Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1.Hirabayashi S., Bhagat S., Matsuki Y., Takegami Y., Uehata T., Kanemaru A., Itoh M., Shirakawa K., Takaori-Kondo A., Takeuchi O., Carninci P., Katayama S., Hayashizaki Y., Kere J., Kawaji H., Murakawa Y.
  NET-CAGE Characterizes Dynamics and Topology of Human Transcribed Cis-regulatory Elements
  Nature Genetics, in press
• 2.Yoshihara M., Araki A., Kasama Y., Sunayama M., Abe M., Nishida K., Kawaji H., Hayashizaki Y., Murakawa Y.
  Hotspots of de novo point mutations in induced pluripotent stem cells.
  Cell Reports, 21:308-315. (2017)
• 3.Murakawa, Y., Yoshihara, M., Kawaji H., Nishikawa M., Zayed H., Suzuki H., Fantom Consortium, Hayashizaki Y.
  Enhanced identification of transcriptinal enhancers provides mechanistic insights into diseases.
  Trends in Genetics 32:76-88. (2016)
• 4.*Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dolken, L., Kempa, S., Schmidt-Supprian, M., Heinemann, U., Wolf, J, Scheidereit, C., Landthaler, M.
  RC3H1 represses the IKK/NF-κB negative feedback regulator A20 by binding to a 3’UTR composite structure-sequence element.
  Nature Communications, 6:7367. (2015)
• 5.*Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., Vinueesa, GG., Ohler, U., Standley, DM., Landthaler, M., Fujiwara, T., Takeuchi, O.
  Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
  Cell, 161 1058-1073. (2015)
• 6.*Rybak-Wolf, A. (#), Jens, M. (#), Murakawa, Y. (#), Herzog, M., Landthaler, M., Rajewsky, N.
  A variety of Dicer substrates in human and C.elegans.
  Cell, 159 1153-1167. (2014)
• 7.*Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M., Heinemann, U.
  Roquin binding to stem-loop mRNAs induces protein dimerization and involves a winged helix-turn-helix motif.
  Nature Communications, 5 5701. (2014)
• 8.*Baltz, AG., Munschauer, M., Schwanhausser, B., Vasile, A., Murakawa, Y., Schueler, M., Youngs, N., Penfold-Brown, D., Drew, K., Milek, M., Wyler, E., Bonneau, R., Selbach, M., Dieterich, C., Landthaler, M.
  The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
  Molecular Cell, 46 674-690. (2012)
• 9.*Murakawa, Y., Sonoda, E., Barber, L.J., Zeng, W., Yokomori, K., Kimura, H., Niimi, A., Lehmann, A., Zhao, G.Y., Hochegger, H., Boulton, SJ., Takeda, S.
  Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.
  Cancer research, 67, 8536-8543. (2007)
• 10.*Zhao, G.Y., Sonoda, E., Barber, L.J., Oka, H., Murakawa, Y., Yamada, K., Ikura, T., Wang, X., Kobayashi, M., Yamamoto, K., Boulton, S.J., Takeda, S.
  A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
  Molecular Cell, 25, 663-675. (2007)

Recent Research Results

• 

  Sep. 27, 2019
  New method provides better understanding of how gene “enhancers” work

Lab Members

Contact Information

1-7-22, Suehiro-cho,
Tsurumi-ku, Yokohama,
Kanagawa, Japan
Email: yasuhiro.murakawa [at] riken.jp