RIKEN Hakubi Research Teams Human Biomimetic System RIKEN Hakubi Research Team
RIKEN Hakubi Team Leader: Masaya Hagiwara (Ph.D.)
Research Summary
The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets. The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.
Main Research Fields
- Complex Systems
Related Research Fields
- Informatics
- Interdisciplinary Science & Engineering
- Mathematical & Physical Sciences
- Chemistry
- Engineering
- Biological Sciences
- Biology
- Medicine, Dentistry & Pharmacy
- Biomedical engineering/Biomaterial science and engineering
- Nano/Microsystems
- Intelligent mechanics/Mechanical systems
Keywords
- In vitro tissue formation
- Tissue imaging
- Organ on a Chip
- Culture Control
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.*Hagiwara, M., Nakase, I.:
“Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells”
Biochemical and Biophysical Research Communications, 507, 297-303, (2018). - 2.*Hagiwara, M., Nobata, R., Kawahara, T.:
“High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations“
Integrative Biology, 10, 306-312, (2018). - 3.*Hagiwara, M., Nobata, R., Kawahara, T.:
“Large scale imaging by fine spatial alignment of multi-scanning data with gel cube device”
Applied Sciences, 8, doi:10.3390/app8020235, (2018). - 4.*Hagiwara, M., Maruta, M., Marumoto, M.:
“In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells”
Tissue Engineering Part C: Methods, 23, 323-332, (2017). - 5.*Hagiwara, M:
“An in vitro?in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells”
Integrative Biology, 8, 861-868, (2016). - 6.*Hagiwara, M., Nobata, R., Kawahara, T.:
“Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations”
Advanced Healthcare Materials, 5, 1566-1571, (2016). - 7.*Hagiwara, M., Peng, F., Ho, CM.:
“In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment”
Scientific Reports, 5, 8054, (2015) - 8.*Hagiwara, M., Kawahara, T., Iijima, T., Arai, F.:
“High-Speed Magnetic Microrobot Actuation in a Microfluidic Chip by a Fine V-Groove Surface”
IEEE Transactions on Robotics, vol. 29, issue 2, pp. 363-372, (2013). - 9.*Hagiwara, M., Kawahara, T., Arai, F.:
“Local Streamline Generation by Mechanical Oscillation in a Microfluidic Chip for Noncontact Cell Manipulations”
Applied Physics Letters, vol. 101, issue 7, pp. 074102-1 - 074102-4, 2012. - 10.*Hagiwara, M., Kawahara, T., Yamanishi, Y., Masuda, T., Arai, F.:
“On-Chip Magnetically Actuated Robot with Ultrasonic Vibration for Single Cell Manipulations”
Lab on a Chip, vol. 11, issue 12, pp. 2049-2054, (2011).
Annual research report
Lab Members
Principal investigator
- Masaya Hagiwara
- RIKEN Hakubi Team Leader
Core members
- Atsushi Takano
- Research Scientist
- Isabel Siew Yin Koh
- Postdoctoral Researcher
- Kasinan Suthiwanich
- Postdoctoral Researcher
- Ayane Kataoka
- Technical Staff I
- Waki Sekine
- Technical Staff I
- Yoshie Yamanaka
- Assistant
- Minori Fukushima
- Research Part-time Worker II
Contact Information
Bioscience Bldg.
2-1 Hirosawa,
Wako, Saitama,
351-0198, Japan
Tel：+81-(0)48-467-3630
Email: masaya.hagiwara [at] riken.jp