Research Summary

Selected Publications

• 1. Iwama Y, Nomaru H, Masuda T, Kawamura Y, Matsumura M, Murata Y, Teranishi K, Nishida K, Ota S, Mandai M, Takahashi M.
  "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies."
  Stem Cell Reports. 2024 Feb 13;19(2):254-269.
• 2. Hirami Y, Mandai M, Sugita S, Maeda A, Maeda T, Yamamoto M, Uyama H, Yokota S, Fujihara M, Igeta M, Daimon T, Fujita K, Ito T, Shibatani N, Morinaga C, Hayama T, Nakamura A, Ueyama K, Ono K, Ohara H, Fujiwara M, Yamasaki Y, Watari K, Bando K, Kawabe K, Ikeda A, Kimura T, Kuwahara K, Takahashi M, Kurimoto Y.
  "Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa.”
  Cell Stem Cell. 2023 Dec 7;30(12) :1585-1596
• 3. Terada M, Kogawa Y, Shibata Y, Kitagawa M, Kato S, Iida T, Yorimitsu T, Kato A, Matsukuma K, Maeda T, Takahashi M, Kanda GN.
  "Robotic cell processing facility for clinical research of retinal cell therapy."
  SLAS Technology 2023 Dec; 28(6): 449-459
• 4. Akishi Onishi, Yuji Tsunekawa, Michiko Mandai, Aiko Ishimaru, Yoko Ohigashi, Junki Sho, Kazushi Yasuda, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, Fumio Matsuzaki, Masayo Takahashi
  "Efficient workflow for validating homology-independent targeted integration-mediated gene insertion in rod photoreceptor cells to treat dominant-negative mutations causing retinitis pigmentosa"
  bioRxiv 2023.11.08.566127
• 5. Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y, Terada M, Nomiya Y, Tanishima S, Nakamura M, Kamao H, Sugita S, Onishi A, Ito T, Fujita K, Kawamata S, Go MJ, Shinohara C, Hata KI, Sawada M, Yamamoto M, Ohta S, Ohara Y, Yoshida K, Kuwahara J, Kitano Y, Amano N, Umekage M, Kitaoka F, Tanaka A, Okada C, Takasu N, Ogawa S, Yamanaka S, Takahashi M.
  "Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration."
  N Engl J Med. 2017 Mar 16;376(11):1038-1046.
• 6. Kiyonari H, Kaneko M, Abe T, Shiraishi A, Yoshimi R, Inoue KI, Furuta Y.
  "Targeted gene disruption in a marsupial, Monodelphis domestica, by CRISPR/Cas9 genome editing."
  Curr Biol. 2021 Sep 13;31(17):3956-3963.e4.
• 7. Nishiyama C, Saito Y, Sakaguchi A, Kaneko M, Kiyonari H, Xu Y, Arima Y, Uosaki H, Kimura W.
  "Prolonged Myocardial Regenerative Capacity in Neonatal Opossum."
  Circulation. 2022 Jul 12;146(2): 125-139.

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