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RIKEN Center for Brain Science Neural Circuit of Multisensory Integration RIKEN Hakubi Research Team

RIKEN Hakubi Team Leader: Asuka Takeishi (Ph.D.)

Research Summary

Asuka  Takeishi(Ph.D.)

We are interested in how animals make behavioral decisions. Animals are exposed to continuously changing environmental stimuli, such as temperature, odor, light and sound. We sense and integrate these environmental cues in the nervous system in order to choose appropriate behavioral responses. We are currently investigating the mechanism of multi-sensory integration in the nervous system by analyzing behavior strategies and neural circuits of C. elegans that are exposed to multiple stimuli, especially temperature and odor. In addition to this biological approach, we incorporate mathematical and computational models to reveal the evolutionally-conserved fundamental mechanism of behavioral decision.

Main Research Fields

  • Biological Sciences

Related Research Fields

  • Biology
  • Neurophysiology/General neuroscience
  • Animal physiology/Animal behavior
  • Molecular biology


  • Neural Circuit
  • Behavioral analysis
  • Chemotaxis
  • Thermotaxis
  • In vivo calcium imaging

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Takeishi, A., Yu, Y.V., Hapiak, V.M., Bell, H.W., O’Leary, T. and Sengupta, P.:
    “Receptor-type guanylyl cyclases confer thermosensory responses in C. elegans
    Neuron 90, pp. 235-244. (2016).
  • 2.*Neal, S.J., Takeishi, A., O’Donnell, M.P., Park, J., Hong, M., Butcher, R.A., Kim, K. and Sengupta, P.:
    “Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling”
    eLife 10110. (2015)
  • 3.*Obata, F., Kuranaga, E., Tomioka, K., Ming, M., Takeishi, A., Chen, CH., Soga, T., and Miura, M.:
    “Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis”
    Cell Reports 7, pp. 821-833. (2014)
  • 4.*Takeishi, A., Kuranaga, E., Tonoki, A., Misaki, K., Yonemura, S., Kanuka, H. and Miura, M.:
    “Homeostatic epithelial renewal in the gut is required to dampen a fatal systemic wound response in Drosophila
    Cell Reports 3, pp. 919-930. (2013)

Related Links

Lab Members

Principal investigator

Asuka Takeishi
RIKEN Hakubi Team Leader

Core members

Zhenhua Shao
Postdoctoral Researcher
Masami Shima
Technical Staff I
Kazuko Yahagi
Research Part-time Worker I

Contact Information

2-1 Hirosawa, Wako-shi, Saitama
Email: asuka.takeishi [at] riken.jp