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RIKEN Baton Zone Program Bio-chemical Production Laboratory

Team Leader Yoshihide Yachi
Deputy Team Leader Tomokazu Shirai (Ph.D.)

Research Summary

Yoshihide Yachi Tomokazu Shirai

We are studying the following in order to produce bio-butadiene by microorganisms and realize bio-polybutadiene.

  • 1.Improve the activity of butadiene-producing microorganisms.
    The enzyme of the key reaction is highly activated by the enzyme engineering method, and at the same time, the intracellular metabolism is optimized by using the synthetic biology technology to improve the productivity.
  • 2.Purification of biobutadiene produced in the gas phase of the fermenter
    By-products of fermentation may include polymerization inhibitors. Based on the polymerization technology, we will develop a concentration/purification process and develop a process that can produce commercially viable butadiene.

[Integrated Collaborative Research with Zeon Corporation]

Main Research Fields

  • Engineering

Related Research Fields

  • Chemistry
  • Biology
  • Biofunction/Bioprocess


  • enzyme engineering
  • synthetic biology
  • fermentation
  • microorganism
  • butadiene

Lab Members

Principal investigator

Yoshihide Yachi
Team Leader

Core members

Tomokazu Shirai
Deputy Team Leader
Niina Kurokawa
Visiting Scientist
Kunihiro Goto
Visiting Scientist
Takumi Sonoda
Visiting Scientist
Yukio Takagishi
Visiting Scientist
Leo Tsunoi
Visiting Scientist
Koya Nukaga
Visiting Scientist
Miyuki Hayashi
Visiting Technician
Mariko Fujikawa
Visiting Technician
Mami Yoshida
Visiting Technician
Miki Ugawa
Administrative Part-time Worker I

Contact Information

1-6 Suehiro-cho, Tsurumi-ku,
Yokohama, Kanagawa,
240-0035, Japan
Email: yoshihide.yachi [at] riken.jp