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RIKEN Center for Sustainable Resource Science Molecular Bioregulation Research Team

Team Leader: Shinya Hagihara (Ph.D.)

Research Summary

Shinya  Hagihara(Ph.D.)

Based on rational design or screening from chemical library, we discover novel molecules that regulate a variety of biological processes. We aim to utilize these molecules for understanding biological mechanism and contributing global issues.

Main Research Fields

  • Chemistry

Related Research Fields

  • Complex Systems
  • Biological Sciences
  • Biology
  • Agricultural Sciences


  • Organic Chemistry
  • Plant Science
  • Chemical Biology

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Yoshimura, M., Sato, A., Kuwata, K., Inukai, Y., Kinoshita, T., Itami, K., Tsuchiya, Y., and Hagihara, S.:
    "Discovery of shoot branching regulator targeting strigolactone re-ceptor DWARF14"
    ACS Central Science, 4, 230-234 (2018).
  • 2.*Uchida, N., Takahashi, K., Iwasaki, R., Yamada, R., Yoshimura, M., Endo, T. A., Kimura, S., Zhang, H., Nomoto, M., Tada, Y., Kinoshita, T., Itami, K., Hagihara, S., and Torii, K. U.
    "Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair"
    Nat. Chem. Biol.,14, 299-307 (2018).
  • 3.*Ziadi, A., Uchida, N., Kato, H., Hisamatsu, R., Sato, A., Hagihara, S., Itami K., and Torii, K. U.
    "Discovery of Synthetic Small Molecules that Enhance the Number of Stomata: C-H Functionalization Chemistry for Plant Biology"
    Chem. Commun., 53, 9632-9635 (2017).
  • 4.*Yamashita, S., Bergmann, D., Sato, A., Nomoto, M., Tada, Y., Humpf, H.-U., Itami, K., and Hagihara, S.
    "High-throughput Assay for Quantification of Aminoglycoside–Ribosome Interaction"
    Chem. Lett., 45, 1048-1050 (2016).
  • 5.*Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T., and Hagihara S.
    "Probing strigolactone receptors in Striga hermonthica with fluorescence"
    Science, 349, 864-868 (2015).
  • 6.*Hagihara, S., Lin, W.-C., Kusano, S., Chao, X.-G., Hori, T., Imoto, S., and Nagatsugi, F.
    "The Crosslink Formation of 2'-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-Mediated Silencing"
    Chembiochem,14, 1427-1429 (2013).
  • 7.*Hagihara, S., Tanaka, H., and Matile, S.
    "Boronic acid converters for reactive hydrazide amplifiers: polyphenol sensing in green tea with synthetic pores"
    J. Am. Chem. Soc.,130, 5656-5657 (2008).
  • 8.*Hagihara, S., Gremaud, L., Bollot, G., Mareda, J., and Matile, S.
    "Screening of pi-basic naphthalene and anthracene amplifiers for pi-acidic synthetic pore sensors"
    J. Am. Chem. Soc.,130, 4347-4351 (2008).
  • 9.Hagihara, S., Miyazaki, A., Matsuo, I., Tatami, A., Suzuki, T., and Ito, Y.
    "Fluorescently labeled inhibitor for profiling cytoplasmic peptide:N-glycanase"
    Glycobiology, 17, 1070-1076 (2007)
  • 10.*Nakatani, K., Hagihara, S., Goto, Y., Kobori, A., Hagihara, M., Hayashi, G., Kyo, M., Nomura, M., Mishima, M., and Kojima, C.
    "Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats"
    Nat. Chem. Biol., 1, 39-43 (2005).

Recent Research Results

Related Links

Lab Members

Principal investigator

Shinya Hagihara
Team Leader

Core members

Masanori Izumi
Senior Scientist
Shuhei Kusano
Research Scientist
Sakuya Nakamura
Special Postdoctoral Researcher
Jekson Robertlee
Special Postdoctoral Researcher
Yuuma Shisaka
Special Postdoctoral Researcher
Michio Kuruma
Junior Research Associate

Contact Information

N401, Bioscience Building,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan

Email: hagi [at] riken.jp