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RIKEN Center for Brain Science Laboratory for Haptic Perception and Cognitive Physiology

Team Director: Masanori Murayama (Ph.D.)

Research Summary

Masanori Murayama(Ph.D.)

Little is known about how neurons integrate feedback and feed forward information for animal behavior. To understand it, we focus on the causal relationship between behavior and neural activity at the single-cell, micro-circuit and network levels. We use multidisciplinary techniques including 2-photon microscopy, fiberoptic imaging, macro-brain imaging, optogenetic techniques and electrophysiological recordings, in awake and anesthetized animals. We are also interested in developing new techniques to discover novel neural activities that can be used for understanding brain functions and animal behavior.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Biological Sciences

Keywords

  • Consciousness
  • Perception
  • Mouse
  • Neocortex
  • Dendrite

Selected Publications

    • 1. Saito Y., Osako Y., Odagawa M., Oisi Y., Matsubara C., Kato S., Kobayashi K., Morita M., Johansen JP., Murayama M.:
      "Amygdalo-cortical dialogue underlies memory enhancement by emotional association"
      Neuron 113(6) 931-948 e9(2025)
    • 2. Ota K., Oisi Y., Suzuki T., Ikeda M., Ito Y., Ito T., Uwamori H., Kobayashi K., Kobayashi M., Odagawa M., Matsubara C., Kuroiwa Y., Horikoshi M., Matsushita J., Hioki H., Ohkura M., Nakai J., Oizumi M., Miyawaki A., Aonishi T., Ode T., Murayama M.:
      "Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas"
      Neuron 109(11) 1810-1824.e9(2021)
    • 3. Miyamoto D., Hirai D., Fung CC., Inutsuka A., Odagawa M., Suzuki T., Boehringer R., Adaikkan C., Matsubara C., Matsuki N., Fukai T., McHugh TJ., Yamanaka A., Murayama M.:
      "Top-down cortical input during NREM sleep consolidates perceptual memory"
      Science, 352(6291):1315-8. (2016).
      10.1126/science.aaf0902
    • 4. Hirasawa N., Yamada K., and Murayama M.:
      "Brief hind paw stimulation is sufficient to induce delayed somatosensory discrimination learning in C57BL/6 mice."
      Behavioural Brain Research, Volume 301, 15 March 2016, Pages 102–109
      10.1016/j.bbr.2015.12.024
    • 5. Miyamoto D., Murayama M.:
      "The fiber-optic imaging and manipulation of neural activity during animal behavior."
      Neuroscience Research. H 103 1-9 (2016)
      10.1016/j.neures.2015.09.004
    • 6. Manita S., Suzuki T., Homma C., Matsumoto T., Odagawa M., Yamada K., Ota K., Matsubara C., Inutsuka A., Sato M., Ohkura M., Yamanaka A., Yanagawa Y., Nakai J., Hayashi Y., Larkum M.E., Murayama M.:
      "A Top-Down Cortical Circuit for Accurate Sensory Perception."
      Neuron 86(5) 1304-1316 (2015)
      10.1016/j.neuron.2015.05.006
    • 7. Palmer LM., Murayama M., Larkum ME.:
      "Inhibitory Regulation of Dendritic Activity in vivo."
      Front Neural Circuits. 6:26, (2012)
      10.3389/fncir.2012.00026
    • 8. Palmer LM., Schulz JM., Murphy SC., Ledergerber D., Murayama M., *Larkum ME.:
      "The Cellular Basis of GABAb-Mediated Interhemispheric Inhibition" Science 24;335(6071):989-93, (2012)
      10.1126/science.1217276
    • 9. Lütcke H.*, Murayama M.*, Hahn T., Margolis DJ., Astori S., Zum Alten Borgloh SM., Göbel W., Yang Y., Tang W., Kügler S., Sprengel R., Nagai T., Miyawaki A., Larkum ME., Helmchen F., Hasan MT (* Equal contribution).:
      "Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice"
      Frontiers in Neural Circuits, 4;9 (2010)
      10.3389/fncir.2010.00009
    • 10. Murayama M., Pérez-Garci E., Nevian T., Bock T., Senn W., Larkum ME.:
      "Dendritic encoding of sensory stimuli controlled by deep cortical interneurons"
      Nature 457(7233) 1137-1141 (2009)

    Recent Research Results

    Related Links

    Lab Members

    Principal investigator

    Masanori Murayama
    Team Director

    Core members

    Yasuhiro Oisi
    Research Scientist
    Hiroyuki Uwamori
    Research Scientist
    Ikumi Oomoto
    Special Postdoctoral Researcher
    Kotaro Ishizu
    Special Postdoctoral Researcher
    Yusuke Atsumi
    Research Associate
    Tomoki Osuka
    Research Associate
    Toshiki Tani
    Technical Scientist
    Maya Odagawa
    Technical Staff I
    Chihiro Honma
    Technical Staff I
    Tomomitsu Karaki
    Technical Staff I
    Yuri Shinomoto
    Technical Staff I
    Chie Matsubara
    Technical Staff I
    Midori Kobayashi
    Technical Staff II
    Mami Suzuki
    Assistant

    Contact Information

    2-1 Hirosawa, Wako, Saitama 351-0198, Japan
    Email: masanori.murayama@riken.jp

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