研究概要

主要論文

• 1. Noritsugu, K., Suzuki, T., Dodo, K., Ohgane, K., Ichikawa, Y., Koike, K., Morita, S., Umehara, T., Ogawa, K., Sodeoka, M., Dohmae, N., Yoshida, M., Ito, A.:
  "Lysine long-chain fatty acylation regulates the TEAD transcription factor."
  Cell Rep. 42(4), 112388 (2023)
• 2. Takase, S., Hiroyama, T., Shirai, F., Maemoto, Y., Nakata, A., Arata, M., Matsuoka, S., Sonoda, T., Niwa, H., Sato, S., Umehara, T., Shirouzu, M., Nishigaya, Y., Sumiya, T., Hashimoto, N., Namie, R., Usui, M., Ohishi, T., Ohba, S., Kawada, M., Hayashi, Y., Harada, H., Yamaguchi, T., Shinkai, Y., Nakamura, Y., Yoshida, M., Ito, A.:
  "A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression."
  Nat. Commun. 14, 23 (2023)
• 3. Sasaki, K., Suzuki, M., Sonoda, T., Schneider-Poetsch, T., Ito, A., Takagi, M., Fujishiro, S., Sohtome, Y., Dodo, K., Umehara, T., Aburatani, H., Shin-ya, K., Nakao, Y., Sodeoka, M., Yoshida, M.:
  "Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells."
  Cell Chem. Biol. 29(7), 1153-1161.e5. (2022)
• 4. Chhipi-Shrestha, J.K., Schneider-Poetsch, T., Suzuki, T., Mito, M., Khan, K., Dohmae, N., Iwasaki, S., Yoshida, M.:
  "Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns."
  Cell Chem. Biol. 29(2), 259-275 (2022)
• 5. Kato, H., Nemoto, K., Shimizu, M., Abe, A., Asai, S., Ishihama, N., Matsuoka, S., Daimon, T., Ojika, M., Kawakita, K., Onai, K., Shirasu, K., Yoshida, M., Ishiura, M., Takemoto. D., Takano, Y., Terauchi, R.:
  "Recognition of pathogen-derived sphingolipids in Arabidopsis."
  Science, 376, 857-860 (2022)
• 6. Yoshimoto, R., Chhipi-Shrestha, J.K., Schneider-Poetsch, T., Furuno, M., Burroughs, A.M., Noma, S., Suzuki, H., Hayashizaki, Y., Mayeda, A., Nakagawa, S., Kaida, D., Iwasaki, S., Yoshida, M.:
  "Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation."
  Cell Chem. Biol. 28(9), 1356-1365.e4. (2021)
• 7. Kobayashi, H., Hatakeyama, H., Nishimura, H., Yokota, M., Suzuki, S., Tomabechi, Y., Shirouzu, M., Osada, H., Mimaki, M., Goto, Y., Yoshida, M.:
  "Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations."
  Nat. Chem. Biol. 17(3), 335-343 (2021)
• 8. Shirai, F., Mizutani, A., Yashiroda, Y., Tsumura, T., Kano, Y., Muramatsu, Y., Chikada, T., Yuki, H., Niwa, H., Sato, S., Washizuka, K., Koda, Y., Mazaki, Kyu Jang, M., Yoshida, H., Nagamori, A., Okue, M., Watanabe, T., Kitamura, K., Shitara, E., Honma, T., Umehara, T., Shirouzu, M., Fukami, T., Seimiya, H., Yoshida, M., Koyama, H.:
  "Design and Discovery of an Orally Efficacious Spiroindolinonebased Tankyrase Inhibitor for the Treatment of Colon Cancer."
  J Med Chem., 63, 4183-4204 (2020)
• 9. Schneider-Poetsch, T., Yoshida, M.:
  "Along the central dogma-controlling gene expression with small molecules."
  Annu. Rev. Biochem. 87, 391-420 (2018)
• 10. Piotrowski, J.S., Li, S.C., Deshpande, R., Simpkins, S.W., Nelson, J., Yashiroda, Y., Barber, J.M., Safizadeh, H., Wilson, E., Okada, H., Gebre, A.A., Kubo, K., Torres, N., Leblanc, M.B., Andrusiak, K., Okamoto, R., Yoshimura, M., van Leeuwen, J., Shirahige, K., Baryshnikova, A., Brown, G., Saito, T., Costanzo, M., Andrews, B., Ohya, Y., Osada, H., Yoshida, M., Myers, C.L., Boone, C.:
  "Functional annotation of chemical libraries across diverse biological processes."
  Nat. Chem. Biol. 13(9), 982-993 (2017)

研究成果（プレスリリース）

• 

  2022年5月20日
  植物が病原菌特有の脂質を認識するしくみ

• 

  2020年11月10日
  機能低下したミトコンドリアを活性化させる化合物

• 

  2017年12月6日
  がん細胞の接着を回復させる機構

関連リンク

メンバーリスト

採用情報

募集職種	応募締切
テクニカルスタッフⅡ募集（W24281）	ポストが決まり次第
テクニカルスタッフⅠ募集（W24292）	ポストが決まり次第

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