RIKEN Center for Biosystems Dynamics Research Laboratory for Advanced Biomolecular Engineering
Team Leader: Shunsuke Tagami (Ph.D.)
Research Summary
This team aims to engineer functional bio-macromolecules applicable to medical and basic biological researches, by integrating technologies in synthetic and structural biology including in vitro reconstruction of target protein complexes, in vitro evolution of protein/RNA, X-ray crystallography, and structure based protein engineering.
Keywords
- Protein evolution
- Protein structure
- Functional peptides
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Sumida T, Dubiley S, Wilcox B, Severinov K, Tagami S.:
"Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway"
ACS Chem. Biol., 14(7), 1619-1627 (2019) - 2.
*Tagami S, Attwater J, Holliger P.:
"Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function"
Nature Chemistry, 9, 325-332 (2017). - 3.
Tagami S, Sekine S, Minakhin L, Esyunina D, Akasaka R, Shirouzu M, Kulbachinskiy A, Severinov K, Yokoyama S.:
"Structural basis for promoter specificity switching of RNA polymerase by a phage factor"
Genes Dev, 28(5), 521-531 (2014) - 4.
Tagami S, Sekine S, Kumarevel T, Hino N, Murayama Y, Kamegamori S, Yamamoto M, Sakamoto K, Yokoyama S.:
"Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein."
Nature, 468(7326), 978-982 (2010)
Recent Research Results
Related Links
Lab Members
Principal investigator
- Shunsuke Tagami
- Team Leader
Core members
- Akira Wada
- Senior Research Scientist
- Almasul Alfi
- Research Scientist
- Peiying Li
- Research Scientist
- Kazumasa Ohtake
- Visiting Scientist
- Sota Yagi
- Visiting Scientist
- Aleksandr Popov
- Junior Research Associate
- Takuto Furuhashi
- Student Trainee
- Tami Kosuge
- Assistant
Contact Information
Room C516, Central Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9205