RIKEN Center for Biosystems Dynamics Research Laboratory for Brain Connectomics Imaging

Team Director: Takuya Hayashi (M.D., Ph.D.)

Japanese Page

Research Summary

Our laboratory focuses on developing non-invasive, high-precision MRI technology to elucidate brain function, structure, and connectivity in humans and non-human primates. We are creating standard brain templates and atlases utilizing multi-scale and multi-modal brain imaging data to develop essential brain maps for neuroscience research. Furthermore, we investigate the relationships between microscale phenomena (such as genetic polymorphisms, gene expression, and neural activity) and individual-level phenomena (including developmental environment and individual behavior). Through these multi-scale observations, we aim to understand and predict individual behavior.

Research Subjects:

Reorganization of brain network in plasticity
Reorganization of brain network in regeneration
Transformation and control of brain network in brain disease
Sociality, brain network and neurotransmitter

Main Research Fields

Biology

Related Research Fields

Engineering
Complex Systems
Social Sciences
Biological Sciences
Medicine, Dentistry & Pharmacy
Brain sciences and related fields
Neuroscience and related fields
General internal medicine and related fields

Keywords

Neuroscience
Imaging
Brain imaging and connectome analysis
MRI

Selected Publications

1. Autio, J.A., Kimura., I, Ose, T., Matsumoto, T., Ohno. M., Urushibata,Y., Ikeda, T., Glasser, M.F., Van Essen. D.C.,Hayashi, T.:
"Mapping Vascular Network Architecture in Primate Brain Using Ferumoxytol-Weighted Laminar MRI"
eLife, 2024 (in press)
2. Ikeda, T., Autio, J.A., Kawasaki, A., Takeda, C., Ose, T., Takada, M., Van Essen, D. C., Glasser, M. F., and Hayashi, T.:
"Cortical adaptation of the night monkey to a nocturnal niche environment: a comparative non-invasive T1w/T2w myelin study"
Brain Struct. Funct., (2022)
3. Ose, T., Autio, J.A., Ohno, M., Stephen, F., Uematsu, A., Kawasaki, A., Takeda, C., Hori, Y., Nishigori, K., Nakako, T., Yokoyama, C., Nagata, H., Yamamori, T., Van Essen, D. C., Glasser, M.F., Watabe, H., and Hayashi, T.
"Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain"
Neuroimage 250, 118965–118965, (2022)
4. Hayashi, T., Hou, Y., Glasser, M.F., et al.
"The nonhuman primate neuroimaging and neuroanatomy project"
NeuroImage 229, 117726. (2021)
5. Koike, S., Tanaka, S., Okada, T., et al.
"Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-level Harmonization across Brain Disorders Throughout the Lifespan"
NeuroImage:Clinical (2021)
6. Fukutomi H, Glasser MF, Zhang H, et al.
"Neurite imaging reveals microstructural variations in human cerebral cortical gray matter"
Neuroimage S1053-8119(18). 30105-8 (2018)
7. Van Essen, D.C., Donahue, C.J., Coalson, T.S., et al.
"Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice."
Proceedings of the National Academy of Sciences of the United States of America 116(52):26173-26180 (2019)
8. Kikuchi T, Morizane A, Doi D, et al.
"Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model."
Nature 548. 592–596 (2017)
9. Hayashi T, Ko JH, Strafella AP, Dagher A.:
"Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving."
Proceedings of the National Academy of Sciences of the United States of America 110(11). 4422-4427 (2013)
10. Hayashi T, Wakao S, Kitada M, et al.
"Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques."
Journal of Clinical Investigation 123(1). 272-284 (2013)