RIKEN Center for Sustainable Resource Science Molecular Structure Characterization Unit
Unit Leader: Hiroyuki Koshino (D.Agr.)
Research Summary

We develop new methods and technologies of NMR and MS analyses for structural elucidation and characterization of novel organic compounds that are found or synthesized in chemistry and related scientific fields such as chemical biology, metabolomics research, and several organic synthetic studies. We provide diverse research support activity for characterization of organic molecules through maintenance and operation of MS, NMR, and CD facilities for all RIKEN researchers. Our research supporting activities include training on open access machines, technical assistance, data acquisition, and spectral data analysis and interpretation. We collaborate with many research groups, and continue to improve our capability and methodology for organic molecular characterization and structural determination by spectroscopic analysis together with organic synthesis.
Main Research Fields
- Chemistry
Related Research Fields
- Interdisciplinary Science & Engineering
- Agricultural Sciences
- Medicine, Dentistry & Pharmacy
Keywords
- Instrumental analysis
- NMR
- Structural elucidation
- Mass spectrometry
- Chemical biology
Selected Publications
- 1.
Moriyama, T., Yoritate, M., Kato, N., Saika, A., Kusuhara, W., Ono, S., Nagatake, T., Koshino, H., Kiya, N., Moritsuka, N., Tanabe, R., Hidaka, Y., Usui, K., Chiba, S., Kudo, N., Nakahashi, R., Igawa, K., Motoba, H., Tomooka, K., Ishikawa, E., Takahashi, S., Kunisawa, J., Yamasaki, S., and Hirai, G.:
"Linkage-editing pseudo-glycans: a reductive α-fluorovinyl-C-glycosylation strategy to create glycan analogs with altered biological activities",
J. Am. Chem. Soc., 146, 2237-2247 (2024). - 2.
Abdelhakim, Islam A., Futamura, Y., Asami, Y., Hanaki, H., Kito, N., Masuda, S., Shibata, A., Muranaka, A., Koshino, H., Shirasu, K., Osada, H., Ishikawa, J., and Takahashi, S.:
"Expression of Syo_1.56 SARP regulator unveils potent elasnin derivatives with antibacterial activity",
J. Nat. Prod., 87, 1459-1470 (2024). - 3.
Takahashi, S., Hama, T., Nogawa, T., Ogawa, N., and Koshino, H.:
"Total synthesis of clostrienose",
ACS Omega, 8, 35382-35392 (2023). - 4.
Tani, H., Yamaga, M., Sekiya, T., Isohama, Y., Koshino, H., Nogawa, T., Yamaki, A., and Takahashi, S.:
"Identification of a new pyrrolyl pyridoindole alkaloid, melpyrrole, and flazin from honey and their cough-suppressing effect in guinea pigs",
J. Agric. Food Chem., 71, 13805-13813 (2023). - 5.
Nogawa, T., Kato, N., Shimizu, T., Okano, A., Futamura, Y., Takahashi, S., Koshino, H., and Osada, H.:
"Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058",
J. Antibiot., 76, 346-350 (2023). - 6.
Muranaka, A., Ban, H., Naito, M., Miyagawa, S., Ueda, M., Yamamoto, S., Harada, M., Takaya, H., Kimura, M., Kobayashi, N., Uchiyama, M., and Tokunaga, Y.:
"Naked-eye-detectable supramolecular sensing system for glutaric acid and isophthalic acid",
Bull. Chem. Soc. Jpn., 95, 1428-1437 (2022). - 7.
Hirai, G., Kato, M., Koshino, H., Nishizawa, E., Oonuma, K., Ota, E., Watanabe, T., Hashizume, D., Tamura, Y., Okada, M., Miyagi, T., and Sodeoka, M.:
"Ganglioside GM3 analogues containing monofluoromethylene-linked sialoside: Synthesis, stereochemical effects, conformational behavior, and biological activities",
JACS Au, 1, 137-146 (2021). - 8.
Nakamura T., Tamada, Yanagi, Y., Itoh, Y., Nemoto, T., Utumi, H., and Kose, K.:
"Development of a superconducting bulk magnet for NMR and MRI",
J. Magn. Reson., 259, 68-75 (2015). - 9.
Takahashi, S., Yasuda, M., Nakamura, T., Hatano, K., Matsuoka, K., and Koshino, H.:
"Synthesis and structural revision of a brominated sesquiterpenoid, aldingenin C",
J. Org. Chem., 79, 9373-9380 (2014). - 10.
Koichi, S., Arisaka, M., Koshino, H., Aoki, A. Iwata, S., Uno, T., and Satoh, H.:
"Chemical structure elucidation from 13C NMR chemical shifts: Efficient data processing using bipartite matching and maximal clique algorithms",
J. Chem. Inf. Model., 54, 1027-1035 (2014).
Related Links
Lab Members
Principal investigator
- Hiroyuki Koshino
- Unit Leader
Core members
- Atsuya Muranaka
- Senior Research Scientist
- Toshihiko Nogawa
- Technical Scientist
- Shun-ya Takahashi
- Special Temporary Research Scientist
- Takashi Nakamura
- Special Temporary Technical Scientist
- Eiyu Imai
- Technical Staff I
Contact Information
308 Chemical Biology Bldg.,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan
Email: koshino@riken.jp