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RIKEN Center for Brain Science Brain Functional Dynamics Collaboration Laboratory

Team Leader: Masanori Matsuzaki (Ph.D.)

Research Summary

Masanori  Matsuzaki(Ph.D.)

We develop cognitive tasks for the common marmoset. We use fluorescent imaging methods to measure the dynamics of the neuronal activity in the marmoset cerebral cortex during the task performance. We also use optogenetics and chemogenetics to manipulate the neuronal activity during the task performance to reveal the causal relationship between the task-relevant activity and behaviors.

Main Research Fields

  • Biological Sciences

Related Research Fields

  • Informatics
  • Biological Sciences
  • Biology
  • Medicine, Dentistry & Pharmacy
  • Basic/Social brain science
  • Neurophysiology/General neuroscience

Keywords

  • Two-photon imaging
  • Marmoset
  • Prefrontal cortex
  • Neuron

Selected Publications

  • 1. Matsuzaki M., Ebina T.:
    "Common marmoset as a model primate for study of the motor control system."
    Current Opinion in Neurobiology 64, 103-110, 2020. doi: 10.1016/j.conb.2020.02.013.
  • 2. *Kato D., Wake H., Lee P.R., Tachibana Y., Ono R., Sugio S., Tsuji Y., Tanaka Y.H., Tanaka Y.R., Masamizu Y., Hira R., Moorehouse A.J., Tamamaki N., Ikenaka K., Matsukawa N., Fields R.D., Nabekura J., Matsuzaki M.:
    "Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity."
    Glia 68, 193-210, 2020. doi:10.1002/glia.23713.
  • 3. Ebina T., Obara K., Watakabe A., Masamizu Y., Terada S., Matoba R., Takaji M., Hatanaka A., Nambu A., Mizukami H., Yamamori T., Matsuzaki M.:
    "Arm movements induced by non-invasive optogenetic stimulation of the motor cortex in the common marmoset."
    Proc Natl Acad Sci USA 116, 22844-22850, 2019. doi:10.1073/pnas.1903445116.
  • 4. *Terada S., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.:
    "Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space."
    Nature Communications 9, 3550, 2018. doi: 10.1038/s41467-018-06058-8.
  • 5. *Tanaka Y.H., Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., Matsuzaki M.:
    "Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning."
    Neuron 100, 244-258, 2018. doi: 10.1016/j.neuron.2018.08.016.
  • 6. *Ebina T., Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S., Koketsu D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., Matsuzaki M.:
    "Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks."
    Nature Communications 9, 1879, 2018. doi: 10.1038/s41467-018-04286-6.
  • 7. *Kondo M., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.:
    "Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion."
    eLife 6, e26839, 2017. doi: 10.7554/eLife.26839.
  • 8. *Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., Yamamori T.:
    "Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates."
    Cell Reports 13, 1989-1999, 2015. doi: 10.1016/j.celrep.2015.10.050.
  • 9. *Hira R., Ohkubo F., Masamizu Y., Ohkura M., Nakai J., Okada T., Matsuzaki M.:
    "Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning."
    Nature Communications 5, 5551, 2014. doi: 10.1038/ncomms6551.
  • 10. *Masamizu Y., Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., Matsuzaki M.:
    "Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task."
    Nature Neuroscience 17, 987-994, 2014. doi: 10.1038/nn.3739.

Recent Research Results

Lab Members

Principal investigator

Masanori Matsuzaki
Team Leader

Careers

Position Deadline
Seeking a Research Scientist Position (W19201) Open until filled

Contact Information

CBS East Building
2-1 Hirosawa, Wako, Saitama,
351-0198, Japan
Tel: +81-(0)48-467-5274
Fax: +81-(0)48-467-6379
Email: masanori.matsuzaki [at] riken.jp

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