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RIKEN Center for Sustainable Resource Science Advanced Organic Synthesis Research Team

Team Leader: Laurean Ilies (Ph.D.)

Research Summary

Laurean  Ilies(Ph.D.)

Our team aims at the development of “next generation synthesis” and its utilization for the creation of functional organic molecules. Our vision of “next generation synthesis” is inspired by the highly efficient reactions the Nature uses: direct and highly selective coupling of organic molecules without prefunctionalization with reactive groups. We envision that by precise design of ligands, efficient and selective catalysts enable the rapid assembly of complex functional molecules from simple building blocks. Also, we are particularly interested in the development of sustainable catalysis based on Earth-abundant metals such as manganese, iron, cobalt, copper, etc.

Main Research Fields

  • Chemistry

Related Research Fields

  • Complex Systems
  • Engineering

Keywords

  • Organic synthesis
  • Earth abundant metal catalysis
  • Functional materials
  • C-H bond activation

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Zhou, B., Sato, H., Ilies, L., and Nakamura, E.
    “Iron Catalyzed Remote Arylation of Aliphatic C-H Bond via 1,5-Hydrogen Shift”
    ACS Catal., 8, 8 (2018).
  • 2.*Ilies, L., Isomura, M.; Yamauchi, S., Nakamura, T., and Nakamura E.
    “Indole Synthesis via Cyclative Formation of 2,3-Dizincioindoles and Regioselective Electrophilic Trapping”
    J. Am. Chem. Soc. 139, 23 (2017).
  • 3.*Yoshida, T., Ilies, L., and Nakamura, E.
    “Iron-Catalyzed Borylation of Aryl Chlorides in the Presence of Potassium t-Butoxide”
    ACS Catal., 7, 3199 (2017).
  • 4.*Shang, R., Ilies, L., and Nakamura, E.
    “Iron-Catalyzed ortho C–H Functionalization of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand”
    J. Am. Chem. Soc., 138, 10132 (2016).
  • 5.*Shang, R., Ilies, L., Asako, S., and Nakamura, E.
    “Iron-Catalyzed C(sp2)–H Bond Functionalization with Organoboron Compounds”
    J. Am. Chem. Soc., 136, 14349 (2014).
  • 6.*Ilies, L., Matsubara, T., Ichikawa, S., Asako, S., Nakamura E.
    “Iron-Catalyzed Directed Alkylation of Aromatic and Olefinic Carboxamides with Primary and Secondary Alkyl Tosylates, Mesylates, and Halides”
    J. Am. Chem. Soc., 136, 13126 (2014)
  • 7.*Matsubara, T., Asako S., Ilies, L., and Nakamura, E.
    “Synthesis of Anthranilic Acid Derivatives through Iron-Catalyzed Ortho Amination of Aromatic Carboxamides with N-Chloroamines”
    J. Am. Chem. Soc., 136, 646 (2014).
  • 8.*Chen, Q., Ilies, L., and Nakamura, E.
    “Cobalt-Catalyzed ortho-Alkylation of Secondary Benzamide with Alkyl Chloride through Directed C–H Bond Activation”
    J. Am. Chem. Soc., 133, 428 (2011).

Related Links

Lab Members

Principal investigator

Laurean Ilies
Team Leader

Core members

Sobi Asako
Senior Scientist
Yuichiro Mutoh
Senior Scientist
Boobalan Ramadoss
Postdoctoral Researcher
Ikko Takahashi
Postdoctoral Researcher
Pinaki Bhusan De
Postdoctoral Researcher
Olena Kuleshova
Visiting Researcher

Careers

Position Deadline
Seeking a Postdoctoral Researcher or Research Scientist (W20094) Open until filled

Contact Information

Bioscience Building, 2F, room N211,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan

Email: laurean.ilies [at] riken.jp

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