1. Home
  2. Research
  3. Centers & Labs
  4. RIKEN Center for Sustainable Resource Science

RIKEN Center for Sustainable Resource Science Catalysis and Integrated Research Group

Group Director: Mikiko Sodeoka (D.Phar.)

Research Summary

Mikiko  Sodeoka(D.Phar.)

Our group focuses on the development of new transition metal-catalyzed reactions and exploitation of functions of the reaction products, and on conducting integrated research of plant science and chemistry with emphasis on sustainable resource science. In particular, we aim at developing methodologies for manipulation and/or modulation of structures and functions of organic molecules by catalytic oxidation reactions utilizing molecular oxygen, which will contribute to the effective utilization of carbon- and metal-based resources. In addition, investigation on the transformations of readily accessible natural organic molecules into valuable materials based on fine synthetic organic chemistry, as well as on the effective utilization of materials synthesized by newly developed reactions or from secondary metabolites of plants are of interest. In particular, we are studying various aspects of secondary metabolites of plants, whose effects on plants and animals have not been well clarified. Furthermore, this group will also contribute to enhance the collaboration between plant/microbiology research and chemical research activities inside CSRS.

Main Research Fields

  • Chemistry

Related Research Fields

  • Biological Sciences
  • Medicine, Dentistry & Pharmacy


  • bioactive molecule
  • catalytic reaction
  • fluorine-containing molecule

Selected Publications

  • 1. Ezawa, T., Sohtome, Y., Hashizume, D., Adachi, M., Akakabe, M., Koshino, H., and Sodeoka, M.:
    "Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates"
    J. Am. Chem. Soc. 143, 9094-9104 (2021).
  • 2. Sugawara, M., Ohnishi, R., Ezawa, T., Akakabe, M., Sawamura, M., Hojo, D., Hashizume, D., Sohtome,Y., and Sodeoka, M.:
    "Regiodivergent Oxidative Cross-Coupling of Catechols with Persistent tert-Carbon Radicals"
    ACS Catalysis, 10, 12770-12782 (2020)
  • 3. Kawamura, S., and Sodeoka, M.:
    "Fluoroalkylation Methods for Synthesizing Versatile Building Blocks"
    Bull. Chem. Soc. Jpn. 92, 1245-1262 (2019).
  • 4. Valverde, E., Kawamura, S., Sekine, D., and Sodeoka, M.:
    "Metal-free Alkene Oxy- and Amino-perfluoroalkylations via Carbocation Formation by Using Perfluoro Acid Anhydrides: Unique Reactivity Between Styrenes and Perfluoro Diacyl Peroxides"
    Chem. Sci. 8, 7115-7121 (2018).
  • 5. Bartlett, S. L., Sohtome, Y., Hashizume, D., White P. S., Sawamura, M., Johnson, J. S., and Sodeoka, M.:
    "Catalytic Enantioselective [3+2] Cyclization of α-Keto Ester Enolates and Nitrile Oxides
    J. Am. Chem. Soc. 139, 8661-8666 (2017).
  • 6. Sohtome, Y., Nakamura, G., Muranaka, A., Hashizume, D., Lectard, S., Tsuchimoto, T., Uchiyama, M., and Sodeoka, M.:
    "Naked d-Orbital in a Centrochiral Ni(II) Complex as a Catalyst for Asymmetric [3+2] Cycloaddition"
    Nature Comm. 8, 14875 (2017).
  • 7. Ueda, M., Egoshi, S., Dodo, K., Ishimaru, Y., Yamakoshi, H., Nakano, T., Takaoka, Y., Tsukiji, S., Sodeoka, M.:
    "Noncannonical Function of a Small-Molecular Virulence Factor Coronatine against Plant Immunity: An In Vivo Raman Imaging Approach"
    ACS Cent. Sci. 3, 462-472 (2017).
  • 8. Kawamura, S., and Sodeoka, M.:
    "Perfluoroalkylation of Unactivated Alkenes with Acid Anhydrides as the Perfluoroalkyl Source"
    Angew. Chem. Int. Ed. 55, 8740-8743 (2016).
  • 9. Kawamura, S., Egami. H., and Sodeoka, M.:
    "Aminotrifluoromethylation of Olefins via Cyclic Amine Formation: Its Mechanistic Study and Application to Synthesis of Trifluoromethylated Pyrrolidines"
    J. Am. Chem. Soc. 137, 4865-4873 (2015).
  • 10. Egami, H., and Sodeoka, M.:
    "Recent Progress on Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups"
    Angew. Chem. Int. Ed. 53, 2894-8308 (2014).

Recent Research Results

Related Links

Lab Members

Principal investigator

Mikiko Sodeoka
Group Director

Core members

Kosuke Dodo
Senior Research Scientist
Yoshihiro Sohtome
Senior Research Scientist
Shintaro Kawamura
Senior Scientist
Shusuke Egoshi
Research Scientist
Takuma Tagami
Special Postdoctoral Researcher
Kota Koike
Postdoctoral Researcher
Yanzong Lyu
Postdoctoral Researcher
Satoshi Yoshimoto
Postdoctoral Researcher
Mai Akakabe
Technical Staff I
Takumi Kariya
Technical Staff I
Subrata Mukherjee
Visiting Researcher
Izumi Saito
Xiuling Wang
Research Part-time Worker II
Ayako Kubota
Temporary Staffing

Contact Information

S601 Chemistry and Materials Physics Building
2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: sodeoka [at] riken.jp