RIKEN Center for Brain Science Laboratory for Multi-scale Biological Psychiatry
Team Leader: Akiko Hayashi-Takagi (M.D., Ph.D.)
Research Summary
Despite extensive research, psychiatric disorders remain poorly understood. Recent works have identified contributory factors for the disorders to be susceptible gene variants (molecular), synaptopathy (cellular), and alteration in neuronal circuits (circuit), which probably results in behavioral manifestations (individual layer). However, the relationship between each layer remains unknown, which hinders the mechanistic understanding of the disorders. Thus, we aim to gain a constructive understanding of the multi-scale hierarchical nature of the brain. This strategy would causally identify the contributory factors for psychiatric disorders, which could provide the knowledge necessary to establish circuit-centric therapeutics as well as molecular-based drug designs.
Main Research Fields
- Medicine, Dentistry & Pharmacy
Related Research Fields
- Biological Sciences
- Biology
- General Neuroscience
- Psychiatric science
Keywords
- Psychiatric disorders
- Synapse
- Multi-scale
- 2-photon imaging
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.*Obi-Nagata K, Temma Y, Hayashi-Takagi A.:
"Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model."
Proc Jpn Acad Ser B Phys Biol Sci. 95, 179-197. (2019) - 2.*Hoshiba Y, Wada T, Hayashi-Takagi A.:
"Synaptic Ensemble Underlying the Selection and Consolidation of Neuronal Circuits during Learning."
Front Neural Circuits. 11, 1-12. (2017) - 3.*Shirai F, Hayashi-Takagi A.:
"Optogenetics: Applications in psychiatric research."
Psychiatry Clin Neurosci. 71 (6), 363-372. (2017) - 4.*Hayashi-Takagi A.:
"Synapse pathology and translational applications for schizophrenia."
Neurosci Res. 114, 3-8. (2017) - 5.*Hayashi-Takagi A, Yagishita S, Nakamura M, Shirai F, Wu YI, Loshbaugh AL, Kuhlman B, Hahn KM, Kasai H.:
"Labelling and optical erasure of synaptic memory traces in the motor cortex."
Nature, 525 (7569), 333-338. (2015) - 6.*Yagishita S, Hayashi-Takagi A, Ellis-Davies GC, Urakubo H, Ishii S, Kasai H.:
"A critical time window for dopamine actions on the structural plasticity of dendritic spines."
Science. 345 (6204), 1616-1620. (2014) - 7.*Hayashi-Takagi A, Araki Y, Nakamura M, Vollrath B, Duron SG, Yan Z, Kasai H, Huganir RL, Campbell DA, Sawa A.:
"PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence."
Proc Natl Acad Sci U S A. 111 (17), 920-928. (2014) - 8.*Hayashi-Takagi A, Sawa A.:
"Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment."
Brain Res Bull.83 (3), 140-146. (2010) - 9.*Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A.:
"Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade."
Proc Natl Acad Sci U S A. 107 (12), 5622-5627. (2010) - 10.*Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A.:
"Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1."
Nat Neurosci. 13 (3), 327-332. (2010)
Recent Research Results
Related Links
- Laboratory for Multi-scale Biological Psychiatry | RIKEN Center for Brain Science
- Laboratory for Multi-scale Biological Psychiatry
Events
Lab Members
Principal investigator
- Akiko Hayashi-Takagi
- Team Leader
Contact Information
RIKEN CBS,
2-1 Hirosawa
Wako, Saitama
351-0198, Japan
Email: akiko.hayashi-takagi [at] riken.jp