Research Summary

Research Subjects

• Advancement of technologies in reproductive biology
• In vitro development of early mouse embryos

Selected Publications

• 1.Nakao, H., Harada, T., Nakao, K., Kiyonari, H., Inoue, K., Furuta, Y., and Aiba, A.:
  "A possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mouse zygotes."
  Genesis, 54(2):65-77, 2016.
• 2.Yoshida, M., Kajikawa, E., Kurokawa, D., Tokunaga, T., Onishi, A., Yonemura, S., Kobayashi, K., Kiyonari, H., and Aizawa, S.:
  "Conserved and divergent expression patterns of markers of axial development in eutherian mammals."
  Dev. Dyn., 245(1): 67-86, 2016.
• 3.Hara, Y., Tatsumi, K., Yoshida, M., Kajikawa, E., Kiyonari, H., and Kuraku, S.:
  "Optimizing and benchmarking de novo transcriptome sequencing: from library preparation to assembly evaluation."
  BMC Genomics, 16(1):977, 2015.
• 4.Popov, L.M., Marceau, C.D., Starkl, P.M., Lumb, J.H., Shah, J., Guerrera, D. Cooper, R.L., Merakou. C., Bouley. D.M., Meng, W., Kiyonari, H., Takeichi, M., Galli, S.J., Bagnoli, F., Citi, S., Carette, J.E., and Amieva, M.R.:
  "The adherens junctions control susceptibility to Staphylococcus aureus α-toxin."
  Proc. Natl. Acad. Sci. U S A, 112(46): 14337-14342, 2015.
• 5.Hirate, Y., Hirahara, S., Inoue, K., Kiyonari, H., Niwa, H., and Sasaki, H.:
  "Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos."
  Dev. Growth Differ., 57(8): 544-556, 2015.
• 6.Katayama, A., Nakatsuka, A., Eguchi, J., Murakami, K., Teshigawara, S., Kanzaki, M., Nunoue, T., Hida, K., Wada, N., Yasunaka, T., Ikeda, F., Takaki, A., Yamamoto, K., Kiyonari, H., Makino, H., and Wada, J.:
  "Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis."
  Sci. Rep., 5:16920, 2015.
• 7.Imai, Y., Kobayashi, Y., Inoshita, T., Meng, H., Arano, T., Uemura, K., Asano, T., Yoshimi, K., Zhang, CL., Matsumoto, G., Ohtsuka, T., Kageyama, R., Kiyonari, H., Shioi, G., Nukina, N., Hattori, N., and Takahashi, R.:
  "The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway."
  PLoS Genet., 11(9): e1005503, 2015.
• 8.Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima, T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, S., Katagiri, H., Honda, H., Kiyonari, H., Uchida, T., and Asano, T.:
  "Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit."
  J. Biol. Chem., 290(40): 24255-24266, 2015.
• 9.Kurimoto, K., Yabuta, Y., Hayashi, K., Ohta, H., Kiyonari, H., Mitani, T., Moritoki, Y., Kohri, K., Kimura, H., Yamamoto, T., Katou, Y., Shirahige, K., and Saitou, M.:
  "Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells."
  Cell Stem Cell. 16(5): 517-532, 2015.
• 10.Lee, M.S., Hwang, K.S., Oh, H.W., Ji-Ae, K., Kim, H.T., Cho, H.S., Lee, J.J., Yeong Ko, J., Choi, J.H., Jeong, Y.M., You, K.H., Kim, J., Park, D.S., Nam, K.H., Aizawa, S., Kiyonari, H., Shioi, G., Park, J.H., Zhou, W., Kim, N.S., and Kim, C.H.:
  "IFT46 plays an essential role in cilia development."
  Dev. Biol. 400(2): 248-257, 2015.

Recent Research Results

• 

  Jul. 22, 2021
  Genome editing meets marsupials

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