1. Home
  2. Research
  3. Centers & Labs
  4. RIKEN Center for Integrative Medical Sciences

RIKEN Center for Integrative Medical Sciences Laboratory for Statistical and Translational Genetics

Team Leader: Chikashi Terao (M.D., Ph.D)

Research Summary

Chikashi  Terao(M.D., Ph.D)

Our laboratory is interested in how we can draw biologically useful information from DNA, RNA and genetic studies and how we can apply the information to clinical settings in order to understand the basics of diseases and traits, to improve management of diseases and to develop novel treatment. Various diseases and traits are our targets, especially autoimmune diseases, hematology diseases and malignancies. We integrate multi-layered information of genetics, intermediate phenotypes and clinical information together and analyze by cutting-edge statistical genetics, epidemiological methods and machine learning-based approach.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology
  • Human Genetics
  • Genetics/Chromosome dynamics
  • Epidemiology and preventive medicine

Keywords

  • genetics
  • translational research
  • Applied genetics
  • Statistical genetics
  • Machine-learning deep learning

Selected Publications

  • 1. Terao C*, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, Matsuda K, Murakami Y, McCarroll SA, Kubo M, Loh PR, Kamatani Y.:
    "Chromosomal alterations among age-related hematopoietic clones in Japan."
    Nature. 2020 Jun 24 DOI: 10.1038/s41586-020-2426-2
  • 2. Liu X, Takata S, Ashikawa K, Aoi T, Kosugi S, Terao C, Parrish NF, Matsuda K, Nakagawa H, Kamatani Y, Kubo M, Momozawa Y.:
    "Prevalence and Spectrum of Pathogenic Germline Variants in Japanese Patients With Early-Onset Colorectal, Breast, and Prostate Cancer."
    JCO Precision Oncology. 2020 :4, 183-191
  • 3. Nakabo S, Tsuji Y, Inagaki M, Tsuji H, Nakajima T, Murakami K, Terao C, Hashimoto M, Furu M, Tanaka M, Ito H, Fujii T, Mimori T, Fujii Y.:
    "Severe joint deformity and Patient Global Assessment of Disease are associated with discrepancies between sonographic and clinical remission: A cross-sectional study of rheumatoid arthritis patients."
    Mod Rheumatol. 2020 Apr 3:1-23.
  • 4. Sakai K, Tanikawa C, Hirasawa A, Chiyoda T, Yamagami W, Kataoka F, Susumu N, Terao C, Kamatani Y, Takahashi A, Momozawa Y, Hirata M, Kubo M, Fuse N, Takai-Igarashi T, Shimizu A, Fukushima A, Kadota A, Arisawa K, Ikezaki H, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Aoki D, Matsuda K.:
    "Identification of a novel uterine leiomyoma GWAS locus in a Japanese population."
    Sci Rep. 2020 Jan 27;10(1):1197. doi: 10.1038/s41598-020-58066-8.
  • 5. Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, Davidsson OB, Day FR, Sulem P, Jiang Y, Danielsson M, Davies H, Dennis J, Dunlop MG, Easton DF, Fisher VA, Zink F, Houlston RS, Ingelsson M, Kar S, Kerrison ND, Kinnersley B, Kristjansson RP, Law PJ, Li R, Loveday C, Mattisson J, McCarroll SA, Murakami Y, Murray A, Olszewski P, Rychlicka-Buniowska E, Scott RA, Thorsteinsdottir U, Tomlinson I, Moghadam BT, Turnbull C, Wareham NJ, Gudbjartsson DF; International Lung Cancer Consortium (INTEGRAL-ILCCO); Breast Cancer Association Consortium; Consortium of Investigators of Modifiers of BRCA1/2; Endometrial Cancer Association Consortium; Ovarian Cancer Association Consortium; Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium; Kidney Cancer GWAS Meta-Analysis Project; eQTLGen Consortium; Biobank-based Integrative Omics Study (BIOS) Consortium; 23andMe Research Team, Kamatani Y, Hoffmann ER, Jackson SP, Stefansson K, Auton A, Ong KK, Machiela MJ, Loh PR, Dumanski JP, Chanock SJ, Forsberg LA, Perry JRB.:
    "Genetic predisposition to mosaic Y chromosome loss in blood."
    Nature. 2019 Nov;575(7784):652-657.
  • 6. Howles SA, Wiberg A, Goldsworthy M, Bayliss AL, Gluck AK, Ng M, Grout E, Tanikawa C, Kamatani Y, Terao C, Takahashi A, Kubo M, Matsuda K, Thakker RV, Turney BW, Furniss D.:
    "Genetic variants of calcium and vitamin D metabolism in kidney stone disease."
    Nat Commun. 2019 Nov 15;10(1):5175.
  • 7. Terao C*, Momozawa Y, Ishigaki K, Kawakami E, Akiyama M, Loh PR, Genovese G, Sugishita H, Ohta T, Hirata M, Perry JRB, Matsuda K, Murakami Y, Kubo M, Kamatani Y.:
    "GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation."
    Nat Commun. 2019 Oct 17;10(1):4719. doi: 10.1038/s41467-019-12705-5.
  • 8. Terao C, Brynedal B, Chen Z, Jiang X, Westerlind H, Hansson M, Jakobsson PJ, Lundberg K, Skriner K, Serre G, Rönnelid J, Mathsson-Alm L, Brink M, Dahlqvist SR, Padyukov L, Gregersen PK, Barton A, Alfredsson L, Klareskog L, Raychaudhuri S.:
    "Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype."
    Am J Hum Genet. 2019 Sep 5;105(3):616-624.
  • 9. Ishikawa Y, Ikari K, Hashimoto M, Ohmura K, Tanaka M, Ito H, Taniguchi A, Yamanaka H, Mimori T, Terao C*.:
    "Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor."
    Ann Rheum Dis. 2019 Nov;78(11):1480-1487.
  • 10. Kosugi S, Momozawa Y, Liu X, Terao C, Kubo M, Kamatani Y.:
    "Comprehensive evaluation of structural variation detection algorithms for whole genome sequencing."
    Genome Biol. 2019 Jun 3;20(1):117. doi: 10.1186/s13059-019-1720-5.

Recent Research Results

Lab Members

Principal investigator

Chikashi Terao
Team Leader

Core members

Kohei Tomizuka
Senior Technical Scientist
Shunichi Kosugi
Research Scientist
Xiaoxi Liu
Research Scientist
Nao Tanaka
Junior Research Associate

Contact Information

3rd floor, East Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9553
Fax: +81-(0)45-503-9113
Email: chikashi.terao [at] riken.jp

Top