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RIKEN Center for Biosystems Dynamics Research Laboratory for Brain Connectomics Imaging

Team Leader: Takuya Hayashi (M.D., Ph.D.)

Research Summary

Takuya  Hayashi(M.D., Ph.D.)

Using advanced dynamic imaging techniques, we will clarify the interconnections among organs or cells, which are involved in maintaining homeostasis in the body. We specially focus on the unique feature of nervous system—a network architecture and its activity that contribute to adaptive ability related to neural plasticity, regeneration and sociality. We also try to understand mechanism underlining central nervous system function, such in neurodegenerative disease and disorders in self-control.

Main Research Fields

  • Neuroscience & Behavior

Related Research Fields

  • Engineering
  • Clinical Medicine
  • Psychology & Psychiatry

Research Subjects

  • Reorganization of brain network in plasticity
  • Reorganization of brain network in regeneration
  • Transformation and control of brain network in brain disease
  • Sociality, brain network and neurotransmitter

Selected Publications

  • 1. Hayashi, T., Hou, Y., Glasser, M.F., et al.:
    "The nonhuman primate neuroimaging and neuroanatomy project."
    NeuroImage 229, 117726. (2021) doi: 10.1016/j.neuroimage.2021.117726
  • 2. Autio, J.A., Zhu, Q., Li, X., Glasser, M.F., et al.:
    "Minimal specifications for non-human primate MRI: Challenges in standardizing and harmonizing data collection."
    NeuroImage 236, 118082. (2021) doi:10.1016/j.neuroimage.2021.118082
  • 3. Koike, S., Tanaka, S., Okada, T., et al.:
    "Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-level Harmonization across Brain Disorders Throughout the Lifespan."
    NeuroImage:Clinical (in press) doi: 10.1016/j.nicl.2021.102600
  • 4. Aso T, Sugihara G, Murai T, et al.:
    "A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal aging."
    Brain (2020) doi: 10.1093/brain/awaa125
  • 5. Autio JA, Glasser MF, Ose T, et al.:
    "Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing."
    NeuroImage 215, 116800 (2020) doi: 10.1016/j.neuroimage.2020.116800
  • 6. Fukutomi H, Glasser MF, Zhang H, et al.:
    "Neurite imaging reveals microstructural variations in human cerebral cortical gray matter."
    Neuroimage S1053-8119(18). 30105-8 (2018) doi : 10.1016/j.neuroimage.2018.02.017
  • 7. Van Essen, D.C., Donahue, C.J., Coalson, T.S., et al.:
    "Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice.
    Proceedings of the National Academy of Sciences of the United States of America 116(52):26173-26180 (2019.) doi: 10.1073/pnas.1902299116
  • 8. Kikuchi T, Morizane A, Doi D, et al.:
    "Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model."
    Nature 548. 592–596 (2017) doi: 10.1038/nature23664
  • 9. Hayashi T, Ko JH, Strafella AP, Dagher A.:
    "Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving."
    Proceedings of the National Academy of Sciences of the United States of America 110(11). 4422-4427 (2013) doi: 10.1073/pnas.1212185110
  • 10. Hayashi T, Wakao S, Kitada M, et al.:
    "Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques."
    Journal of Clinical Investigation 123(1). 272-284 (2013) doi: 10.1172/JCI62516

Recent Research Results

Related Links

Lab Members

Principal investigator

Takuya Hayashi
Team Leader

Core members

Toshihiko Aso
Deputy Team Leader
Joonas Autio
Senior Scientist
Takuro Ikeda
Research Scientist
Akiko Uematsu
Research Scientist
Takashi Azuma
Technical Scientist
Takayuki Ose
Technical Scientist
Masahiro Ohno
Expert Technician
Yuki Matsumoto
Technical Staff I
Tomoko Ishibuchi
Technical Staff I
Reiko Kobayashi
Technical Staff I

Contact Information

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Email: takuya.hayashi [at] riken.jp