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RIKEN Hakubi Research Teams Human Biomimetic System RIKEN Hakubi Research Team

RIKEN Hakubi Team Leader: Masaya Hagiwara (Ph.D.)

Research Summary

Masaya  Hagiwara(Ph.D.)

The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets. The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Informatics
  • Interdisciplinary Science & Engineering
  • Mathematical & Physical Sciences
  • Chemistry
  • Engineering
  • Biological Sciences
  • Biology
  • Medicine, Dentistry & Pharmacy
  • Biomedical engineering/Biomaterial science and engineering
  • Nano/Microsystems
  • Intelligent mechanics/Mechanical systems


  • In vitro tissue formation
  • Tissue imaging
  • Organ on a Chip
  • Culture Control

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Hagiwara, M., Nakase, I.:
    “Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells”
    Biochemical and Biophysical Research Communications, 507, 297-303, (2018).
  • 2.*Hagiwara, M., Nobata, R., Kawahara, T.:
    “High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations“
    Integrative Biology, 10, 306-312, (2018).
  • 3.*Hagiwara, M., Nobata, R., Kawahara, T.:
    “Large scale imaging by fine spatial alignment of multi-scanning data with gel cube device”
    Applied Sciences, 8, doi:10.3390/app8020235, (2018).
  • 4.*Hagiwara, M., Maruta, M., Marumoto, M.:
    “In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells”
    Tissue Engineering Part C: Methods, 23, 323-332, (2017).
  • 5.*Hagiwara, M:
    “An in vitro?in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells”
    Integrative Biology, 8, 861-868, (2016).
  • 6.*Hagiwara, M., Nobata, R., Kawahara, T.:
    “Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations”
    Advanced Healthcare Materials, 5, 1566-1571, (2016).
  • 7.*Hagiwara, M., Peng, F., Ho, CM.:
    “In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment”
    Scientific Reports, 5, 8054, (2015)
  • 8.*Hagiwara, M., Kawahara, T., Iijima, T., Arai, F.:
    “High-Speed Magnetic Microrobot Actuation in a Microfluidic Chip by a Fine V-Groove Surface”
    IEEE Transactions on Robotics, vol. 29, issue 2, pp. 363-372, (2013).
  • 9.*Hagiwara, M., Kawahara, T., Arai, F.:
    “Local Streamline Generation by Mechanical Oscillation in a Microfluidic Chip for Noncontact Cell Manipulations”
    Applied Physics Letters, vol. 101, issue 7, pp. 074102-1 - 074102-4, 2012.
  • 10.*Hagiwara, M., Kawahara, T., Yamanishi, Y., Masuda, T., Arai, F.:
    “On-Chip Magnetically Actuated Robot with Ultrasonic Vibration for Single Cell Manipulations”
    Lab on a Chip, vol. 11, issue 12, pp. 2049-2054, (2011).

Annual research report

Lab Members

Principal investigator

Masaya Hagiwara
RIKEN Hakubi Team Leader

Core members

Atsushi Takano
Research Scientist
Isabel Siew Yin Koh
Postdoctoral Researcher
Kasinan Suthiwanich
Postdoctoral Researcher
Ayane Kataoka
Technical Staff I
Waki Sekine
Technical Staff I
Yoshie Yamanaka
Minori Fukushima
Research Part-time Worker II

Contact Information

Bioscience Bldg.
2-1 Hirosawa,
Wako, Saitama,
351-0198, Japan
Email: masaya.hagiwara [at] riken.jp