RIKEN Center for Brain Science Laboratory for Glia-Neuron Circuit Dynamics
Team Leader: Jun Nagai (Ph.D.)
Research Summary
The lab’s mission is to discover fundamental mechanisms how the brain functions and malfunctions at molecular, cellular, circuit and behavioral levels by including “the other half” of the CNS; glial cells. Studies about astrocytes, a type of glia that tile the entire brain and structurally and functionally interact with neurons, synapses and other glia, have lagged behind partially due to the lack of tools. By developing and utilizing opto-/pharmaco-genetic, imaging, molecular biology and electrophysiology tools, the team aims to unveil astrocyte contributions to adaptive and maladaptive animal behaviors for delivering insights on future therapeutics.
Main Research Fields
- Biological Sciences
Related Research Fields
- Complex Systems
- Biology
- Neurophysiology/General neuroscience, Neurochemistry/Neuropharmacology
- Animal physiology/Animal behavior
- Molecular biology
Keywords
- Adaptive behavior
- Cognition and emotion
- Glia
- Cellular physiology
- Genetics
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Nagai, J., Bellafard, A., Qu, Z., Yu, X., Ollivier, M., Gangwani, M.R., Diaz-Castro, B., Coppola, G., Schumacher, S.M., Golshani, P., Gradinaru, V., Khakh, B.S.
"Specific and behaviourally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK."
Neuron in press. (2021). - 2.
*1Wang, W., 1Schuette, P.J., Nagai, J., Tobias, B.C., Cuccovia V Reis, F.M., Ji, S., de Lima, M.A.X., La-Vu, M.Q., Maesta-Pereira, S., Chakerian, M., Leonard, S.J., Lin, L., Severino, A.L., Cahill, C.M., Canteras, N.S., Khakh, B.S., Kao, J.C., Adhikari, A. (1co-first authors)
"Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats."
Neuron 109(11):1848-1860. (2021). - 3.
1Nagai, J., 1Yu, X., Papouin, T., Cheong, E., Freeman, M.R., Monk, K.R., Hastings, M.H., Haydon, P.G., Rowitch, D., Shaham, S., Khakh, B.S. (1co-first authors)
"Behaviorally consequential astrocytic regulation of neural circuits."
Neuron 109(4):576-596. (2021). - 4.
*1Yu, X., 1Nagai, J., Marti, M., Coppola, G., Babu, M. M., Khakh, B.S.
"Context-specificastrocyte molecular responses are phenotypically exploitable."
Neuron 108(6):1146-1162. (2020). (1co-first authors) - 5.
*1Yu, X., 1Nagai, J., Khakh, B.S. (1co-first authors)
"Improved tools to study astrocytes."
Nature Reviews Neuroscience 21,121-138. (2020). - 6.
*Nagai, J., Rajbhandari, A.K., Gangwani, M.R., Hachisuka, A., Coppola, G., Masmanidis, S.C., Fanselow, M.S., Khakh, B.S.
"Hyperactivity with disrupted attention induced by activation of an astrocyte synaptogenic cue."
Cell 177(5), 1280-92. (2019). - 7.
*Lobas, M., Tao, R., Nagai, J., Kronschlager, M.T., Borden, P., Marvin, J.S., Looger, L.L., Khakh, B.S.
"A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP."
Nature Communications, 10, 711. (2019) - 8.
*Yu, X., Taylor, A.M.W., Nagai, J., Golshani, P., Evans, C.J., Khakh, B.S.
"Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior."
Neuron, 99(6), 1170-87. (2018). - 9.
*Nagai, J., Baba, R., Ohshima, T.
"CRMPs function in neurons and glial cells: a potential therapeutic target for neurodegenerative disease and CNS injury."
Molecular Neurobiology, 54(6), 4243-42. (2017) - 10.
*Nagai, J., Owada, K., Kitamura, Y., Goshima, Y., Ohshima, T.
"Inhibition of CRMP2 phosphorylation repairs CNS by regulating neurotrophic and inhibitory responses."
Experimental Neurology, 277, 283-95. (2016)
Related Links
Lab Members
Principal investigator
- Jun Nagai
- Team Leader
Careers
Position | Deadline |
---|---|
Seeking a Research Scientist (W23338) | Open until filled |
Contact Information
Central building, 6F, S602
2-1 Hirosawa
Wako, Saitama
351-0198, Japan
Tel:+81-(0)48-467-6896
Fax:+81-(0)48-467-6899
Email: jun.nagai [at] riken.jp