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Chief Scientist Laboratories Nonequilibrium Physics of Living Matter Laboratory

Chief Scientist: Kyogo Kawaguchi (Ph.D.)

Research Summary

Kyogo Kawaguchi

We are a biophysics research group exploring phase transitions, morphogenesis, evolution, and chromatin physics through both experimental and theoretical approaches. We integrate physics, machine learning, and a range of experimental techniques, from cell-based assays to single-molecule observation, to address diverse biological questions from an original viewpoint.

Main Research Fields

  • Mathematical & Physical Sciences

Related Research Fields

  • Complex Systems
  • Biological Sciences
  • Biology
  • Biophysics, chemical physics and soft matter physics-related
  • Mathematical physics and fundamental theory of condensed matter physics-related

Keywords

  • Nonequilibrium
  • Collective cell dynamics
  • Morphological evolution
  • Chromatin

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Cerbus, R.T., Hiratani, I., and Kawaguchi, K.:
    "Homeotic and non-homeotic patterns in the tetrapod vertebral formula"
    PNAS 121, 2411421121 (2024).
  • 2. Adachi, K., and Kawaguchi, K.:
    "Predicting heteropolymer interactions: Demixing and hypermixing of disordered protein sequences"
    Phys Rev X 14, 031011 (2024).
  • 3. Lubana, E.S., Kawaguchi, K., Dick, R.P., and Tanaka, H.:
    "A percolation model of emergence: Analyzing transformers trained on a formal language"
    Accepted at ICML (2025).
  • 4. Fukai, Y., and Kawaguchi, K.:
    "LapTrack: Linear assignment particle tracking with tunable metrics"
    Bioinformatics, 39, btac799 (2022).
  • 5. Yamamoto, T., Cockburn, K., Greco, V., and Kawaguchi, K.:
    "Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks"
    PLOS Comp Biol 18, e1010477 (2022).
  • 6. Adachi, K., Takasan, K., and Kawaguchi, K.:
    "Activity-induced phase transition in a quantum many-body system"
    Phys Rev Research 4, 013194 (2022).
  • 7. Mesa, K.R., Kawaguchi, K., Cockburn, K., Gonzalez, D., Boucher, J., Xin, T., Klein, A.M., and Greco, V.:
    "Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation"
    Cell Stem Cell 23, 677 (2018).
  • 8. *Kawaguchi, K., Kageyama, R., and Sano, M.:
    "Topological defects control collective dynamics in neural progenitor cell cultures"
    Nature 545, 327–331 (2017).

Recent Research Results

Related Links

Lab Members

Principal investigator

Kyogo Kawaguchi
Chief Scientist

Contact Information

2-2-3, Minatojima-minamimachi,
Chuo-ku, Hyogo
650-0047, Japan
Email: kyogo.kawaguchi@riken.jp

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