Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Enomoto Y, Katsura H, Fujimura T, Ogata A, Baba S, Yamaoka A, Kihara M, Abe T, Nishimura O, Kadota M, Hazama D, Tanaka Y, Maniwa Y, Nagano T and Morimoto M.:
  "Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis."
  Nature Communications 14, Article number: 4956 (2023)
• 2. Fujimura T, Enomoto Y, Katsura H, Ogawa T, Baba S,, Ogata A, Yamaoka A, Shiroguchi K and Morimoto M.:
  "Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics."
  Stem Cells 41(8), 809–820 (2023)
• 3. Kishimoto K, Iwasawa K, Sorel A, Ferran-Heredia C, Han L, Morimoto M, Wells JM, Takebe T and Zorn AM.:
  "Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies."
  Nature Protocols 17, 2699–2719 (2022)
• 4. Kiyokawa H, Yamaoka A, Matsuoka C, Tokuhara T, Abe T and Morimoto M.:
  "Airway basal stem cells reutilize the embryonicproliferation regulator, Tgfb-Id2 axis, for tissue regeneration."
  Developmental Cell vol. 56 (2021)
• 5. Kishimoto K, Furukawa KT, Luz-Madrigal A, Yamaoka A, Matsuoka C, Habu M, Alev C, Zorn AM and Morimoto M.:
  "Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells."
  Nature Communications vol. 11: 4159 (2020)
• 6. Kishimoto K, Tamura M, Nishita M, Minami Y, Yamaoka A, Abe T, Shigeta M and Morimoto M.:
  "Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus."
  Nature Communications vol. 9: 2816 (2018)
• 7. Tsao P, Matsuoka C, Wei SC, Sato A, Sato S, Chena HK, Ling TY, Mori M, Cardoso WV and Morimoto M.:
  "Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity."
  Proc. Natl. Acad. Sci. USA 113, 8242-7 (2016)
• 8. Noguchi M, Sumiyama K and Morimoto M.:
  "Directed migration of pulmonary neuroendocrine cells toward airway branches organizes the stereotypic location of neuroepithelial bodies."
  Cell Reports 13, 2679-86 (2015)
• 9. The FANTOM consortium.
  "A promoter-level mammalian expression atlas."
  Nature 507.462-470 (2014)
• 10. *Morimoto M,Takahashi Y, Endo M and Saga Y.:
  "The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity."
  Nature 435.354-9 (2005)

Recent Research Results

• 

  Dec. 14, 2022
  An experimental strategy for recreating organ formation in the lab

• 

  Nov. 13, 2020
  Reconstructing the cellular signaling pathways that shape trachea development

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