Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Ohyama, T., Takahashi, H., Sharma, H., Yamazaki, T., Gustincich, S., Ishii, Y., Carninci, P.:
  "An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs"
  Nucleic Acids Res. 48, 9346-9360 (2020)
• 2. Koga, R., Yamamoto, M., Kosugi, T., Kobayashi, N., Sugiki, T., Fujiwara, T., Koga, N.:
  "Robust folding of a de novo designed ideal protein even with most of the core mutated to valine"
  Proc. Nat. Acad. Sci. USA 117, 31149-31156 (2020)
• 3. Matsunaga, T., Matsuda, I., Yamazaki T., Ishii, Y.:
  "Decoherence optimized tilted-angle cross polarization: A novel concept for sensitivity-enhanced solid-state NMR using ultra-fast magic angle spinning"
  J. Magn. Reson. 322, 106857 (2021)
• 4. Xiao, Y., Matsuda, I., Inoue, M., Sasahara, T., Hoshi, M. and Ishii, Y.:
  "NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril."
  J. Biol. Chem. 295, 458-467 (2020).
• 5. Oouchi, M., Ukawa, J., Ishii, Y. & Maeda, H.:
  "Structural Analysis of the Terminal Groups in Commercial Hevea Natural Rubber by 2D-NMR with DOSY Filters and Multiple-WET Methods Using Ultrahigh-Field NMR."
  Biomacromolecules 20, 1394-1400, (2019).
• 6. Shi, X., Prasanna, C., Nagashima, T., Yamazaki, T., Pervushin, K., Nordenskiold, L.:
  "Structure and Dynamics in the Nucleosome Revealed by Solid-State NMR."
  Angew. Chem. Int. Ed. Engl. 57, 9734-9738.(2018)
• 7. *Yoo, B., Xiao, Y., McElheny, D., and Ishii, Y.:
  "E22G pathogenic mutation of β-amyloid (Aβ) enhances misfolding of Aβ40 by unexpected prion-like cross talk between Aβ42 and Aβ40."
  J. Am. Chem. Soc. 140, 2781–2784 (2018)
• 8. *Y. Xiao, B. Ma, D. McElheny, S. Parathasarathy, M. Hoshi, R. Nussinov, and Y. Ishii.:
  "Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer’s disease."
  Nat. Struct. Mol. Biol. 22, 499-505, (2015)
• 9. *Parthasarathy, S., Inoue, M., Xiao, Y., Matsumura, Y., Nabeshima, Y., Hoshi, M. and Ishii, Y.:
  "Structural Insight into an Alzheimer's Brain-Derived Spherical Assembly of Amyloid beta by Solid-State NMR"
  J. Am. Chem. Soc. 137, 6480-6483, (2015).
• 10. *Wickramasinghe, N.P., Parthasarathy, S., Jones, C.R., Bhardwaj, C., Long, F., Kotecha, M., Mehboob, S., Fung, L.W.M., Past, J., Samoson, A. & Ishii, Y.:
  "Nanomole-scale protein solid-state NMR by breaking intrinsic H-1 T-1 boundaries."
  Nature Methods 6, 215-218 (2009)

Related Links

Lab Members

Careers

Position	Deadline
Seeking a Postdoctoral Researcher or Research Associate (BDR-22-017)	Open until filled
Seeking a Senior Research Scientist, Research Scientist or Postdoctoral Researcher (BDR-22-016)	Open until filled

Contact Information