RIKEN Hakubi Research Teams Human Biomimetic System RIKEN Hakubi Research Team
RIKEN Hakubi Team Leader: Masaya Hagiwara (Ph.D.)
Research Summary
The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets. The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.
Main Research Fields
- Complex Systems
Related Research Fields
- Informatics
- Interdisciplinary Science & Engineering
- Mathematical & Physical Sciences
- Chemistry
- Engineering
- Biological Sciences
- Biology
- Medicine, Dentistry & Pharmacy
- Biomedical engineering/Biomaterial science and engineering
- Nano/Microsystems
- Intelligent mechanics/Mechanical systems
Keywords
- In vitro tissue formation
- Tissue imaging
- Organ on a Chip
- Culture Control
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Koh I, Hagiwara M.:
"Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction"
Communications Biology 7, 177 (2024) - 2.
Koh I, Hagiwara M.
"Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation"
Communications Biology 6(1), 299 (2023) - 3.
Kasinan Suthiwanich, Masaya Hagiwara
"Localization of multiple hydrogels with MultiCUBE platform spatially guides 3D tissue morphogenesis in vitro"
Advanced Material Technologies, 8, 4, (2023) - 4.
Takano, A., Koh, I., and Hagiwara, M.:
"3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device"
Micromachines, 13, 156, (2022) - 5.
Hagiwara, M., Maruyama, H., Akiyama, M., Koh, I., Arai, F.:
"Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation"
Communications Biology volume 4, 808 (2021) - 6.
Hagiwara, M., Koh, I.:
"Engineering approaches to control and design the in vitro environment towards the reconstruction of organs"
Development, Growth & Differentiation, 62, pp158-166 (2020) - 7.
*Hagiwara, M., Nakase, I.:
"Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells"
Biochemical and Biophysical Research Communications, 507, 297-303, (2018). - 8.
*Hagiwara, M., Nobata, R., Kawahara, T.:
"High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations"
Integrative Biology, 10, 306-312, (2018). - 9.
*Hagiwara, M:
"An in vitro–in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells"
Integrative Biology, 8, 861-868, (2016). - 10.
*Hagiwara, M., Nobata, R., Kawahara, T.:
"Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations"
Advanced Healthcare Materials, 5, 1566-1571, (2016).
Recent Research Results
Apr. 11, 2023
Simple but revolutionary modular organoids
Annual research report
Related Links
Lab Members
Principal investigator
- Masaya Hagiwara
- RIKEN Hakubi Team Leader
Core members
- Yen Xuan Ngo
- Postdoctoral Researcher
- Marlar Saw
- Technical Staff I
- Satoko Kinoshita
- Assistant
Contact Information
N404, RIKEN IIB,
6-7-1 Minatojima-minamimachi,
Chuou-ku, Kobe,
650-0047, Japan
Tel：+81-(0)78-569-8870
Email: masaya.hagiwara@riken.jp