Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1.Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R , Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato XD, Inoue UY, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T.:
  "Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment."
  Elife. 12, e89376. (2024)
• 2.Temma Y, Obi-Nagata K, Hoshiba Y, Miyake R , Katayama Y, Hagihara H, Suzuki N, Miyakawa T, Nakayama KI, Hayashi-Takagi A.:
  "Effect of brain acidification on depression-related behaviors in diabetes mellitus."
  Front. Psychiatry. 14, 1277097. (2023)
• 3.Obi-Nagata K, Suzuki N, Miyake R , MacDonald ML, Fish KN, Ozawa K, Nagahama K, Okimura T, Tanaka S, Kano M, Fukazawa Y, Sweet RA, Hayashi-Takagi A.:
  "Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders."
  Sci. Adv. 9, e5973. (2023)
• 4.Hayashi-Takagi A.:
  "To fire or not to fire: decisions mediated by localized processing and dendritic spikes."
  Nat Rev Neurosci. 24, 194. (2023)
• 5.Hayashi-Takagi A.:
  "Constructive understanding of multi-scale dynamism of psychiatric disorders."
  Neurosci Res. 175, 1-2. (2022)
• 6.Jo SH, Inoue T, Hayashi-Takagi A.:
  "Multi-Scale Understanding of NMDA Receptor Function in Schizophrenia."
  Biomolecules. 10, 1172. (2020)
• 7.Tsutsumi S, Hayashi-Takagi A.:
  "Optical interrogation of multi-scale neuronal plasticity underlying behavioral learning."
  Curr Opin Neurobiol. 67, 8-15. (2020)
• 8.*Kawamura A, Katayama Y, Nishiyama M, Shoji H, Tokuoka K, Ueta Y, Miyata M, Isa T, Miyakawa T, Hayashi-Takagi A, Nakayama KI.:
  "Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice."
  Hum Mol Genet. 29, 1274-1291. (2020)
• 9.*Sasaki Y, Oshikawa M, Bharmoria P, Kouno H, Hayashi-Takagi A, Sato M, Ajioka I, Yanai N, Kimizuka N.:
  "Near-Infrared Optogenetic Genome Engineering Based on Photon-Upconversion Hydrogels."
  Angew Chem Int Ed Engl. 58, 17827-17833. (2019)
• 10.*Obi-Nagata K, Temma Y, Hayashi-Takagi A.:
  "Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model."
  Proc Jpn Acad Ser B Phys Biol Sci. 95, 179-197. (2019)

Recent Research Results

• 

  Oct. 3, 2023
  Extra-large synapses could be a cause of schizophrenia

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