Research Summary

Selected Publications

• 1.Endo R., Chen Y.K., Burke J., Takashima N., Suryawanshi N., Hui K.K.,Miyazaki T., Tanaka M.:
  "Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3."
  Proc. Natl. Acad. Sci. U. S. A., 120, e2211522120 (2023).
  doi: 10.1073/pnas.2211522120
• 2.Nakagawa Y., Shen C-h,, Komi Y., Sugiyama S., Kurinomaru T., Tomabechi Y., Krayukhina E., Okamoto K., Yokoyama T., Shirouzu M., Uchiyama S., Inaba M., Niwa T., Sako Y., Taguchi H., Tanaka M.:
  "Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system."
  Nat. Chem. Biol., 18, 321-331 (2022).
• 3.Shida T., Kamatari Y.O., Yoda T., Yamaguchi Y., Feig M., Ohhashi Y., Sugita Y., Kuwata K., and Tanaka M.:
  "Short disordered protein segment regulates cross-species transmission of a yeast prion."
  Nat. Chem. Biol., 16, 756-765 (2020) (cover).
• 4. Sugiyama, S., Tanaka, M.:
  "Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis."
  Proc Natl Acad Sci U. S. A., 116, 8909-8918 (2019).
• 5.Hui, K.K., Takashima, N., Watanabe, A., Chater, T.E., Matsukawa, H., Nekooki-Machida, Y., Nilsson, P., Endo, R., Goda, Y., Saido, T.C., Yoshikawa, T., Tanaka., M.:
  "GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA_A receptor trafficking and social behavior."
  Science Advances, 5(4), eaau8237 (2019).
• 6.Endo R., Takashima N., Nekooki-Machida Y., Komi Y., Hui K.K., Takao M., Akatsu H., Murayama S., Sawa A., and Tanaka M.:
  "TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD."
  Biol.Psychiatry, 84, 509-521 (2018).
• 7.Chen C.W., Tanaka M.:
  "Genome-Wide Translation Profiling by Ribosome-Bound tRNA Capture."
  Cell Rep., 23, 608-621 (2018).
• 8.Ohhashi Y., Yamaguchi Y., Kurahashi H., Kamatari Y.O., Sugiyama S., Uluca B., Piechatzek T., Komi Y., Shida T., Muller H., Hanashima S., Heise H., Kuwata K, and Tanaka M.:
  "Molecular basis for diversification of yeast prion strain conformation."
  Proc. Natl. Acad. Sci. U. S. A., 115, 2389-2394 (2018).
• 9.Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K.K., Kurosawa, M., Kim, S.H., Nukina, N.,Takimoto, E., Houslay, M.D., and Sawa, A.:
  "Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease."
  J. Clin. Invest., 127, 1438-1450 (2017).
• 10.Suzuki, G., Weissman, J.S., and Tanaka, M.:
  "[KIL-d] protein element confers antiviral activity via catastrophic viral mutagenesis."
  Mol. Cell, 60, 651-660 (2015).

Recent Research Results

• 

  Jun. 6, 2023
  Molecular over-reaction to ribosome stalling leads to cognitive disorders

• 

  Jul. 17, 2020
  A short segment of a prion protein plays a critical role in its susceptibility to cross-species prion transmission

• 

  Apr. 11, 2019
  Protein pileup affects social behaviors through altered brain signaling

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