Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1.*Gebala V, Collins R, Geudens I, Phng LK* and Gerhardt H* (*equal contribution):
  "Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo"
  Nature Cell Biology 18(4), 443 - 451 (2016)
• 2.*Franco CA, Jones ML, Bernabeu MO, Geudens I, Mathivet T, Rosa A, Lopes FM, Lima AP, Ragab A, Collins RT, Phng LK, Coveney PV and Gerhardt G:
  "Dynamic endothelial cell rearrangements drive developmental vessel regression"
  PLOS BIOLOGY 13(4):e1002125 (2015).
• 3.*Phng LK, Gebala V, Bentley K, Philippides A, Wacker A, Mathivet T, Sauteur L, Stanchi S, HG Belting, Affolter M and Holger Gerhardt:
  "Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization"
  Developmental Cell 32, 123 - 132 (2015)
• 4.*Phng LK*, Stanchi F and Gerhardt H* (*corresponding authors):
  "Filopodia are dispensable for endothelial tip cell guidance"
  Development 140, 4031 - 4040 (2013)
• 5.*De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, *Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P.
  "Role of PFKFB3-driven glycolysis in vessel sprouting"
  Cell 154, 651-663 (2013)
• 6.*Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M.
  "Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase"
  Nature 473, 234-238 (2011)
• 7.*Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, Ondr JK, Rao S, Lang RA, Thurston G and Gerhardt H:
  "Nrarp coordinates endothelial Notch and Wnt signalling to control vessel density in angiogenesis"
  Developmental Cell 16, 70 - 82 (2009)
• 8.*Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Ireula-Arispe ML, Kalén M, Gerhardt H and Betsholtz C:
  "Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis"
  Nature 445, 776 - 770 (2007)

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