyonari

Vision Care Inc. has been developing regenerative medicine and gene therapy using pluripotent stem cells for patients who have lost visual function due to intractable retinal diseases.

In addition, the RIKEN Center for Biosystems Dynamics Research (BDR) has developed a large number of genetically engineered animals and new experimental animal models to analyze the pathophysiology of diseases and the efficacy of treatments.

Based on these valuable results, we aim to further optimize the technology and provide comprehensive treatment for gene therapy and regenerative medicine by advancing non-clinical animal studies specifically for retinal degenerative diseases.

[Integrated Collaborative Research with: Vision Care Inc.]

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology
  • Ophthalmology
  • Gene therapy
  • Regenerative medicine

Keywords

  • Regenerative medicine
  • Pluripotent stem cell
  • Gene therapy
  • Nonclinical study
  • Retinal degeneration

Selected Publications

  • 1. Michiko Mandai, Akira Watanabe, Yasuo Kurimoto, Yasuhiko Hirami, Chikako Morinaga, Takashi Daimon, Masashi Fujihara, Hiroshi Akimaru, Noriko Sakai, Yumiko Shibata, Motoki Terada, Yui Nomiya, Shigeki Tanishima, Masahiro Nakamura, Hiroyuki Kamao, Sunao Sugita, Akishi Onishi, Tomoko Ito, Kanako Fujita, Shin Kawamata, Masahiro J Go, Chikara Shinohara, Ken-Ichiro Hata, Masanori Sawada, Midori Yamamoto, Sachiko Ohta, Yasuo Ohara, Kenichi Yoshida, Junko Kuwahara, Yuko Kitano, Naoki Amano, Masafumi Umekage, Fumiyo Kitaoka, Azusa Tanaka, Chihiro Okada, Naoko Takasu, Seishi Ogawa, Shinya Yamanaka, Masayo Takahashi.
    "Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration"
    N Engl J Med. 2017 Mar 16;376(11):1038-1046. doi: 10.1056/NEJMoa1608368.
  • 2. Kiyonari H, Kaneko M, Abe T, Shiraishi A, Yoshimi R, Inoue KI, Furuta Y.
    "Targeted gene disruption in a marsupial, Monodelphis domestica, by CRISPR/Cas9 genome editing"
    Curr Biol. 2021 Sep 13;31(17):3956-3963.e4. doi: 10.1016/j.cub.2021.06.056. Epub 2021 Jul 21.

Related Links

Lab Members

Principal investigator

Seiji Hori
Team Leader

Core members

Hiroshi Kiyonari
Deputy Team Leader
Takaya Abe
Research Scientist
Mari Kaneko
Technical Staff I
Riko Yoshimi
Technical Staff II
Aki Shiraishi
Technical Staff II
Masayo Takahashi
Visiting Scientist
Hashimita Sanyal
Visiting Scientist
Yoko Futatsugi
Visiting Scientist
Tomohiro Masuda
Visiting Scientist
Kohei Homma
Visiting Scientist
Akishi Onishi
Visiting Scientist
Kazushi Yasuda
Visiting Scientist
Takesi Matsuyama Hoyos
Visiting Scientist
Tadao Maeda
Visiting Scientist
Mikiya Watanabe
Visiting Technician
Yoko Ohigashi
Visiting Technician
Tomoko Katayama
Visiting Technician
Toshika Senba
Visiting Technician
Takayuki Yamada
Visiting Technician
Naoko Hayashi
Visiting Technician
Junki Sho
Visiting Technician
Mitsuhiro Nishida
Visiting Technician
Hironobu Shuto
Visiting Technician
Satoshi Shirae
Visiting Technician
Masakazu Hiraoka
Visiting Technician
Atsuta Ozaki
Visiting Technician
Daiki Sakai
Visiting Technician
Kyoko Iseki
Visiting Technician
Yasuaki Iwama
Student Trainee
Satomi Tanaka
Administrative Part-time Worker II

Contact Information

RIKEN Center for Biosystems Dynamics Research
2-2-3 Minatojima Minami-cho, Chuo-ku,
Kobe, Hyogo 650-0047, Japan
Email: ks-rinc [at] ml.riken.jp

Top