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RIKEN Center for Sustainable Resource Science Drug Discovery Seed Compounds Exploratory Unit

Unit Leader: Minoru Yoshida (D.Agr.)

Research Summary

Minoru  Yoshida(D.Agr.)

The mission of the Seed Compounds Exploratory Unit is to contribute to searching for active compound candidates (hit compounds) for drug targets through high throughput screening (HTS) from compound libraries and, further, to identifying hit compounds (true hits) that truly act on the targets.

Main Research Fields

  • Chemistry

Related Research Fields

  • Biology

Keywords

  • Chemical Biology
  • Epigenetics
  • Mode of Action
  • Transcriptional Regulation
  • Chemical Screening for Drug Discovery

Selected Publications

  • 1. Takase, S., Hiroyama, T., Shirai, F., Maemoto, Y., Nakata, A., Arata, M., Matsuoka, S., Sonoda, T., Niwa, H., Sato, S., Umehara, T., Shirouzu, M., Nishigaya, Y., Sumiya, T., Hashimoto, N., Namie, R., Usui, M., Ohishi, T., Ohba, S., Kawada, M., Hayashi, Y., Harada, H., Yamaguchi, T., Shinkai, Y., Nakamura, Y., Yoshida, M., Ito, A.:
    "A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression."
    Nat. Commun., 14, 23 (2023)
  • 2. Revie, N.M., Iyer, K.R., Maxson, M.E., Zhang, J., Yan, S., Fernandes, C.M., Meyer ,K.J., Chen, X., Skulska, I., Fogal, M., Sanchez, H., Hossain, S., Li, S., Yashiroda, Y., Hirano, H., Yoshida, M., Osada, H., Boone, C., Shapiro, R.S., Andes, D.R., Wright, G.D., Nodwell, J.R., Poeta, M.D., Burke, M.D., Whitesell , L., Robbins ,N., Cowen, L.E.:
    "Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation."
    Nat. Commun., 13, 3634 (2022)
  • 3. Kato, H., Nemoto, K., Shimizu, M., Abe, A., Asai, S., Ishihama, N., Matsuoka, S., Daimon, T., Ojika, M., Kawakita, K., Onai, K., Shirasu, K., Yoshida, M., Ishiura, M., Takemoto. D., Takano, Y., Terauchi, R.:
    "Recognition of pathogen-derived sphingolipids in Arabidopsis."
    Science, 376, 857-860 (2022)
  • 4. Sasaki, K., Suzuki, M., Sonoda, T., Schneider-Poetsch, T., Ito, A., Takagi, M., Fujishiro, S., Sohtome, Y., Dodo, K., Umehara, T., Aburatani, H., Shin-ya, K., Nakao, Y., Sodeoka, M., Yoshida, M.:
    "Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells."
    Cell Chem. Biol., 29, 1153-1161.e5 (2022)
  • 5. Takayama, K., Honma, T., Suzuki, T., Kondoh, Y., Osada, H., Suzuki, Y., Yoshida, M., Inoue, S.:
    "Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth."
    Cancer Res., 81, 3495-3508 (2021)
  • 6. Jo, T., Nishikori, M., Kogure, Y., Arima, H., Sasaki, K., Sasaki, Y., Nakagawa, T., Iwai, F., Momose, S., Shiraishi, A., Kiyonari, H., Kagaya, N., Onuki, T., Shin-Ya, K., Yoshida, M., Kataoka, K., Ogawa, S., Iwai, K., Takaori-Kondo, A.:
    "LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells."
    Blood, 136, 684-697 (2020)
  • 7. Kobayashi, H., Hatakeyama, H., Nishimura, H., Yokota, M., Suzuki, S., Tomabechi, Y., Shirouzu, M., Osada, H., Mimaki, M., Goto, Y., Yoshida, M.:
    "Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations."
    Nat. Chem. Biol., 17, 335-343 (2020)
  • 8. Shirai, F., Mizutani, A., Yashiroda, Y., Tsumura, T., Kano, Y., Muramatsu, Y., Chikada, T., Yuki, H., Niwa, H., Sato, S., Washizuka, K., Koda, Y., Mazaki, Kyu Jang, M., Yoshida, H., Nagamori, A., Okue, M., Watanabe, T., Kitamura, K., Shitara, E., Honma, T., Umehara, T., Shirouzu, M., Fukami, T., Seimiya, H., Yoshida, M., Koyama, H.:
    "Design and Discovery of an Orally Efficacious Spiroindolinonebased Tankyrase Inhibitor for the Treatment of Colon Cancer."
    J Med Chem., 63, 4183-4204 (2020)
  • 9. Shirai, F., Tsumura, T., Yashiroda, Y., Yuki, H, Niwa H., Sato, S., Chikada, T., Koda, Y., Washizuka, K., Yoshimoto, N., Abe, M., Onuki, T., Mazaki, Y., Hirama, C., Fukami, T., Watanabe, H., Honma, T., Umehara, T., Shirouzu, M., Okue, M., Kano, Y., Watanabe, T., Kitamura, K., Shitara, E., Muramatsu, Y., Yoshida, H., Mizutani, A., Seimiya, H., Yoshida, M., Koyama, H.:
    "Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors."
    J Med Chem., 62, 3407-3427 (2019)
  • 10. Ito, S., Okuda, S., Abe, M., Fujimoto, M., Onuki, T., Nishimura,T., Takeichi, M.:
    "Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells."
    Nat. Commun., 8, 1834 (2017)

Related Links

Lab Members

Principal investigator

Minoru Yoshida
Unit Leader

Core members

Akiko Idei
Deputy Unit Leader
Ken Matsumoto
Senior Research Scientist
Seiji Matsuoka
Technical Scientist
Kousiki Mino
Senior Technical Staff
Shin-ya Okamoto
Senior Technical Staff
Satoko Maeda
Technical Staff I
Iku Kuwahara
Technical Staff I
Michiru Iwashita
Technical Staff I
Haruna Nishimura
Technical Staff I
Mari Agawa
Technical Staff I
Takeshi Sonoda
Technical Staff I
Yasue Ichikawa
Technical Staff I
Junko Mikuni
Technical Staff I
Mayumi Arata
Technical Staff I
Akiko Nakata
Technical Staff II
Taeko Wakana
Technical Staff II
Toshie Kaizuka
Technical Staff II
Ryotaro Yoshizumi
Junior Research Associate

Contact Information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: yoshidam [at] riken.jp

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