研究概要

主要論文

「*」は、理研外のみでの成果です。

• 1. Yagi S, Tagami S.:
  "An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins"
  Nature Communications 15, 5938 (2024).
• 2. Chaban A, Minakhin L, Goldobina E, Bae B, Hao Y, Borukhov S, Putzeys L, Boon M, Kabinger F, Lavigne R, Makarova KS, Koonin EV, Nair SK, Tagami S, Severinov K and Sokolova ML.:
  "Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail"
  Nature Communications 15, 317 (2024).
• 3. Mohri K, Huynh Nhat KP, Zouda M, Warashina S, Wada Y, Watanabe Y, Tagami S, Mukai H.:
  "Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin αvβ3 in tumor imaging"
  Eur. J. Pharm. Sci. 106339 (2022)
• 4. Alfi A, Popov A, Kumar A, Zhang KYJ, Dubiley S, Severinov K, Tagami S.:
  "Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2"
  ACS Synthetic Biology 11, 2022–2028 (2022)
• 5. Li P, Holliger P, Tagami S.:
  "Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion"
  Nature Communications 13, 3050 (2022)
• 6. Yagi S, Padhi AK, Vucinic J, Barbe S, Schiex T, Nakagawa R, Simoncini D, Zhang KYJ, Tagami S.:
  "Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase"
  J. Am. Chem. Soc. 143, 15998–16006 (2021)
• 7. Sumida T, Dubiley S, Wilcox B, Severinov K, Tagami S.:
  "Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway"
  ACS Chemical Biology, 14, 1619–1627 (2019)
• 8. *Tagami S, Attwater J, Holliger P.:
  "Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function"
  Nature Chemistry, 9, 325-332 (2017).
• 9. Tagami S, Sekine S, Minakhin L, Esyunina D, Akasaka R, Shirouzu M, Kulbachinskiy A, Severinov K, Yokoyama S.:
  "Structural basis for promoter specificity switching of RNA polymerase by a phage factor"
  Genes & Development 28, 521-531 (2014).
• 10. Tagami S, Sekine S, Kumarevel T, Hino N, Murayama Y, Kamegamori S, Yamamoto M, Sakamoto K, Yokoyama S.:
  "Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein."
  Nature 468, 978-982 (2010).

研究成果（プレスリリース）

• 

  2024年7月19日
  今は失われた古代のタンパク質構造を発見

• 

  2022年6月3日
  ペプチドとRNAの出会いが生命を生んだ？

• 

  2021年12月2日
  生命誕生初期のタンパク質を再現する試み

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