Research Summary

Selected Publications

• 1.Ohnuki, S., Ogawa, I., Itto-Nakama, K., Lu, F., Ranjan, A., Kabbage, M., Gebre, AA., Yamashita, M., Li, SC., Yashiroda, Y., Yoshida, S., Usui, T., Piotrowski, JS., Andrews, BJ., Boone, C., Brown, GW., Ralph, J., Ohya, Y.:
  "High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds."
  NPJ Syst. Biol. Appl., 8, 3 (2022).
• 2.Kubo, K., Itto-Nakama, K., Ohnuki, S., Yashiroda, Y., Li, SC., Kimura, H., Kawamura, Y., Shimamoto, Y., Tominaga, KI., Yamanaka, D., Adachi, Y., Takashima, S., Noda, Y., Boone, C., Ohya, Y.:
  "Jerveratrum-type steroidal alkaloids inhibit β-1,6-glucan biosynthesis in fungal cell walls."
  Microbiol. Spectr., 10, e0087321 (2022).
• 3.Fu, C., Zhang, X., Veri, AO., Iyer, KR., Lash, E., Xue, A., Yan, H., Revie, NM., Wong, C., Lin, ZY., Polvi, EJ., Liston, SD., VanderSluis, B., Hou, J., Yashiroda, Y., Gingras, AC., Boone, C., O'Meara, TR., O'Meara, MJ., Noble, S., Robbins, N., Myers, CL., Cowen, LE.:
  "Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets."
  Nat. Commun. 12, 6497 (2021).
• 4.Safizadeh, H., Simpkins, SW., Nelson, J., Li, SC., Piotrowski, JS., Yoshimura, M., Yashiroda, Y., Hirano, H., Osada, H., Yoshida, M., Boone, C., Myers, CL.:
  "Improving measures of chemical structural similarity using machine learning on chemical-genetic interaction."
  J. Chem. Inf. Model., 61, 4156-4172 (2021).
• 5.Persaud, R., Li, SC., Chao, JD., Forestieri, R., Donohue, E., Balgi, AD., Zheng, X., Chao, JT., Yashiroda, Y., Yoshimura, M., Loewen, CJR., Gingras, AC., Boone, C., Av-Gay, Y., Roberge, M., Andersen, RJ.:
  "Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1."
  Cell Chem. Biol., doi: 10.1016/j.chembiol.2021.07.017. (2021).
• 6.Tomita, K., Yashiroda, Y., Matsuo, Y., Piotrowski, JS., Li, SC., Okamoto, R., Yoshimura, M., Kimura, H., Kawamura, Y., Kawamukai, M., Boone, C., Yoshida, M., Nojiri, H., Okada, K.:
  "Genome-wide screening of genes associated with momilactone B sensitivity in the fission yeast Schizosaccharomyces pombe."
  G3 (Bethesda), 11, jkab156 (2021).
• 7.Arita, Y., Kim, G., Li, Z., Friesen, H., Turco, G., Wang, RY., Climie, D., Usaj, M., Hotz, M., Stoops, EH., Baryshnikova, A., Boone, C., Botstein, D., Andrews, BJ., McIsaac, RS.:
  "A genome-scale yeast library with inducible expression of individual genes."
  Mol. Syst. Biol., 17, e10207 (2021).
• 8.Costanzo, M., Hou. J., Messier, V., Nelson, J., Rahman, M., VanderSluis, B., Wang, W., Pons, C., Ross, C., Ušaj, M., San Luis, BJ., Shuteriqi, E., Koch, EN., Aloy, P., Myers, CL., Boone, C., Andrews, B.:
  "Environmental robustness of the global yeast genetic interaction network."
  Science, 372, abf8424 (2021).
• 9.Simpkins, SW., Deshpande, R., Nelson, J., Li, SC., Piotrowski, JS., Ward, HN., Yashiroda, Y., Osada, H., Yoshida, M., Boone, C., Myers, CL.:
  "Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments."
  Nat. Protoc., 14, 415-440 (2019).
• 10.Piotrowski, JS., Li, SC., Deshpande, R., Simpkins, SW., Nelson, J., Yashiroda, Y., Barber, JM., Safizadeh, H., Wilson, E., Okada, H., Gebre, AA., Kubo, K., Torres, NP., LeBlanc, MA., Andrusiak, K., Okamoto, R., Yoshimura, M., van Leeuwen, J., Shirahige, K., Baryshnikova, A., Brown, GW., Hirano, H., Costanzo, M., Andrews, B., Ohya, Y., Osada, H., Yoshida, M., Myers, CL., and Boone, C.:
  "Functional annotation of chemical libraries across diverse biological processes."
  Nat. Chem. Biol., 13, 982–993 (2017).

Recent Research Results

• 

  Oct. 6, 2017
  A smarter way to screen molecular libraries

Related Links

Lab Members

Contact Information