RIKEN Center for Biosystems Dynamics Research Laboratory for Brain Connectomics Imaging
Team Leader: Takuya Hayashi (M.D., Ph.D.)
Research Summary

Using advanced dynamic imaging techniques, we will clarify the interconnections among organs or cells, which are involved in maintaining homeostasis in the body. We specially focus on the unique feature of nervous system—a network architecture and its activity that contribute to adaptive ability related to neural plasticity, regeneration and sociality. We also try to understand mechanism underlining central nervous system function, such in neurodegenerative disease and disorders in self-control.
Main Research Fields
- Neuroscience & Behavior
Related Research Fields
- Engineering
- Clinical Medicine
- Psychology & Psychiatry
Research Subjects
- Reorganization of brain network in plasticity
- Reorganization of brain network in regeneration
- Transformation and control of brain network in brain disease
- Sociality, brain network and neurotransmitter
Selected Publications
- 1.
Hayashi, T., Hou, Y., Glasser, M.F., et al.:
"The nonhuman primate neuroimaging and neuroanatomy project."
NeuroImage 229, 117726. (2021) doi: 10.1016/j.neuroimage.2021.117726 - 2.
Autio, J.A., Zhu, Q., Li, X., Glasser, M.F., et al.:
"Minimal specifications for non-human primate MRI: Challenges in standardizing and harmonizing data collection."
NeuroImage 236, 118082. (2021) doi:10.1016/j.neuroimage.2021.118082 - 3.
Koike, S., Tanaka, S., Okada, T., et al.:
"Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-level Harmonization across Brain Disorders Throughout the Lifespan."
NeuroImage:Clinical (in press) doi: 10.1016/j.nicl.2021.102600 - 4.
Aso T, Sugihara G, Murai T, et al.:
"A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal aging."
Brain (2020) doi: 10.1093/brain/awaa125 - 5.
Autio JA, Glasser MF, Ose T, et al.:
"Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing."
NeuroImage 215, 116800 (2020) doi: 10.1016/j.neuroimage.2020.116800 - 6.
Fukutomi H, Glasser MF, Zhang H, et al.:
"Neurite imaging reveals microstructural variations in human cerebral cortical gray matter."
Neuroimage S1053-8119(18). 30105-8 (2018) doi : 10.1016/j.neuroimage.2018.02.017 - 7.
Van Essen, D.C., Donahue, C.J., Coalson, T.S., et al.:
"Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice.
Proceedings of the National Academy of Sciences of the United States of America 116(52):26173-26180 (2019.) doi: 10.1073/pnas.1902299116 - 8.
Kikuchi T, Morizane A, Doi D, et al.:
"Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model."
Nature 548. 592–596 (2017) doi: 10.1038/nature23664 - 9.
Hayashi T, Ko JH, Strafella AP, Dagher A.:
"Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving."
Proceedings of the National Academy of Sciences of the United States of America 110(11). 4422-4427 (2013) doi: 10.1073/pnas.1212185110 - 10.
Hayashi T, Wakao S, Kitada M, et al.:
"Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques."
Journal of Clinical Investigation 123(1). 272-284 (2013) doi: 10.1172/JCI62516
Recent Research Results
May 18, 2020
A new biomarker for the aging brain
Related Links
Lab Members
Principal investigator
- Takuya Hayashi
- Team Leader
Core members
- Toshihiko Aso
- Deputy Team Leader
- Joonas Autio
- Senior Scientist
- Takuro Ikeda
- Research Scientist
- Akiko Uematsu
- Research Scientist
- Takashi Azuma
- Technical Scientist
- Takayuki Ose
- Technical Scientist
- Masahiro Ohno
- Expert Technician
- Yuki Matsumoto
- Technical Staff I
- Tomoko Ishibuchi
- Technical Staff I
- Reiko Kobayashi
- Technical Staff I
Contact Information
6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Email: takuya.hayashi [at] riken.jp