RIKEN Center for Sustainable Resource Science Environmental Metabolic Analysis Research team
Team Leader: Jun Kikuchi (Ph.D.)
Research Summary

Our team intends to develop novel environmental analysis such as by a bird’s-eye view of metabolism caused by ecosystem biodiversity, based on technical advancements of our NMR approaches toward metabolite and biomass mixtures, as well as inorganic elements and microbial ecosystem analyses combined with bioinformatics and chemoinformatics approaches. Namely, we promote both international and industrial collaboration in order to contribute for effective utilization of chemical resources, by analyzing laboratory systems, industrial (agriculture, forestry, and fishery) process, and natural environment (hydrosphere and geosphere, as well as outer space).
Main Research Fields
- Complex Systems
Related Research Fields
- Chemistry
- Agricultural Sciences
- Informatics
- Environmental Science
- Interdisciplinary Science & Engineering
- Mathematical & Physical Sciences
- Biological Sciences
- Life Sciences
- Environmental Analysis & Modeling
- Aquatic Ecosystem
Keywords
- Environmental analysis
- Data science
- Magnetic resonance
- Symbiosis
- Homeostasis
Selected Publications
- 1.
Ito, K., Tsuboi, Y. and Kikuchi, J.*.:
"Spatial molecular-dynamically ordered NMR spectroscopy of intact bodies and heterogeneous systems"
Commun. Chem. (in press). - 2.
Ichihashi, Y.*, Date, Y., Shino, A., Shimizu, T., Shibata, A., Kumaishi, K., Funahashi, F., Wakayama, K., Yamazaki, K., Umezawa, A., Sato, T., Kobayashi, M., Kamimura, M., Kusano, M., Che, F.-S., O’Brien, M., Tanoi, K., Hayashi, M., Nakamura, R., Shirasu, K., Kikuchi, J. and Nihei, N.*
"Multi-omics analysis on an agroecosystem reveals the significant role of organic nitrogen to increase agricultural crop yield"
Proc. Natl. Acad. Sci. USA (in press). - 3.
Mega, R., Abe, F., Kim, J.-S., Tsuboi, Y., Tanaka, K., Kobayashi, H., Sakata, Y., Hanada, K., Tsujimoto, H., Kikuchi, J., Cutler, S. R. and Okamoto, M.*
"Tuning water use efficiency and drought tolerance in wheat using ABA receptors"
Nature Plants 5, 153-159 (2019). - 4.
Ito, K., Obuchi, Y., Chikayama, E., Date, Y. and Kikuchi, J.*
"Exploratory machine-learned theoretical chemical shifts can closely predict metabolic mixture signals"
Chem. Sci. 9, 8213-8220 (2018). - 5.
Kikuchi, J.*, Ito, K. and Date, Y.
"Environmental metabolomics with data science as investigation of ecosystem homeostasis"
Progress in NMR Spectroscopy 104, 56-88 (2018). - 6.
Date, Y.* and Kikuchi, J.*
"Application of a deep neural network to metabolomics studies and its performance in determining important variables"
Anal. Chem. 90, 1805-1810 (2018). - 7.
Oita, A., Oshima, T., Tsuboi, Y., Moriya, S., Date, Y. and Kikuchi, J.*
"Profiling physicochemical and planktonic features from discretely/continuously sampled surface water"
Sci. Total Environ. 636, 12-19 (2018). - 8.
Komatsu, T., Ohishi, R., Shino, A. and Kikuchi, J.*
"Structure and metabolic flow analysis of molecular complexity in 13C-labeled tree by 2D and 3D-NMR"
Angew. Chem. Int. Ed. 55, 6000-6003 (2016). - 9.
Furusawa, Y., Obata, Y., Fukuda, S.*, Endo, T., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M., Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K.* and Ohno, H.
"Commensal microbe-derived butyrate induces colonic regulatory T cells"
Nature 504, 446-450 (2013). - 10.
Fukuda, S., Toh, H., Hase, K., Nakanishi, Y., Oshima, K., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M.* and Ohno, H.*
"Bifidobacteria protect from enteropathogenic infection through production of acetate"
Nature 469, 543-547 (2011).
Recent Research Results
Jun. 17, 2016
Torrefied biomass improves poor soilMar. 28, 2014
Seasonal seaweed highlights chemical diversity
Events
Related Links
Lab Members
Principal investigator
- Jun Kikuchi
- Team Leader
Core members
- Kenichi Akagi
- Research Scientist
- Hideaki Shima
- Research Scientist
- Ayari Takamura
- Special Postdoctoral Researcher
- Kengo Ito
- Postdoctoral Researcher
- Atsushi Kurotani
- Postdoctoral Researcher
- Feifei Wei
- Postdoctoral Researcher
- Daiki Yokoyama
- Postdoctoral Researcher
- Shunji Yamada
- Junior Research Associate
- Yuuri Tsuboi
- Technical Staff I
- kenji Sakata
- Technical Staff I
- Tomoko Matsumoto
- Technical Staff II
- Akiyo Tei
- Technical Staff II
Contact Information
1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan
Tel: +81-(0)45-508-7549
Email: ikenoa [at] riken.jp