研究概要

主要論文

「*」は、理研外のみでの成果です。

• 1. Koh I, Hagiwara M.:
  "Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction"
  Communications Biology 7, 177 (2024)
• 2. Koh I, Hagiwara M.
  "Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation"
  Communications Biology 6(1), 299 (2023)
• 3. Kasinan Suthiwanich, Masaya Hagiwara
  "Localization of multiple hydrogels with MultiCUBE platform spatially guides 3D tissue morphogenesis in vitro"
  Advanced Material Technologies, 8, 4, (2023)
• 4. Takano, A., Koh, I., and Hagiwara, M.:
  "3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by　 Combining 3D Printing with a Cube Device"
  Micromachines, 13, 156, (2022)
• 5. Hagiwara, M., Maruyama, H., Akiyama, M., Koh, I., Arai, F.:
  "Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation"
  Communications Biology volume 4, 808 (2021)
• 6. Hagiwara, M., Koh, I.:
  "Engineering approaches to control and design the in vitro environment towards the reconstruction of organs"
  Development, Growth & Differentiation, 62, pp158-166 (2020)
• 7. *Hagiwara, M., Nakase, I.:
  "Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells"
  Biochemical and Biophysical Research Communications, 507, 297-303, (2018).
• 8. *Hagiwara, M., Nobata, R., Kawahara, T.:
  "High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations"
  Integrative Biology, 10, 306-312, (2018).
• 9. *Hagiwara, M:
  "An in vitro–in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells"
  Integrative Biology, 8, 861-868, (2016).
• 10. *Hagiwara, M., Nobata, R., Kawahara, T.:
  "Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations"
  Advanced Healthcare Materials, 5, 1566-1571, (2016).

研究成果（プレスリリース）

• 

  2023年3月24日
  ミニ臓器に体軸方向を与える技術を開発

• 

  2023年1月31日
  培養ゲルを適材適所に

• 

  2021年6月29日
  細胞は自ら通りやすい道を作り、その道を他の細胞も追随する

研究年次報告書

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