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RIKEN Center for Biosystems Dynamics Research Laboratory for Brain Connectomics Imaging

Team Leader: Takuya Hayashi (M.D., Ph.D.)

Research Summary

Takuya  Hayashi(M.D., Ph.D.)

Using advanced dynamic imaging techniques, we will clarify the interconnections among organs or cells, which are involved in maintaining homeostasis in the body. We specially focus on the unique feature of nervous system—a network architecture and its activity that contribute to adaptive ability related to neural plasticity, regeneration and sociality. We also try to understand mechanism underlining central nervous system function, such in neurodegenerative disease and disorders in self-control.

Main Research Fields

  • Neuroscience & Behavior

Related Research Fields

  • Engineering
  • Clinical Medicine
  • Psychology & Psychiatry

Research Subjects

  • Reorganization of brain network in plasticity
  • Reorganization of brain network in regeneration
  • Transformation and control of brain network in brain disease
  • Sociality, brain network and neurotransmitter

Selected Publications

  • 1.Takenobu Y, Hayashi T, Moriwaki H, Nagatsuka K, Naritomi H, Fukuyama H.:
    “Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke”
    Neuroimage Clin, 4, 201-208 (2014).
  • 2.Hayashi T, Onoe H.:
    “Neuroimaging for optimization of stem cell therapy in Parkinson's disease”
    Expert Opin Biol Ther, 13(12), 1631-1638 (2013).
  • 3.Yokoyama, C; Kawasaki, A; Hayashi, T; Onoe, H.:
    “Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets”
    Cereb Cortex, 23(9), 2136-2145 (2013).
  • 4.Hayashi T, Ko JH, Strafella AP, Dagher A.:
    “Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving”
    Proc Natl Acad Sci U S A, 110(11), 4422-4427 (2013).
  • 5.Hayashi T, Shimazawa M, Watabe H, Ose T, Inokuchi Y, Ito Y, Yamanaka H, Urayama S, Watanabe Y, Hara H, Onoe H.:
    “Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma.”
    Mol Neurodegener, 18(8), 4 (2013).
  • 6.Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.:
    “Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.”
    J Clin Invest, 123(1), 272-284 (2013).
  • 7.Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H.:
    “Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys.”
    Synapse.64(8):594-601 (2010)
  • 8.Wakao S, Hayashi T, Kitada M, Kohama M, Matsue D, Teramoto N, Ose T, Itokazu Y, Koshino K, Watabe H, Iida H, Takamoto T, Tabata Y, Dezawa M.:
    “Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration.”
    Exp Neurol, 223(2), 537-547 (2010).
  • 9.Ikoma Y, Watabe H, Hayashi T, Miyake Y, Teramoto N, Minato K, Iida H.:
    “Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride.”
    J Cereb Blood Flow Metab, 30(3), 663-673 (2010).
  • 10.Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N.:
    “Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.”
    J Clin Invest, 115(1), 102-109 (2005).

Recent Research Results

Related Links

Lab Members

Principal investigator

Takuya Hayashi
Team Leader

Core members

Toshihiko Aso
Deputy Team Leader
Chihiro Yokoyama
Senior Scientist
Joonas Autio
Research Scientist
Kyosuke Watanabe
Research Scientist
Akihiro Kawasaki
Technical Scientist
Chiho Takeda
Technical Scientist
Takayuki Ose
Expert Technician
Masahiro Ohno
Expert Technician
Reiko Kobayashi
Technical Staff I
Hanako Hirose
Temporary Staffing

Contact Information

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Email: takuya.hayashi [at] riken.jp