RIKEN Hakubi Research Teams Human Biomimetic System RIKEN Hakubi Research Team
RIKEN Hakubi Team Leader: Masaya Hagiwara (Ph.D.)
Research Summary
The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets. The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.
Main Research Fields
- Complex Systems
Related Research Fields
- Informatics
- Interdisciplinary Science & Engineering
- Mathematical & Physical Sciences
- Chemistry
- Engineering
- Biological Sciences
- Biology
- Medicine, Dentistry & Pharmacy
- Biomedical engineering/Biomaterial science and engineering
- Nano/Microsystems
- Intelligent mechanics/Mechanical systems
Keywords
- In vitro tissue formation
- Tissue imaging
- Organ on a Chip
- Culture Control
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Takano, A., Koh, I., and Hagiwara, M.:
"3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device"
Micromachines, 13, 156, (2022) - 2.
Hagiwara, M., Maruyama, H., Akiyama, M., Koh, I., Arai, F.:
"Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation"
Communications Biology volume 4, 808 (2021) - 3.
Hagiwara, M., Koh, I.:
"Engineering approaches to control and design the in vitro environment towards the reconstruction of organs"
Development, Growth & Differentiation, 62, pp158-166 (2020) - 4.
*Hagiwara, M., Nobata, R., Kawahara, T.;
"Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations"
Journal of Visualized Experiments, 145, e5924, (2019) - 5.
*Hagiwara, M., Nakase, I.:
"Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells"
Biochemical and Biophysical Research Communications, 507, 297-303, (2018). - 6.
*Hagiwara, M., Nobata, R., Kawahara, T.:
"High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations"
Integrative Biology, 10, 306-312, (2018). - 7.
*Hagiwara, M., Nobata, R., Kawahara, T.:
"Large scale imaging by fine spatial alignment of multi-scanning data with gel cube device"
Applied Sciences, 8, doi:10.3390/app8020235, (2018). - 8.
*Hagiwara, M., Maruta, M., Marumoto, M.:
"In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells"
Tissue Engineering Part C: Methods, 23, 323-332, (2017). - 9.
*Hagiwara, M:
"An in vitro–in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells"
Integrative Biology, 8, 861-868, (2016). - 10.
*Hagiwara, M., Nobata, R., Kawahara, T.:
"Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations"
Advanced Healthcare Materials, 5, 1566-1571, (2016).
Recent Research Results
Apr. 11, 2023
Simple but revolutionary modular organoids
Annual research report
Related Links
Lab Members
Principal investigator
- Masaya Hagiwara
- RIKEN Hakubi Team Leader
Core members
- Raja Kumar Vadivelu
- Special Postdoctoral Researcher
- Isabel Siew Yin Koh
- Postdoctoral Researcher
- Yen Xuan Ngo
- Postdoctoral Researcher
- Satoko Kinoshita
- Assistant
Careers
| Position | Deadline |
|---|---|
| Seeking a few Technical Staff (CPR-HBS2202) | Open until filled |
| Seeking a Postdoctoral Researcher (CPR-HBS2201) | Open until filled |
Contact Information
Bioscience Bldg.
2-1 Hirosawa,
Wako, Saitama,
351-0198, Japan
Tel：+81-(0)48-467-3630
Email: masaya.hagiwara [at] riken.jp