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RIKEN Center for Sustainable Resource Science Molecular Bioregulation Research Team

Team Leader: Shinya Hagihara (Ph.D.)

Research Summary

Shinya  Hagihara(Ph.D.)

Based on rational design or screening from chemical library, we discover novel molecules that regulate a variety of biological processes. We aim to utilize these molecules for understanding biological mechanism and contributing global issues.

Main Research Fields

  • Chemistry

Related Research Fields

  • Complex Systems
  • Biological Sciences
  • Biology
  • Agricultural Sciences


  • Organic Chemistry
  • Plant Science
  • Chemical Biology

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Yoshimura, M., Sato, A., Kuwata, K., Inukai, Y., Kinoshita, T., Itami, K., Tsuchiya, Y., and Hagihara, S.:
    "Discovery of shoot branching regulator targeting strigolactone re-ceptor DWARF14"
    ACS Central Science, 4, 230-234 (2018).
  • 2.*Uchida, N., Takahashi, K., Iwasaki, R., Yamada, R., Yoshimura, M., Endo, T. A., Kimura, S., Zhang, H., Nomoto, M., Tada, Y., Kinoshita, T., Itami, K., Hagihara, S., and Torii, K. U.
    "Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair"
    Nat. Chem. Biol.,14, 299-307 (2018).
  • 3.*Ziadi, A., Uchida, N., Kato, H., Hisamatsu, R., Sato, A., Hagihara, S., Itami K., and Torii, K. U.
    "Discovery of Synthetic Small Molecules that Enhance the Number of Stomata: C-H Functionalization Chemistry for Plant Biology"
    Chem. Commun., 53, 9632-9635 (2017).
  • 4.*Yamashita, S., Bergmann, D., Sato, A., Nomoto, M., Tada, Y., Humpf, H.-U., Itami, K., and Hagihara, S.
    "High-throughput Assay for Quantification of Aminoglycoside–Ribosome Interaction"
    Chem. Lett., 45, 1048-1050 (2016).
  • 5.*Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T., and Hagihara S.
    "Probing strigolactone receptors in Striga hermonthica with fluorescence"
    Science, 349, 864-868 (2015).
  • 6.*Hagihara, S., Lin, W.-C., Kusano, S., Chao, X.-G., Hori, T., Imoto, S., and Nagatsugi, F.
    "The Crosslink Formation of 2'-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-Mediated Silencing"
    Chembiochem,14, 1427-1429 (2013).
  • 7.*Hagihara, S., Tanaka, H., and Matile, S.
    "Boronic acid converters for reactive hydrazide amplifiers: polyphenol sensing in green tea with synthetic pores"
    J. Am. Chem. Soc.,130, 5656-5657 (2008).
  • 8.*Hagihara, S., Gremaud, L., Bollot, G., Mareda, J., and Matile, S.
    "Screening of pi-basic naphthalene and anthracene amplifiers for pi-acidic synthetic pore sensors"
    J. Am. Chem. Soc.,130, 4347-4351 (2008).
  • 9.Hagihara, S., Miyazaki, A., Matsuo, I., Tatami, A., Suzuki, T., and Ito, Y.
    "Fluorescently labeled inhibitor for profiling cytoplasmic peptide:N-glycanase"
    Glycobiology, 17, 1070-1076 (2007)
  • 10.*Nakatani, K., Hagihara, S., Goto, Y., Kobori, A., Hagihara, M., Hayashi, G., Kyo, M., Nomura, M., Mishima, M., and Kojima, C.
    "Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats"
    Nat. Chem. Biol., 1, 39-43 (2005).

Related Links

Lab Members

Principal investigator

Shinya Hagihara
Team Leader

Core members

Shuhei Kusano
Research Scientist
Kotaro Nishiyama
Postdoctoral Researcher

Contact Information

N401, Bioscience Building,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan

Email: hagi [at] riken.jp