研究概要

主要論文

「*」は、理研外のみでの成果です。

• 1. Takano, A., Koh, I., and Hagiwara, M.:
  "3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device"
  Micromachines, 13, 156, (2022)
• 2. Hagiwara, M., Maruyama, H., Akiyama, M., Koh, I., Arai, F.:
  "Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation"
  Communications Biology volume 4, 808 (2021)
• 3. Hagiwara, M., Koh, I.:
  "Engineering approaches to control and design the in vitro environment towards the reconstruction of organs"
  Development, Growth & Differentiation, 62, pp158-166 (2020)
• 4. *Hagiwara, M., Nobata, R., Kawahara, T.;
  "Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations"
  Journal of Visualized Experiments, 145, e5924, (2019)
• 5. *Hagiwara, M., Nakase, I.:
  "Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells"
  Biochemical and Biophysical Research Communications, 507, 297-303, (2018).
• 6. *Hagiwara, M., Nobata, R., Kawahara, T.:
  "High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations"
  Integrative Biology, 10, 306-312, (2018).
• 7. *Hagiwara, M., Nobata, R., Kawahara, T.:
  "Large scale imaging by fine spatial alignment of multi-scanning data with gel cube device"
  Applied Sciences, 8, doi:10.3390/app8020235, (2018).
• 8. *Hagiwara, M., Maruta, M., Marumoto, M.:
  "In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells"
  Tissue Engineering Part C: Methods, 23, 323-332, (2017).
• 9. *Hagiwara, M:
  "An in vitro–in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells"
  Integrative Biology, 8, 861-868, (2016).
• 10. *Hagiwara, M., Nobata, R., Kawahara, T.:
  "Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations"
  Advanced Healthcare Materials, 5, 1566-1571, (2016).

研究成果（プレスリリース）

• 

  2023年3月24日
  ミニ臓器に体軸方向を与える技術を開発

• 

  2023年1月31日
  培養ゲルを適材適所に

• 

  2021年6月29日
  細胞は自ら通りやすい道を作り、その道を他の細胞も追随する

研究年次報告書

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