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RIKEN Center for Integrative Medical Sciences Laboratory for Medical Science Mathematics

Team Leader: Tatsuhiko Tsunoda (Ph.D., Ph.D.)

Research Summary

Tatsuhiko  Tsunoda(Ph.D., Ph.D.)

Medicine, in the very near future, will be able to provide patients with optimized treatments, such as individualized dosage of drugs and therapies. Patient variability with respect to such treatment response arises from variation in both the patients' genomic DNA as well as from environmental interactions. Our research will be directed towards combining genetic factors obtained from genomic sequence variation analysis/detection with gene-expression profiles obtained from microarray experiments; the final goal being their application to diagnoses and genetic therapies. Modern medicine must strive to avoid side effects stemming from the application of inadequate therapies. Towards this goal, one of the most important contributions we could make is genome-wide association studies for identification of disease and/or drug response related genes/variation. Using next-generation sequencer data, we will/have exhaustively explore variation of individuals' genomes and alterations in cancer genomes to a high quality. We will also develop theoretical frameworks and algorithms, and their practical extensions, for handling the ever increasing genetic variation, clinical and gene expression data, investigating disease-causing genes, and clarifying disease etiology.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Mathematical & Physical Sciences


  • Disease omic analysis
  • Genomic Medicine
  • Precision Medicine
  • Medical Science Mathematics

Selected Publications

  • 1.Shigemizu, D., Iwase, T., Yoshimoto, M., Suzuki, Y., Miya, F., Boroevich, K.A., Katagiri, T., Zembutsu, H., and Tsunoda, T.:
    "The prediction models for postoperative overall survival and disease-free survival in patients with breast cancer"
    Cancer Medicine, 6, 1627-1638 (2017).
  • 2.Fujimoto, A.+, Furuta, M.+, Totoki, Y.+, Tsunoda, T.+, Kato, M.+ (+: co-first), Shiraishi, Y., Tanaka, H., Taniguchi, H., Kawakami, Y., Ueno, M., Gotoh, K., Ariizumi, S., Wardell, C.P., Hayami, S., Nakamura, T., Aikata, H., Arihiro, K., Boroevich, K.A., Abe, T., Nakano, K., Maejima, K., Sasaki-Oku, A., Ohsawa, A., Shibuya, T., Nakamura, H., Hama, N., Hosoda, F., Arai, Y., Ohashi, S., Urushidate, T., Nagae, G., Yamamoto, S., Ueda, H., Tatsuno, K., Ojima, H., Hiraoka, N., Okusaka, T., Kubo, M., Marubashi, S., Yamada, T., Hirano, S., Yamamoto, M., Ohdan, H., Shimada, K., Ishikawa, O., Yamaue, H., Chayama, K., Miyano, S., Aburatani, H., Shibata, T., and Nakagawa, H.:
    "Whole genome mutational landscape and characterization of non-coding and structural mutations in liver cancer"
    Nature Genetics, 48, 500-509 (2016).
  • 3.Fujimoto, A., Furuta, M., Shiraishi, Y., Gotoh, K., Kawakami, Y., Arihiro, K., Nakamura, T., Ueno, M., Ariizumi, S., Hai Nguyen, H., Shigemizu, D., Abe T., Boroevich, KA., Nakano, K., Sasaki, A., Kitada, R., Maejima, K., Yamamoto, Y., Tanaka, H., Shibuya, T., Shibata, T., Ojima, H., Shimada, K., Hayami, S., Shigekawa, Y., Aikata, H., Ohdan, H., Marubashi, S., Yamada, T., Kubo, M., Hirano, S., Ishikawa, O., Yamamoto, M., Yamaue, H., Chayama, K., Miyano, S., Tsunoda, T.*, and Nakagawa, H.*:
    "Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity"
    Nature Communications. 6, 6120 (2015).
  • 4.Fujimoto, A., Totoki, Y., Abe, T., Boroevich, K.A., Hosoda, F., Nguyen, H.H., Aoki, M., Hoshono, N., Kubo, M., Miya, F., Arai, Y., Takahashi, H., Shirakihara, T., Nagasaki, M., Shibuya, T., Nakano, K., Watanabe-Makino, K., Tanaka, H., Nakamura, H., Kusuda, J., Ojima, H., Shimada, K., Okusaka, T., Ueno, M., Shigekawa, Y., Kawakami, Y., Arihiro, K., Ohdan, H., Gotoh, K., Ishikawa, O., Ariizumi, S., Yamamoto, M., Yamada, T., Chayama, K., Kosuge, T., Yamaue, H., Kamatani, N., Miyano, S., Nakagama, H., Nakamura, Y., Tsunoda, T., Shibata, T., and Nakagawa, H.:
    "Whole Genome Sequencing of Liver Cancers Identifies Etiological Influences on Mutation Patterns and Recurrent Mutations in Chromatin Regulators"
    Nature Genetics, 44, 760-764 (2012).
  • 5.Fujimoto, A., Nakagawa, H., Hosono, N., Nakano, K., Abe, T., Boroevich, K.A., Nagasaki, M., Yamaguchi, R., Shibuya, T., Kubo, M., Miyano, S., Nakamura, Y., and Tsunoda, T.:
    "Whole genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing"
    Nature Genetics, 42, 931-936 (2010).
  • 6.The International Cancer Genome Consortium:
    "International network of cancer genome projects"
    Nature, 464, 993-998 (2010).
  • 7.Kato, M., Kawaguchi, T., Ishikawa, S., Umeda, T., Nakamichi, R., Shapero, M.H., Jones, K.W., Nakamura, Y., Aburatani, H., and Tsunoda, T.:
    "Population-genetic nature of copy number variations in the human genome"
    Human Molecular Genetics, 19, 761-773 (2010).
  • 8.The International HapMap Consortium:
    "A second generation human haplotype map of over 3.1 million SNPs"
    Nature, 449, 851-862 (2007).
  • 9.The International HapMap Consortium:
    "A haplotype map of the human genome"
    Nature, 437, 1299-1320 (2005).
  • 10.Tsunoda, T., Lathrop, G.M., Sekine, A., Yamada, R., Takahashi, A., Ohnishi, Y., Tanaka, T., and Nakamura, Y.:
    "Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome"
    Human Molecular Genetics, 13, 1623-1632 (2004).

Related Links

Lab Members

Principal investigator

Tatsuhiko Tsunoda
Team Leader

Core members

Alokanand Sharma
Senior Research Scientist
Artem Lysenko
Research Scientist
Takashi Morizono
Technical Staff I
Keith Anthony Boroevich
Technical Staff I

Contact Information

North Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9556
Fax: +81-(0)45-503-7003
Email: tatsuhiko.tsunoda [at] riken.jp