Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1.Aoyagi R, Ikeda K, Isobe Y, Arita M.
  "Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library."
  J Lipid Res in press (2017)
• 2.Tsugawa H, Ikeda K, Arita M.
  "The importance of bioinformatics for connecting data-driven lipidomics and biological insights."
  Biochim Biophys Acta 1862, 762-765 (2017)
• 3.Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, Arita M, Akiyama M, Murakami M.
  "PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis."
  Nat Commun 8, 14609 (2017)
• 4.Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
  "Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity."
  Cancer Discov 7, 522-538 (2017)
• 5.Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
  "Maternal dietary balance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites."
  Stem Cells 34, 470-482 (2016)
• 6.Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H.
  "Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut."
  Sci Rep 5, 9750 (2015)
• 7.Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, Arita M.
  "18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling."
  J Exp Med 211, 1673-1687 (2014)
• 8.Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M.
  "Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice."
  FASEB J 28, 4036-4043 (2014)
• 9.Kubota T, Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H.
  "Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid."
  FASEB J 28, 586-593 (2014)
• 10.*Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanabe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, Imai Y.
  "The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza."
  Cell 153, 112-125 (2013)

Recent Research Results

• 

  Jun. 5, 2024
  Cracking the aging code: Insights into lipid changes

• 

  Jun. 19, 2020
  Advancing lipidomics: researchers establish atlas of lipids in living organisms

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