Research Summary

Selected Publications

• 1.Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilso E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, Leeuwen Jv, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL & Boone C.
  "Functional annotation of chemical libraries across diverse biological processes."
  Nat. Chem. Biol., in press (2017).
• 2.Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Ohno H, Osada H & Fujii N:
  "Screening of a virtual mirror-image library of natural products."
  Chem. Commun., 52, 7653-7656 (2016).
• 3.Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, & Harada A:
  "Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells."
  J. Cell Biol., 215, 121-138 (2016).
• 4.Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H & Suzu S:
  "Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages."
  J. Immunol., 196: 1832-1841 (2016).
• 5.Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, Tsunetsugu-Yokota Y, Suzuki M & Aida Y:
  "Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor."
  PLoS One, 10: e0145573 (2015).
• 6.Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y & Takashima A:
  "Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups."
  Nat. Commun., 6: 10216 (2015).
• 7.Kakisaka M, Sasaki Y, Yamada K, Kondoh Y, Hikono H, Osada H, Tomii K, Saito T & Aida Y:
  "A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein."
  PLoS Pathog., 11: e1005062 (2015).
• 8.Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS & Osada H:
  "RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270."
  J. Antibiot., 68: 293-295 (2015).
• 9.Choi SB, Choong YS, Saito A, Wahab HA, Najimudin N, Watanabe N, Osada H & Ong EBB:
  "In silico investigation of a HIV-1 Vpr inhibitor binding site: potential for virtual screening and anti-HIV drug design."
  Mol. Inform., 11: 742-748 (2014).
• 10.Maeda K, Nakajima Y, Motoyama T, Kitou Y, Kosaki T, Saito T, Nishiuchi T, Kanamaru K, Osada H, Kobayashi T & Kimura M:
  "Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi."
  Lett. Appl. Microbiol., 59: 377-383 (2014).

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