研究概要

主要論文

• 1. Diehl, C., Pinzan, CF., de Castro, PA., Delbaje, E., García Carnero, LC., Sánchez-León, E., Bhalla, K., Kronstad, JW., Kim, D-g., Doering, TL., Alkhazraji, S., Mishra, NN., Ibrahim, AS., Yoshimura, M., Vega Isuhuaylas, LA., Pham, LTK., Yashiroda, Y., Boone, C., Dos Reis, TF., Goldman, GH.:
  "Brilacidin, a novel antifungal agent against Cryptococcus neoformans"
  mBio, 15, e0103124 (2024).
• 2. Iyer, KR., Li, SC., Revie, NM., Lou, JW., Duncan, D., Fallah, S., Sanchez, H., Skulska, I., Ušaj, MM., Safizadeh, H., Larsen, B., Wong, C., Aman, A., Kiyota, T., Yoshimura, M., Kimura, H., Hirano, H., Yoshida, M., Osada, H., Gingras, AC., Andes, DR., Shapiro, RS., Robbins, N., Mazhab-Jafari, MT., Whitesell, L., Yashiroda, Y., Boone, C., Cowen, LE.:
  "Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity"
  Cell Chem. Biol., 30, 795-810 (2023).
• 3. Saeki, N., Yamamoto, C., Eguchi, Y., Sekito, T., Shigenobu, S., Yoshimura, M., Yashiroda, Y., Boone, C., Moriya, H.:
  "Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments"
  PLoS Genetics, 19, e1010732 (2023).
• 4. Forster, DT., Li, SC., Yashiroda, Y., Yoshimura, M., Li, Z., Isuhuaylas, LAV., Itto-Nakama, K., Yamanaka, D., Ohya, Y., Osada, H., Wang, B., Bader, GD., Boone, C.:
  "BIONIC: biological network integration using convolutions"
  Nat. Methods, 19, 1250-1261 (2022).
• 5. Kubo, K., Itto-Nakama, K., Ohnuki, S., Yashiroda, Y., Li, SC., Kimura, H., Kawamura, Y., Shimamoto, Y., Tominaga, KI., Yamanaka, D., Adachi, Y., Takashima, S., Noda, Y., Boone, C., Ohya, Y.:
  "Jerveratrum-type steroidal alkaloids inhibit β-1,6-glucan biosynthesis in fungal cell walls."
  Microbiol. Spectr., 10, e0087321 (2022).
• 6. Revie, NM., Iyer, KR., Maxson, ME., Zhang, J., Yan, S., Fernandes, CM., Meyer, KJ., Chen, X., Skulska, I., Fogal, M., Sanchez, H., Hossain, S., Li, S., Yashiroda, Y., Hirano, H., Yoshida, M., Osada, H, Boone, C., Shapiro, RS., Andes, DR., Wright, GD., Nodwell, JR., Del Poeta, M., Burke, MD., Whitesell, L., Robbins, N., Cowen, LE.:
  "Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation"
  Nat. Commun., 13, 3634 (2022).
• 7. Persaud, R., Li, SC., Chao, JD., Forestieri, R., Donohue, E., Balgi, AD., Zheng, X., Chao, JT., Yashiroda, Y., Yoshimura, M., Loewen, CJR., Gingras, AC., Boone, C., Av-Gay, Y., Roberge, M., Andersen, RJ.:
  "Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1"
  Cell Chem. Biol., 29, 870-882 (2021).
• 8. Tomita, K., Yashiroda, Y., Matsuo, Y., Piotrowski, JS., Li, SC., Okamoto, R., Yoshimura, M., Kimura, H., Kawamura, Y., Kawamukai, M., Boone, C., Yoshida, M., Nojiri, H., Okada, K.:
  "Genome-wide screening of genes associated with momilactone B sensitivity in the fission yeast Schizosaccharomyces pombe."
  G3 (Bethesda), 11, jkab156 (2021).
• 9. Simpkins, SW., Deshpande, R., Nelson, J., Li, SC., Piotrowski, JS., Ward, HN., Yashiroda, Y., Osada, H., Yoshida, M., Boone, C., Myers, CL.:
  "Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments."
  Nat. Protoc., 14, 415-440 (2019).
• 10. Piotrowski, JS., Li, SC., Deshpande, R., Simpkins, SW., Nelson, J., Yashiroda, Y., Barber, JM., Safizadeh, H., Wilson, E., Okada, H., Gebre, AA., Kubo, K., Torres, NP., LeBlanc, MA., Andrusiak, K., Okamoto, R., Yoshimura, M., van Leeuwen, J., Shirahige, K., Baryshnikova, A., Brown, GW., Hirano, H., Costanzo, M., Andrews, B., Ohya, Y., Osada, H., Yoshida, M., Myers, CL., and Boone, C.:
  "Functional annotation of chemical libraries across diverse biological processes."
  Nat. Chem. Biol., 13, 982-993 (2017).

研究成果（プレスリリース）

• 

  2023年7月11日
  脂肪酸合成を阻害する新たな抗真菌化合物の発見

• 

  2022年12月14日
  免疫抑制剤の新しい作用メカニズムの解明

• 

  2022年10月28日
  二次代謝物シデロフォアによる分裂酵母の適応生育と一次代謝への影響

• 

  2017年7月25日
  化合物の標的機能を決定するツールを開発

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