RIKEN Center for Sustainable Resource Science Cell Function Research Team

Team Leader: Keiko Sugimoto (Ph.D.)

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Research Summary

We investigate how plants integrate developmental and environmental cues to maximise organ growth under the changing environment. We also explore how plants establish and maintain cellular differentiation status and how various stress stimuli override the developmental commitments to undergo cellular reprogramming. These strategies should allow us identify key modulators of organ growth and reprogramming, thus providing molecular basis for crop improvement.

Main Research Fields

Biology

Related Research Fields

Agricultural Sciences

Keywords

Cell proliferation
Cell differentiation
Cell dedifferentiation
totipotency
regeneration

Selected Publications

1.Iwase A, Harashima H, Ikeuchi M, Rymen B, Ohnuma M, Komaki S, Morohashi K, Kurata T, Nakata M, Ohme-Takagi M, Grotewold E, Sugimoto K.:
"WIND1 promotes shoot regeneration through transcriptional activation of ESR1 in Arabidopsis"
Plant Cell 29(1): 54-69 (2017)
2.Rymen B, Kawamura A, Schäfer S, Breuer C, Iwase A, Shibata M, Ikeda M, Mitsuda N, Koncz C, Ohme-Takagi M, Matsui M, Sugimoto K.:
"ABA suppresses root hair growth via the OBP4 transcriptional regulator"
Plant Physiol 173(3): 1750-1762 (2017)
3.Ikeuchi M, Iwase A, Rymen B, H Harashima H, Shibata M, Ohnuma M, Breuer C, Morao AK, de Lucas M, De Veylder L, Goodrich J, Brady SM, Roudier F, and Sugimoto K.:
"PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis"
Nature Plants 15089 (2015)
4.Kumar N, Harashima H, Kalve S, Bramsiepe J, Wang K, Sizani BL, Bertrand LL, Johnson MC, Faulk C, Dale R, Simmons LA, Churchman ML, Sugimoto K, Kato N, Dasanayake M, Beemster G, Schnittger A, Larkin JC.:
"Functional conservation in the SIAMESE-RELATED family of Cyclin-dependent kinase inhibitors in land plants"
Plant Cell 27: 3065-3080 (2015)
5.Iwase A, Mita K, Nonaka S, Ikeuchi M, Koizuka K, Ohnuma M, Ezura H, Imamura J, Sugimoto K.:
"WIND1-based acquisition of regeneration competency in Arabidopsis and rapeseed"
J Plant Res 128(3):389-97 (2015)
6.Iwase A, Mitsuda N, Ikeuchi M, Ohnuma M, Koizuka C, Kawamoto K, Imamura J, Ezura H, Sugimoto K.:
"Arabidopsis WIND1 induces callus formation in rapeseed, tomato and tobacco"
Plant Signal & Behav 8(12): e27432 (2014)
7.Breuer C, Morohashi K, Kawamura A, Takahashi N. Ishida T, Umeda M, Grotewold E, and Sugimoto K.:
"Transcriptional repression of the APC/C activator CCS52A1 promotes the active termination of cell growth"
EMBO J 31, 4488-4801 (2012)
8.Iwase A, Mitsuda N, Koyama T, Hiratsu K, Kojima M, Arai T, Inoue Y, Seki M, Sakakibara H, Sugimoto K and Ohme-Takagi M.:
"The AP2/ERF transcription factor WIND1 controls cell dedifferentiation in Arabidopsis"
Curr Biol 21(6): 508-514 (2011)
9.Ishida, T., Adachi, S., Yoshimura, M., Shimizu, K., Umeda, M. and Sugimoto, K.:
"Auxin modulates the transition from the mitotic cycle to the endocycle in Arabidopsis"
Development 137: 63-71 (2010)
10.Breuer C, Kawamura A, Ichikawa T, Tominaga-Wada R, Wada T, Kondou Y, Muto Y, Matsui M, and Sugimoto K.:
"The trihelix transcription factor AtGTL1 controls ploidy-dependent cell growth in the Arabidopsis trichome"
Plant Cell 21: 2307-2322 (2009)